Clonidine provides opioid-sparing effect, stable hemodynamics, and renal integrity during laparoscopic cholecystectomy

Abstract

Clonidine enabled stable hemodynamics and prevented activation of RAAS seen as unchanged plasma renin activity. Clonidine may be beneficial during laparoscopy in patients with hypertension, cardiovascular, and/or renal diseases.

Systematic evaluation of different approaches for minimizing hemodynamic changes during pneumoperitoneum

“…Cardiac output was not changed in the clonidine group during CP, but decreased after release of CP [8]. Clonidine also was effective in reducing MAP and heart rate during laparoscopic cholecystectomy in the head-up position in another clinical trial, but no data were given regarding stroke volume or cardiac output [15]. Again, the possibility cannot be excluded that both esmolol as well as clonidine compromise physiologic reaction to compensate for hemodynamic changes of CP.…”

Circulatory and Respiratory Complications of Carbon Dioxide Insufflation

“…Some procedures were feasible at 5–7 mm Hg [25, 26], but the required abdominal distension varies with surgical procedure, anatomical conditions and myorelaxation. The recommendation is to apply the lowest possible pressure level for each particular case.…”

Effect of clonidine on the target dose of propofol: bispectral index evaluation

“…[14] Various drugs have been compared with clonidine as pre-anaesthetic medications, mainly benzodiazepines such as midazolam [7] and diazepam, which show greater post-operative agitation. [10][11][12] Gabapentin did not show superiority in post-operative pain relief. Ketamine showed better post-operative pain relief, but also had a greater incidence of agitation and hypersalivation, [21] and magnesium sulphate showed no benefits with respect to clonidine.…”

“…[9] Various studies have reported on the use of clonidine as a pre-anaesthetic medication and have shown its effects on hemodynamic stability, postoperative pain, hypnosis-sparing, and nausea and vomiting reduction. [10][11][12][13] This study aimed to analyse the effect of clonidine on the target dose of propofol in total intravenous anaesthesia.…”