Clostridium difficile Infection

Paquette, Ian M.; Stewart, David B.

doi:10.1007/978-3-030-66049-9_52

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2024

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“…The hypervirulent ribotype 027 strain has two distinguishing virulence determinants: the deletion of the tcdC gene, which is a negative regulator for toxin production, and a higher frequency of resistance to fluoroquinolones. The expansion of hypervirulent strains might have been due to genetic adaptations and environmental factors favoring the transmission of the virulence of C. difficile, but which environmental factors trigger genetic expression is still under investigation [6,8].…”

Section: Introductionmentioning

confidence: 99%

Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile

Masset,

Gunaratnam,

Millette

et al. 2024

Antibiotics

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Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing research have identified many genes regulating diverse virulence factors for CDIs. These genes may be over- or under-expressed when triggered by various environmental and nutritional factors. The aims of this paper are to review the important genes involved in C. difficile pathogenesis and to identify modifiable environmental, nutritional, and other factors that may trigger the expression of these genes and thus offer new strategies to prevent CDIs.

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Section: Introductionmentioning

confidence: 99%