Closed‐Loop Control of Macrophage Engineering Enabled by Focused‐Ultrasound Responsive Mechanoluminescence Nanoplatform for Precise Cancer Immunotherapy
Sixin Xu,
Lingkai Meng,
Qian Hu
et al.
Abstract:Macrophage engineering has emerged as a promising approach for modulating the anti‐tumor immune response in cancer therapy. However, the spatiotemporal control and real‐time feedback of macrophage regulatory process is still challenging, leading to off‐targeting effect and delayed efficacy monitoring therefore raising risk of immune overactivation and serious side effects. Herein, a focused ultrasound responsive immunomodulator‐loaded optical nanoplatform (FUSION) is designed to achieve spatiotemporal control … Show more
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