Close Linkage Between Natriuretic Peptides and Obesity　― Impact of Sex on the Interorgan Metabolic Crosstalk ―

Nagoshi, Tomohisa

doi:10.1253/circj.cj-21-0202

Cited by 5 publications

(8 citation statements)

References 15 publications

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“…Second, we found that circulating NP levels were increased under HFD conditions, which was consistent with the previous ndings [37]. Various clinical studies have indicated that obese patients with or without heart failure show unexpectedly low NP levels [5,38,39]. The reason for the discrepancy between the clinical results and these experimental ndings remains to be determined.…”

Section: Discussionsupporting

confidence: 86%

“…In addition, our clinical study using the cardiac catheter database showed that an impaired cardiac function is associated with a decrease in body temperature, whereas plasma BNP elevation is associated with an increase in body temperature, suggesting the adaptive heat-retaining property of NP when the body temperature falls owing to unfavorable hemodynamic conditions [4]. Conversely, it has also been reported in both experimental [6,7] and clinical [10] studies that cold exposure induces the elevation of NP levels, which supports the idea that NPs induce the activation of the adipose tissue thermogenic program in response to cold stimuli as a compensatory mechanism [5,14]. A series of these studies indicated that NPs play a central role in "myocardial-adipose crosstalk".…”

Section: Introductionmentioning

confidence: 72%

“…A-type natriuretic peptide (ANP) as well as B-type natriuretic peptide (BNP), which are hormones produced in the heart, regulate blood pressure and uid homeostasis through vasodilatory and diuretic actions, and improve cardiac remodeling [1][2][3][4]. In addition to these classical actions of hemodynamic regulation on the renal and cardiovascular systems, growing evidence suggests that natriuretic peptides (NPs) also regulate the energy balance and glucose homeostasis as well as thermogenesis through interorgan metabolic crosstalk with adipose tissues, in which NP receptors (NPR-A) are expressed [4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.

Kimura

Nagoshi

et al. 2021

Preprint

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Background: Although natriuretic peptides (NPs) classically act on the renal and cardiovascular systems, increasing evidence suggests that NPs also largely coordinate inter-organ metabolic crosstalk with adipose tissues and play a critical role in energy metabolism. We recently reported that A-type NP (ANP) raises the intracellular temperature in cultured adipocytes in a low-temperature-sensitive manner. We herein investigated whether or not exogenous ANP treatment exerts a significant impact on adipose tissues in vivo using diet-induced obese mice.Methods and Results: C57BL/6 mice fed a high-fat diet (HFD) or normal-fat diet (NFD) for 13 weeks were treated with or without ANP infusion subcutaneously via osmotic pump for another 3 weeks (0.5 μg/kg/min). The intraperitoneal glucose tolerance test and insulin tolerance test showed that ANP treatment significantly ameliorated HFD-induced insulin resistance. Histological analyses revealed that HFD increased the brown adipose tissue (BAT) cell size with the accumulation of lipid droplets (whitening), which was suppressed by ANP treatment (re-browning). Furthermore, HFD induced enlarged lipid droplets in inguinal white adipose tissue (iWAT), crown-like structures in epididymal WAT (eWAT), and hepatic steatosis, all of which were substantially attenuated by ANP treatment. Likewise, ANP treatment markedly increased the expression of uncoupling protein-1 (UCP1), a specific marker of BAT, in iWAT (browning). ANP also further increased the UCP1 expression in BAT with an NFD. Accordingly, the cold tolerance test (at 4 °C for 4 h) demonstrated that the ANP-treated mice were tolerant to cold exposure.Conclusions: Exogenous ANP administration ameliorates HFD-induced insulin resistance by attenuating hepatic steatosis as well as by inducing adipose tissue browning (activation of the adipose tissue thermogenic program), leading to in vivo thermogenesis during cold exposure.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.

Kimura

Nagoshi

et al. 2021

Preprint

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“…In addition, our clinical study using the cardiac catheter database showed that a decrease in left ventricular ejection fraction is associated with a body temperature decrease, whereas high plasma BNP level is associated with a body temperature increase 4 . These data indicate that NPs have the adaptive heat-retaining property when body temperature falls owing to unfavorable hemodynamic conditions 4 , 5 , 9 . On the other hand, both experimental 6 , 7 and clinical 10 studies recently reported that cold exposure per se induces the elevations in ANP/BNP levels, which consistently supports the idea that NPs induce the activation of the adipose tissue thermogenic program in response to cold stimuli as a compensatory mechanism 5 , 14 .…”

Section: Introductionmentioning

confidence: 78%

“…These data indicate that NPs have the adaptive heat-retaining property when body temperature falls owing to unfavorable hemodynamic conditions 4 , 5 , 9 . On the other hand, both experimental 6 , 7 and clinical 10 studies recently reported that cold exposure per se induces the elevations in ANP/BNP levels, which consistently supports the idea that NPs induce the activation of the adipose tissue thermogenic program in response to cold stimuli as a compensatory mechanism 5 , 14 . A series of these studies indicated that NPs play a central role in “myocardial-adipose crosstalk”.…”

Section: Introductionmentioning

confidence: 78%

Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo

Kimura

Nagoshi

et al. 2021

Sci Rep

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Increasing evidence suggests natriuretic peptides (NPs) coordinate inter-organ metabolic crosstalk with adipose tissues and play a critical role in energy metabolism. We recently reported A-type NP (ANP) raises intracellular temperature in cultured adipocytes in a low-temperature-sensitive manner. We herein investigated whether exogenous ANP-treatment exerts a significant impact on adipose tissues in vivo. Mice fed a high-fat-diet (HFD) or normal-fat-diet (NFD) for 13 weeks were treated with or without ANP infusion subcutaneously for another 3 weeks. ANP-treatment significantly ameliorated HFD-induced insulin resistance. HFD increased brown adipose tissue (BAT) cell size with the accumulation of lipid droplets (whitening), which was suppressed by ANP-treatment (re-browning). Furthermore, HFD induced enlarged lipid droplets in inguinal white adipose tissue (iWAT), crown-like structures in epididymal WAT, and hepatic steatosis, all of which were substantially attenuated by ANP-treatment. Likewise, ANP-treatment markedly increased UCP1 expression, a specific marker of BAT, in iWAT (browning). ANP also further increased UCP1 expression in BAT with NFD. Accordingly, cold tolerance test demonstrated ANP-treated mice were tolerant to cold exposure. In summary, exogenous ANP administration ameliorates HFD-induced insulin resistance by attenuating hepatic steatosis and by inducing adipose tissue browning (activation of the adipose tissue thermogenic program), leading to in vivo thermogenesis during cold exposure.

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Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1

Nikolic,

Jeremic,

Lazarevic

et al. 2024

BioFactors

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In addition to their usual use in the treatment of cardiovascular disease, weak evidence is available for the potential of combined use of neprilysin inhibitor (sacubitril) and AT1 receptor antagonist (valsartan) to promote browning of white adipose tissue (WAT) in rats with metabolic syndrome (MetS). This study involved 32 male Wistar albino rats divided into four groups: CTRL—healthy control rats; ENT—healthy rats treated with sacubitril/valsartan; MS—rats with MetS; MS + ENT—rats with MetS treated with sacubitril/valsartan. After finishing the experimental protocol, different WAT depots were isolated for further analysis of molecular pathways. Molecular docking and molecular dynamics studies were used for in silico assessment of the binding affinity of sacubitril and valsartan towards subunits of mechanistic target of rapamycin complex 1 (mTORC1). Sacubitril/valsartan treatment markedly diminished morphological changes in adipose tissue, resulting in smaller lipid size and multilocular lipid droplet structure in WAT. We showed significantly higher protein expression of uncoupling protein‐1 (UCP‐1) and mTORC1 in WAT of MS + ENT rats, correlating with increased relative gene expression of browning‐related markers in tissue of rats treated with sacubitril/valsartan compared with MS group of rats. In silico analysis showed that sacubitrilat and valsartan exhibited the highest binding affinity against mTOR and mLST8, forming stable complexes with these mTORC1 subunits. The observed results confirmed strong potential of combined sacubitril/valsartan treatment to increase browning markers expression in different WAT depots in MetS condition and to form permanent complexes with mTOR and mLST8 subunits over the time.

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Close Linkage Between Natriuretic Peptides and Obesity　― Impact of Sex on the Interorgan Metabolic Crosstalk ―

Cited by 5 publications

References 15 publications

Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.

Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.

Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo

Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1

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Close Linkage Between Natriuretic Peptides and Obesity ― Impact of Sex on the Interorgan Metabolic Crosstalk ―

Cited by 5 publications

References 15 publications

Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.

Treatment With Atrial Natriuretic Peptide Induces Adipose Tissue Browning and Exerts Thermogenic Actions in Vivo.

Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo

Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1

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Product

Resources

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Close Linkage Between Natriuretic Peptides and Obesity　― Impact of Sex on the Interorgan Metabolic Crosstalk ―