Clostridium perfringens bacteraemia, an analysis of 28 cases over 10 years in a university hospital of Madrid

López-Fabal, Fátima; Sanz, Núria; Ruiz-Bastián, Mario; Barros, Carlos; Gómez-Garcés, José Luís

doi:10.1016/j.eimce.2018.02.011

Cited by 7 publications

(20 citation statements)

References 13 publications

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“…Mortality rates for Clostridioides bacteremia reported in the literature were 15%–48% ( 17 – 19 , 28 – 31 ), which is lower than the mortality rates reported in our study. However, we focused on critically ill patients.…”

Section: Discussioncontrasting

confidence: 88%

“…Mortality rates for Clostridioides bacteremia reported in the literature were 15%-48% (17)(18)(19)(28)(29)(30)(31), which is lower than the mortality rates reported in our study. Indeed, Yang (31) and Fujita (17) revealed that patients who developed shock and required transfer to the ICU had worse outcomes than other patients.…”

Section: Discussioncontrasting

confidence: 85%

“…Data on Clostridioides bacteremia consist mainly of case reports ( 14 – 16 , 27 ) or case series that include a small number of patients ( 17 , 28 – 30 ). Larger publications focusing on anaerobic bacteremia do not provide details on patients’ characteristics and outcomes ( 2 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…Of note, Clostridioides bacteremia can present either as a single microbial bacteremia or as a polymicrobial bacteremia ( 2 , 28 , 30 , 31 ). Enterobacteriaceae were the most commonly associated bacteria, followed by Staphylococcus species.…”

Section: Discussionmentioning

confidence: 99%

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Non–C. difficileClostridioides Bacteremia in Intensive Care Patients, France

Morel¹,

Mulier²,

Ghrénassia³

et al. 2021

Emerg. Infect. Dis.

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In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.Medscape, LLC designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 75% minimum passing score and complete the evaluation at http://www.medscape.org/journal/eid; and (4) view/print certificate. For CME questions, see page XXX.

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Section: Discussioncontrasting

confidence: 88%

Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Non–C. difficileClostridioides Bacteremia in Intensive Care Patients, France

Morel¹,

Mulier²,

Ghrénassia³

et al. 2021

Emerg. Infect. Dis.

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“…Available literature confirms that C. perfringens , along with Clostridium difficile , is the cause of antibiotic-associated diarrhea (AAD), which is an important factor in morbidity and mortality, especially in hospitals, where up to 15% of AAD cases are caused by this bacterium [ 14 , 15 , 16 , 17 , 18 ]. Many risk factors for AAD have been described, including age, length of hospital stay, and the administration of broad-spectrum cephalosporins, broad-spectrum penicillin, and clindamycin [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Changes in Trabecular Bone, Cortical Bone and Hyaline Cartilage as Well as Disturbances in Bone Metabolism and Mineralization in an Animal Model of Secondary Osteoporosis in Clostridium perfringens Infection

Tomczyk-Warunek

Blicharski

Muszyński

et al. 2021

JCM

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There is no information regarding whether changes in the microbiological balance of the gastrointestinal tract as a result of an infection with Clostridium perfringens influence the development of metabolic bone disorders. The experiment was carried out on male broiler chickens divided into two groups: control (n = 10) and experimental (n = 10). The experimental animals were infected with Clostridium perfringens between 17 and 20 days of age. The animals were euthanized at 42 days of age. The structural parameters of the trabecular bone, cortical bone, and hyaline cartilage as well as the mineralization of the bone were determined. The metabolism of the skeletal system was assessed by determining the levels of bone turnover markers, hormones, and minerals in the blood serum. The results confirm that the disturbed composition of the gastrointestinal microflora has an impact on the mineralization and metabolism of bone tissue, leading to the structural changes in cortical bone, trabecular bone, and hyaline cartilage. On the basis of the obtained results, it can be concluded that changes in the microenvironment of the gastrointestinal tract by infection with C. perfringens may have an impact on the earlier development of osteoporosis.

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