Clonal evolution of B cells in transformation from low- to high-grade lymphoma

Matolcsy, András; Schattner, Elaine J.; Knowles, Daniel M.; Casali, Paolo

doi:10.1002/(sici)1521-4141(199904)29:04<1253::aid-immu1253>3.0.co;2-8

Cited by 79 publications

(23 citation statements)

References 55 publications

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“…Furthermore, we demonstrated that the amplicons of cutaneous and pulmonary tumors were of the same size by polymerase chain reaction method with primers for IGH gene rearrangement. In ours and others' studies with cloning and sequencing, amplicons of the same size from different lymphomas indicate the same clonal origin of these lymphomas [8,[17][18][19][20]. This case is unique in the exclusive pulmonary relapse and illustrates the importance of expert pathological review and incorporation of molecular study in the managements of lymphoma patients with unusual clinical features.…”

Section: Discussionsupporting

confidence: 56%

Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma

Chen

et al. 2009

Int J Hematol

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Primary cutaneous large B cell lymphoma, leg type (PCLBCL-leg) has recently been identified and recognized as a specific entity. Patients with PCLBCL-leg have a higher relapse rate and a poorer prognosis than the other types of primary cutaneous B cell lymphomas, and disease relapse is confined to the skin in the majority of cases with rare exclusive extracutaneous progression. The late occurrence of lymphoma in patients with a prior history of lymphoma may represent a relapse/progression or a distinct tumor unrelated to the original one. The distinction is of important clinical and therapeutic implications. Here, we report the case of a 90-year-old lady with a history of PCLBCL-leg in complete remission after radiotherapy that developed a huge, solitary pulmonary lymphoma without lymphadenopathy 14 months later. The latter was initially considered as stage IE primary pulmonary lymphoma and was treated with combination chemotherapy resulting in complete remission. Retrospective pathologic review and B cell clonality study revealed that the pulmonary tumor was a diffuse large B cell lymphoma of the same clonal origin as the PCLBCL-leg. This case is unique in the exclusive pulmonary relapse and illustrates the importance of expert pathological review and molecular study in the management of lymphoma patients with unusual clinical features.

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Section: Discussionsupporting

confidence: 56%

Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma

Chen

et al. 2009

Int J Hematol

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“…In these cases, immunostaining highlights the presence of malignant large B cells immersed in a sea of reactive T lymphocytes [88]. Approximately one to two thirds of patients with FL transform into large B-cell lymphoma during the course of their illness [38,104,105,168].…”

Section: Follicular Lymphomamentioning

confidence: 99%

Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis

Kremer

Quintanilla-Martı́nez

Nährig

et al. 2005

Virchows Arch

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Pathomorphological examination of trephine biopsies of the bone marrow (BM) represents a standard method for the diagnosis and staging of hematologic neoplasms and other disorders involving the BM. The increasing knowledge about the genetic basis and biology of hematologic neoplasms, as well as the recently proposed WHO classification system, provide the framework for an accurate diagnosis. Although conventional morphology remains the gold standard for paraffin-embedded BM trephines, immunohistochemical stainings have become an integral part of the diagnostic workup. Antibodies suitable for paraffin sections are generally applicable to BM trephines, but modifications of staining protocols may be necessary due to the alternative fixatives and decalcification procedures used for BM biopsies. The indications for immunostainings range from confirmation and classification of lymphoma involvement, subclassification of acute leukemias, and estimating blast counts in myelodysplastic and myeloproliferative syndromes to characterization of BM involvement in nonhematologic neoplasms. Although subtyping of NHL in the BM is more difficult from the point of morphology, classification of the entities that frequently involve the BM, especially the small B-cell lymphomas, can easily be achieved with the help of immunohistochemistry. In this review, we try to summarize the current state of the art in BM immunohistochemistry for the diagnosis of hematologic disorders. Moreover, diagnostic algorithms and useful antibody panels are proposed for a rational and cost-effective approach.

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“…The study of the IgR variable region genes is a key tool to provide circumstantial evidence for a role of an antigenic stimulus in clonal progression and selection of B cell lymphoproliferations [10][11][12][13][14]. Moreover, the deduced amino acid (aa) sequence of the combinatory region of the IgR, because of its homology to antibodies with defined specificity, may supply important information on its specificity.…”

Section: Introductionmentioning

confidence: 99%

Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas

Vita

Gasparotto

et al. 2002

Eur. J. Immunol.

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Clonal evolution of B cells in transformation from low- to high-grade lymphoma

Cited by 79 publications

References 55 publications

Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma

Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma

Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis

Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas

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