Clonal cytogenetic abnormalities in the plasma cell variant of Castleman disease

Reichard, Kaaren K.; Robinett, Sheldon; Foucar, M. Kathryn

doi:10.1016/j.cancergen.2011.04.003

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…Some studies have reported that lung lesions of PC-MCD other than mass were con rmed by pathological biopsy as interstitial brous thickening, plasma cell in ltration, and alveolar collapse. Reichard et al found karyotype change of chromosome 7p15 double-allele containing IL-6 locus in PC-CD, which may be related to the imbalance of IL-6 cytokines [27]. Mihara et al found that IL-6 could promote the migration of in ammatory cells and the production of antibodies by B cells [28].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

Cen¹,

Chen

Zeng

et al. 2021

Preprint

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BackgroundCastleman disease is clinically divided into unicentric Castleman disease (UCD), with hyaline-vascular Variant (HV) as major pathological pattern, and multicentric Castleman disease (MCD), with plasma cell type (PC) most commonly. Lung involvement is a serious complication of CD and usually leads to death.MethodWe retrospectively analyzed the medical records of 3 patients admitted to The First Affiliated Hospital of Guangxi Medical University during January 1, 2007 to September 30, 2020.Result2 male and 1 female with age ranging from 16 years old to 63 years old were admitted. The involved areas varied a lot. Respiratory symptoms were seen in 3 cases, along with fever, weight loss and splenomegaly. Dry and wet rales were found in all patients. All patients had hypoxemia and obstructive ventilation dysfunction. Computed tomography (CT) mainly showed bronchiectasis and mediastinal lymph node enlargement. All 3 cases were complicated with PNP. 1 case failed chemotherapy after local mass excision, 1 case remitted after chemotherapy but the lung lesion was irreversible, and 1 case was untreated and soon die of respiratory failure.ConclusionCases of HV-MCD with pulmonary affected were characterized by small airway lesions and poor prognosis. Respiratory symptoms along with systemic symptoms were common.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

Cen¹,

Chen

Zeng

et al. 2021

Preprint

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“…Overall, molecular aberrations were identified in 111 patients, which included seven cases with cytogenetic abnormalities and 104 cases with molecular data. The clinical characteristics and genetic abnormalities for each case are shown in Supplemental Table S1 and Supplemental Table S2 [7,[17][18][19][20][21][22][23][24][25][26][27][28]. The female-to-male ratio was 21:24 for iMCD and 40:14 for UCD cases; of note, the study from Chang et al [29] was composed entirely of female patients.…”

Section: Patient Cohortmentioning

confidence: 99%

A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease

Butzmann

Kumar

Sridhar

et al. 2021

Biology

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Castleman disease (CD) is a rare lymphoproliferative disorder known to represent at least four distinct clinicopathologic subtypes. Large advancements in our clinical and histopathologic description of these diverse diseases have been made, resulting in subtyping based on number of enlarged lymph nodes (unicentric versus multicentric), according to viral infection by human herpes virus 8 (HHV-8) and human immunodeficiency virus (HIV), and with relation to clonal plasma cells (POEMS). In recent years, significant molecular and genetic abnormalities associated with CD have been described. However, we continue to lack a foundational understanding of the biological mechanisms driving this disease process. Here, we review all cases of CD with molecular abnormalities described in the literature to date, and correlate cytogenetic, molecular, and genetic abnormalities with disease subtypes and phenotypes. Our review notes complex karyotypes in subsets of cases, specific mutations in PDGFRB N666S in 10% of unicentric CD (UCD) and NCOA4 L261F in 23% of idiopathic multicentric CD (iMCD) cases. Genes affecting chromatin organization and abnormalities in methylation are seen more commonly in iMCD while abnormalities within the mitogen-activated protein kinase (MAPK) and interleukin signaling pathways are more frequent in UCD. Interestingly, there is a paucity of genetic studies evaluating HHV-8 positive multicentric CD (HHV-8+ MCD) and POEMS-associated CD. Our comprehensive review of genetic and molecular abnormalities in CD identifies subtype-specific and novel pathways which may allow for more targeted treatment options and unique biologic therapies.

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“…Although clonal genetic alterations have been well documented in HVV, they have been only rarely demonstrated in PCV (39). The molecular alterations in PCV, especially in patients with MCD, have differed somewhat from those in HVV.…”

Section: Molecular Alterationsmentioning

confidence: 99%

Castleman Disease of the Thorax: Clinical, Radiologic, and Pathologic Correlation:From the Radiologic Pathology Archives

Kligerman¹,

Auerbach²,

Franks³

et al. 2016

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Castleman disease is a complex lymphoproliferative disease pathologically divided into two subtypes, the hyaline vascular variant (HVV) and the plasma cell variant (PCV). The HVV is the most common, is thought to represent a benign neoplasm of lymph node stromal cells, and is treated with surgical resection. It is most commonly found in the mediastinum, where it classically appears as a unicentric, avidly enhancing mass at computed tomography (CT) and magnetic resonance imaging. This appearance can mimic other avidly enhancing mediastinal masses, and location, clinical history, laboratory data, and nuclear medicine single photon emission CT (SPECT) and positron emission tomography (PET) studies can help narrow the differential diagnosis. Multicentric Castleman disease (MCD), which in the majority of cases is composed of the PCV, is an aggressive lymphoproliferative disorder associated with human herpesvirus infection, interleukin 6 dysregulation, and other systemic disorders. While it can be difficult to differentiate MCD from lymphoma, the presence of avidly enhancing lymph nodes can suggest the diagnosis. The purpose of this article is to review the clinical, immunologic, and pathologic findings associated with both unicentric Castleman disease and MCD and discuss how the imaging findings correlate with the pathophysiology of the disease.

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Clonal cytogenetic abnormalities in the plasma cell variant of Castleman disease

Cited by 16 publications

References 11 publications

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

WITHDRAWN: Lung Involvement Multicentric Castleman of Hyaline-vascular Variant: 3 cases

A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease

Castleman Disease of the Thorax: Clinical, Radiologic, and Pathologic Correlation:From the Radiologic Pathology Archives

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