Cloning of Human Lymphocyte-Specific Interferon Regulatory Factor (hLSIRF/hIRF4) and Mapping of the Gene to 6p23–p25

Grossman, Alex; Mittrücker, Hans Willi; Nicholl, Jillian; Suzuki, Akira; Chung, Shinjae; Antonio, Laarni; Suggs, Sid; Sutherland, Grant R.; Siderovski, David P.; Mak, Tak W.

doi:10.1006/geno.1996.0547

Cited by 71 publications

(57 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During initial cloning and characterization of the hL-SIRF mRNA encoding the MUM1 transcription factor, mRNA expression was noted in a melanoma cell line and in normal melanocytes (8). Our data show that MUM1 is present in a subset of malignant melanomas.…”

Section: Figurementioning

confidence: 70%

Analysis of MUM1/IRF4 Protein Expression Using Tissue Microarrays and Immunohistochemistry

et al. 2001

View full text Add to dashboard Cite

The gene encoding MUM1 was characterized as a possible translocation partner in chromosomal abnormalities involving a significant number of multiple myelomas. The overexpression of the MUM1 protein as a result of translocation t(6;14) (p25;q32) identified MUM1 as a putative regulatory molecule involved in B-cell differentiation and tumorigenesis. The expression of MUM1 protein in multiple myelomas supports this hypothesis. In the current study, using tissue microarray technology, we have tested the expression of the MUM1 protein in 1335 human malignancies and normal tissues. Our data show that the MUM1 protein is expressed in a wide spectrum of hematolymphoid neoplasms and in malignant melanomas but is absent in other human tumors. In addition, in tissue microarrays as well as in conventional paraffin sections, MUM1 staining was found to lack specificity in detecting plasmacytic differentiation as compared with two markers, CD138/Syndecan and VS38, commonly used in paraffin immunohistochemistry for detection of plasma cells.

show abstract

Section: Figurementioning

confidence: 70%

Analysis of MUM1/IRF4 Protein Expression Using Tissue Microarrays and Immunohistochemistry

et al. 2001

View full text Add to dashboard Cite

show abstract

“…IRF4 codes for a transcription factor involved in the transcriptional regulation of interferon and interferon stimulated genes and is highly expressed in spleen and peripheral blood lymphocytes. 18 The gene FLJ11026, similar to rat rsec, is suggested to have a role in secretory vesicle function. MKPX, mitogen activated protein kinas phosphatase X, is a member of a family of kinase phosphatase genes, thought to play a role in the regulation of diverse cellular processes such as proliferation, differentiation and apoptosis through MAP kinases.…”

Section: Discussionmentioning

confidence: 99%

Cryptic subtelomeric 6p deletion in a girl with congenital malformations and severe language impairment

et al. 2003

View full text Add to dashboard Cite

Several cases with microscopically visible, terminal 6p deletions have been described, and a distinct clinical phenotype has emerged, including developmental delay, congenital heart malformations, ocular abnormalities, hearing loss and a characteristic facial appearance. We report a patient with a submicroscopic 6p deletion, detected by subtelomeric screening using fluorescence in situ hybridisation. This girl presented with typical facial dysmorphic features, hearing impairment, malformation of the anterior eye segment, an ASD and severe language impairment. However, her cognitive functions were within the normal range. Detailed FISH analysis with 20 BAC probes covering the distal 6p25 region estimated the size of the terminal deletion to 2.1 Mb, and thus this case narrows down the critical region for the 6p phenotype. The forkhead transcription factor gene FOXC1, involved in a spectrum of anterior eye chamber disorders, is deleted in this patient, together with several characterised and putative genes with yet unknown function.

show abstract

“…[2][3][4] Its expression is restricted to cells in lymphocytic and melanocytic lineages. [5][6][7] Furthermore, MUM1 expression was found to be highest in plasma cells among B lineage and in activated T cells among T lineage lymphocytes as determined by expression analysis of various hematopoietic cell lines. 1,[5][6][7] The physiological function of MUM1 is still unknown except that it works in cooperation with PU.1 as a transcriptional regulator in lymphCorrespondence: S Iida, Second Department of Internal Medicine, Nagoya City University Medical School, Kawasumi 1, Mizuho-chou, Mizuho-ku, Nagoya 467-8601, Japan; Fax: 81-52-852-0849 Received 1 October 1999; accepted 15 November 1999 oid cells.…”

Section: Introductionmentioning

confidence: 97%

“…1,[5][6][7] The physiological function of MUM1 is still unknown except that it works in cooperation with PU.1 as a transcriptional regulator in lymphCorrespondence: S Iida, Second Department of Internal Medicine, Nagoya City University Medical School, Kawasumi 1, Mizuho-chou, Mizuho-ku, Nagoya 467-8601, Japan; Fax: 81-52-852-0849 Received 1 October 1999; accepted 15 November 1999 oid cells. [6][7][8][9][10][11] It is of interest that absence of the MUM1 function in MUM1−/− mice results in extremely low levels of serum immunoglobulins and in marked reduction of both activated lymphocytes and plasma cells. These findings suggest prerequisite roles for MUM1 in lymphocyte activation and in terminal B cell differentiation.…”

Section: Introductionmentioning

confidence: 99%

MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies

et al. 2000

View full text Add to dashboard Cite

Cloning of Human Lymphocyte-Specific Interferon Regulatory Factor (hLSIRF/hIRF4) and Mapping of the Gene to 6p23–p25

Cited by 71 publications

References 2 publications

Analysis of MUM1/IRF4 Protein Expression Using Tissue Microarrays and Immunohistochemistry

Analysis of MUM1/IRF4 Protein Expression Using Tissue Microarrays and Immunohistochemistry

Cryptic subtelomeric 6p deletion in a girl with congenital malformations and severe language impairment

MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies

Contact Info

Product

Resources

About