Clonal chromosomal abnormalities in the Philadelphia chromosome negative cells of chronic myeloid leukemia patients treated with imatinib

Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: a case report

“…Tyrosine kinase inhibitors (TKIs) block the initiation of the BCR‐ABL1 pathway, and are currently used as a first‐line treatment for CML patients. However, it has been reported that after treatment with TKIs, Philadelphia chromosome negative (Ph‐negative) clones can emerge with various cytogenetic abnormalities associated with different outcomes . Most abnormalities are similar to those associated with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), including trisomy 8, monosomy 7 and 20q‐.…”

A 10-year median follow-up study after allogeneic stem cell transplantation for chronic myeloid leukemia in chronic phase from HLA-identical sibling donors

“…Osteonecrosis occurred in nine patients leading to a cumulative incidence of 12% (95% CI, [6][7][8][9][10][11][12][13][14][15][16][17][18] and was diagnosed at a median of 16 months after transplantation (range: 8-42 months). Half of them were surgically treated.…”

“…Resistance to imatinib has been reported as well as chromosomal abnormalities in Philadelphia chromosome-negative cells after imatinib treatment. 9 While there is no doubt that allogeneic SCT can cure CML in a substantial proportion of patients, there are surprisingly few studies on the long-term outcome after SCT in cured patients. Herein, we retrospectively report long-term results in our center after matched sibling SCT for CML in chronic phase and identified risk factors for outcome.…”

Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia

“…1 This phenomenon was first described in rare cases of patients treated with chemotherapy, 2,3 interferon-alpha (IFN), [4][5][6] and recently with imatinib. 1,[7][8][9][10][11][12][13][14][15][16][17][18][19] Although it has been suggested that this phenomenon may be associated with the development of myelodysplastic syndromes (MDSs), the criteria to diagnose MDS have not always been standard. Isolated instances of high-risk MDS or acute myeloid leukemia (AML) have been reported.…”