Cloning, expression and antiviral bioactivity of Red-crowned Crane interferon-α

Tian, Li; Zhao, Panpan; Ma, Bo; Guo, Guangyang; Sun, Ying; Xing, Mingwei

doi:10.1016/j.gene.2014.04.036

Cited by 18 publications

(15 citation statements)

References 18 publications

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“…Interferons (IFNs) were first reported by Isaacs and Lindenmann as antiviral proteins that are generated by cells in response to viral infection [1,2]. IFNs are composed of three subgroups: type I, type II, and type III IFNs.…”

Section: Introductionmentioning

confidence: 99%

Interferon-omega: Current status in clinical applications

Zhao

Shao

et al. 2017

International Immunopharmacology

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Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many animals, but not canines and mice. It has been demonstrated to have antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human cancer cells and that it can be used to diagnose some diseases. While recombinant feline IFN-ω has been licensed in several countries for treating canine parvovirus, feline leukemia virus, and feline immunodeficiency virus infections, it also exhibits a certain efficacy when used to treat other viral infections or diseases. This review examines the known biological activity of IFN-ω and its clinical applications. We expect that the information provided in this review will stimulate further studies of IFN-ω as a therapeutic agent.

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Section: Introductionmentioning

confidence: 99%

Interferon-omega: Current status in clinical applications

Zhao

Shao

et al. 2017

International Immunopharmacology

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“…Interferons (IFNs) represent a large family of proteins that exhibit antiviral, cell growth regulatory, and immunomodulatory activities (Bonjardim, 2005;Tian et al, 2014). IFNs were initially described by Isaacs and Lindenmann (1987) as an antiviral protein synthesized by cells in response to viral infection.…”

Section: Introductionmentioning

confidence: 99%

Characterization and antivirus activities of a novel bovine IFN-omega24

Luo

Guo

Bao

et al. 2015

Molecular Immunology

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“…For determining the PEDV neutralizing activity of the serum antibodies we detected sample obtained from mice which were orally immunized with recombinant L. plantarum by antibody neutralization assay (microdetermination) as described before (Tian et al, 2014) with minor modifications. Under aseptic conditions serum and fecal samples were collected at 14, 35 and 42 days respectively after immunization, quantitative virus and serial diluted serum were added to Vero cells to evaluate serum neutralizing antibody titers, the neutralizing antibody titer PD50 (Median protective dose refers to the dose of serum or vaccine that protects half (50%) of the experimental animals) was determined by Karber's method at 72 h.…”

Section: Cell Neutralization Test (Fixed Virus Dilution Serum Method)mentioning

confidence: 99%

Construction and immunogenicity analysis of Lactobacillus plantarum expressing a porcine epidemic diarrhea virus S gene fused to a DC-targeting peptide

et al. 2018

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Porcine epidemic diarrhea virus (PEDV) is one of the most important causative pathogens of swine diarrhea, which is widely prevalent throughout the world and is responsible for significant economic losses in the commercial pig industry, both domestic and abroad. The spike (S) protein in the PEDV capsid structure can carry the major B lymphocyte epitope, which induces production of neutralizing antibodies and provides immunoprotective effects. Moreover, the conserved region encoded by the S gene can be considered a target for establishing a new diagnostic method and is a new candidate for vaccine design. In this study, use of anchorin pgsA' allowed the fusion protein of S-DCpep to express on the surface of recombinant Lactobacillus plantarum (NC8-pSIP409-pgsA'-S-DCpep) NC8 strain. Mice were immunized by lavage administration of the recombinant NC8-pSIP409-pgsA'-S-DCpep, which was observed to induce DC activation and high production of sIgA and IgG antibodies in experimental animals, while also eliciting production of significantly more IgAB220 B cells. More importantly, secretion of cytokines IFN-γ, IL-4 and IL-17 in mice that were vaccinated with NC8-pSIP409-pgsA'-S-DCpep was remarkably increased. The results of our study suggest that NC8-pSIP409-pgsA'-S-DCpep potently triggers cellular and humoral immune responses. The obtained experimental results can provide a theoretical basis that lays the foundation for production of a novel oral vaccine against PED.

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Cloning, expression and antiviral bioactivity of Red-crowned Crane interferon-α

Cited by 18 publications

References 18 publications

Interferon-omega: Current status in clinical applications

Interferon-omega: Current status in clinical applications

Characterization and antivirus activities of a novel bovine IFN-omega24

Construction and immunogenicity analysis of Lactobacillus plantarum expressing a porcine epidemic diarrhea virus S gene fused to a DC-targeting peptide

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