1990
DOI: 10.1192/bjp.156.6.908
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Clomipramine for OCD

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“…An ex adiuvantibus confirmation of partial phenomenic overlap in OCD-related clinical manifestations is historically provided by clomipramine's effectiveness in treating such conditions, also leading researchers focusing on serotonergic mechanism [ 70 ]. The pharmacological finding that serotonergic agents are more effective for obsessions and compulsions rather than non-serotonergic antidepressants, and that their anti-obsessive benefit it is independent of the antidepressant action, also contributed to the separation of OCD from mood disorders [ 71 ].…”
Section: Treatment and Managementmentioning
confidence: 99%
“…An ex adiuvantibus confirmation of partial phenomenic overlap in OCD-related clinical manifestations is historically provided by clomipramine's effectiveness in treating such conditions, also leading researchers focusing on serotonergic mechanism [ 70 ]. The pharmacological finding that serotonergic agents are more effective for obsessions and compulsions rather than non-serotonergic antidepressants, and that their anti-obsessive benefit it is independent of the antidepressant action, also contributed to the separation of OCD from mood disorders [ 71 ].…”
Section: Treatment and Managementmentioning
confidence: 99%