Clonidine Extended-Release Tablets for Pediatric Patients With Attention-Deficit/Hyperactivity Disorder

Jain, Rakesh K.; Segal, Scott; Kollins, Scott H.; Khayrallah, M.

doi:10.1016/j.jaac.2010.11.005

Cited by 121 publications

(108 citation statements)

References 33 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…In a previous trial, the efficacy of CLON-XR as monotherapy for treating ADHD in children and adolescents was demonstrated. 18 In this trial it also is suggested that CLON-XR used in combination with stimulants for the treatment of ADHD youth is well tolerated. The effect size for the CLON-XR plus stimulant group indicates an incremental benefit for combination treatment in children and adolescents whose symptoms are not ideally controlled with stimulants alone.…”

Section: Discussionmentioning

confidence: 95%

“…The efficacy of CLON-XR monotherapy in children and adolescents with ADHD has been demonstrated in Phase 3 clinical trial data. 18 An increasing rate of clonidine use in combination with psychostimulants for treating children and adolescents with ADHD has been documented in several studies, with a substantial proportion of stimulant-treated children also receiving clonidine. 19,20 Although clonidine is used in combination with stimulants in clinical practice, in few studies have the efficacy and safety of clonidine plus stimulant medication been systematically evaluated for the treatment of neuropsychological disorders.…”

mentioning

confidence: 99%

“…Two small studies (n ϭ 24 and n ϭ 67) 10,13 have been conducted in children with ADHD and comorbid aggression or conduct disorder, with mixed results. Given the high rate of treatment with a combination of clonidine plus stimulant in clinical settings, 19,20 the efficacy of the extendedrelease formulation of clonidine as a monotherapy, 18 and the need for treatment options for patients with ADHD, the current study was undertaken to assess the efficacy and safety of CLON-XR in combination with stimulants in youth with ADHD.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clonidine Extended-Release Tablets as Add-on Therapy to Psychostimulants in Children and Adolescents With ADHD

Kollins

Jain

Brams³

et al. 2011

Pediatrics

Self Cite

126

105

View full text Add to dashboard Cite

OBJECTIVE: To assess the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) combined with stimulants (ie, methylphenidate or amphetamine) for attention-deficit/hyperactivity disorder (ADHD). PATIENTS AND METHODS: In this phase 3, double-blind, placebo-controlled trial, children and adolescents with hyperactive- or combined-subtype ADHD who had an inadequate response to their stable stimulant regimen were randomized to receive CLON-XR or placebo in combination with their baseline stimulant medication. Predefined efficacy measures evaluated change from baseline to week 5. Safety was assessed by spontaneously reported adverse events, vital signs, electrocardiogram recordings, and clinical laboratory values. Improvement from baseline for all efficacy measures was evaluated using analysis of covariance. RESULTS: Of 198 patients randomized, 102 received CLON-XR plus stimulant and 96 received placebo plus stimulant. At week 5, greater improvement from baseline in ADHD Rating Scale IV (ADHD-RS-IV) total score (95% confidence interval: −7.83 to −1.13; P = .009), ADHD-RS-IV hyperactivity and inattention subscale scores (P = .014 and P = .017, respectively), Conners' Parent Rating Scale scores (P < .062), Clinical Global Impression of Severity (P = .021), Clinical Global Impression of Improvement (P = .006), and Parent Global Assessment (P = .001) was observed in the CLON-XR plus stimulant group versus the placebo plus stimulant group. Adverse events and changes in vital signs in the CLON-XR group were generally mild. CONCLUSIONS: The results of this study suggest that CLON-XR in combination with stimulants is useful in reducing ADHD in children and adolescents with partial response to stimulants.

show abstract

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Clonidine Extended-Release Tablets as Add-on Therapy to Psychostimulants in Children and Adolescents With ADHD

Kollins

Jain

Brams³

et al. 2011

Pediatrics

Self Cite

126

105

View full text Add to dashboard Cite

show abstract

“…Assessments indicate that Intuniv and Kapvay are approximately 40% to 75% as effective as the psychostimulants in managing the primary symptoms of ADHD. 45,46 However, these agents can be used along with a psychostimulant to provide better results if the patient has suboptimal response to the psychostimulant alone. 38,47,48 …”

Section: Alpha 2 -Agonistsmentioning

confidence: 99%

A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder

Briars

Todd

2016

The Journal of Pediatric Pharmacology and Therapeutics

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a common psychological diagnosis in children. This disorder impacts children and adolescents in all areas of life, including academic performance, extracurricular activities, and social interactions. ADHD can continue into adulthood where unemployment and substance abuse has been described. Although behavioral therapy is recommended for all patients with ADHD, medication management typically is initiated soon after diagnosis. Psychostimulants remain the primary medication of choice. This review focuses on the clinical use of psychostimulant medication in children and adolescents. The pharmacodynamic and pharmacokinetic differences between the newest long-acting formulations as well as commonly encountered adverse drug reactions, with suggested management strategies, will be highlighted. Non-stimulant therapy with atomoxetine or alpha 2 -adrenergic agonists is also reviewed. These agents may be warranted for patients who cannot tolerate psychostimulant therapy or have a comorbid condition. Finally, the 8-year multimodal treatment study results are also discussed.INDEX TERMS: adolescent, alpha 2 -agonist, amphetamine, atomoxetine, attention deficit disorder with hyperactivity, central nervous system stimulants, child, clonidine, methylphenidate, pediatric J Pediatr Pharmacol Ther 2016;21(3) :192-206

show abstract

“…59 There is good level of evidence provided by meta-analysis of efficacy for atomoxetine. 57,60,61 Extended-release clonidine [62][63][64] and extended-release guanfacine 65,66 are also efficacious options for the treatment of ADHD, alone or in combination with stimulants. Other pharmacologic alternatives evaluated for the treatment of ADHD are modafinil, bupropion, 57 and tricyclic antidepressants, 67 but all of them have showed weaker evidence of efficacy.…”

Section: Efficacy Of Interventionsmentioning

confidence: 99%

Developments and challenges in the diagnosis and treatment of ADHD

Dias

Kieling

Graeff-Martins

et al. 2013

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder, often associated with other psychiatric comorbidities, functional impairments, and poor long-term outcomes. The objective of this selected review is to describe current advances and challenges in the diagnosis and treatment of ADHD. The disorder is associated with neurobiological underpinnings and is highly heterogeneous in various aspects, such as symptom profiles, cognitive impairments, and neurobiological and genetic features. The efficacy and safety of short-term pharmacological treatments across the life cycle is well studied, but further research investigating long-term treatment, impact of treatment in preschoolers, and non-pharmacological interventions is needed. Future research is also needed to better characterize the neurodevelopmental pathways of the disorder, linking clinical and neurobiological information, less investigated populations, and new interventions.

show abstract

Clonidine Extended-Release Tablets for Pediatric Patients With Attention-Deficit/Hyperactivity Disorder

Cited by 121 publications

References 33 publications

Clonidine Extended-Release Tablets as Add-on Therapy to Psychostimulants in Children and Adolescents With ADHD

Clonidine Extended-Release Tablets as Add-on Therapy to Psychostimulants in Children and Adolescents With ADHD

A Review of Pharmacological Management of Attention-Deficit/Hyperactivity Disorder

Developments and challenges in the diagnosis and treatment of ADHD

Contact Info

Product

Resources

About