Clostridium septicum Causing Sepsis With Severe Disseminated Intravascular Coagulation in a Patient With Crohn's Disease

Heibl, Christoph; Knoflach, P

doi:10.1038/ajg.2010.346

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…Like Clostridium perfringens , it can be found in the normal gut flora in humans [14]. After an incubation period of 5–48 hours, a possibly very painful swelling is accompanied by a rapidly spreading toxic-infectious clinical picture, ultimately leading to septic shock and multiple organ failure [1, 13, 15]. Next to several toxins and enzymes build by C. septicum , the toxin α causing hemolysis is mainly held responsible for the severity of the disease [16].…”

Section: Discussionmentioning

confidence: 99%

Foudroyant Course of an ExtensiveClostridium septicumGas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon

Hartel

Kutup

Gehl

et al. 2013

Case Reports in Orthopedics

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Background. Spontaneous gas gangrene is a rare disease in which Clostridium septicum frequently can be detected. After an incubation period of 5–48 hours, a very painful swelling is accompanied by a rapidly spreading toxic-infectious clinical picture ultimately leading to septic shock and multiple organ failure. We present a case of a completely documented rare infectious disease with triage findings including initial vital signs, initial medical findings, and the emergency lab., radiological, intraoperative, histopathological, microbiological, and postmortem results. After initial diagnosis of the underlying disease, the patient has been immediately transferred to the operating theatre. The laboratory findings reflect the devastating effect of toxin α which is a toxin typically produced by C. septicum. The patient presented both an anaemia and a manifest coagulopathy as well as an onset of multiple organ failure. Despite the aggressive medical and surgical measures that have been taken, this patient could not be saved. Discussion. The case presented vividly emphasises the difficulty to identify these cases early enough to save a patient. This documentation may help health care providers to identify this life threatening disease as early as possible in future cases.

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Section: Discussionmentioning

confidence: 99%

Foudroyant Course of an ExtensiveClostridium septicumGas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon

Hartel

Kutup

Gehl

et al. 2013

Case Reports in Orthopedics

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“…We used a total of 882 vetted species occurrence points (see (b) above). From the ecological niche models we obtained the mean value for each of the eight bioclimatic variables weighted by the cumulative probability of each value (weighted mean; W mean) to be used in comparative analyses, using the R package phyloclim ( Heibl, 2011 ). To infer the climatic history of Gunnera , we used the projection of our phylogenetic tree in environmental (each bioclimatic variable) and temporal space assuming Brownian motion evolution (BM; Evans et al, 2009 ; Schluter et al, 1997 ), using the R package phytools ( Revell, 2012 ).…”

Section: Methodsmentioning

confidence: 99%

Evolutionary persistence inGunneraand the contribution of southern plant groups to the tropical Andes biodiversity hotspot

Bacon

Velásquez-Puentes

Hinojosa

et al. 2018

PeerJ

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Several studies have demonstrated the contribution of northern immigrants to the flora of the tropical Andes—the world’s richest and most diverse biodiversity hotspot. However, much less is known about the biogeographic history and diversification of Andean groups with southern origins, although it has been suggested that northern and southern groups have contributed roughly equally to the high Andean (i.e., páramo) flora. Here we infer the evolutionary history of the southern hemisphere plant genus Gunnera, a lineage with a rich fossil history and an important ecological role as an early colonising species characteristic of wet, montane environments. Our results show striking contrasts in species diversification, where some species may have persisted for some 90 million years, and whereas others date to less than 2 Ma since origination. The outstanding longevity of the group is likely linked to a high degree of niche conservatism across its highly disjunct range, whereby Gunnera tracks damp and boggy soils in cool habitats. Colonisation of the northern Andes is related to Quaternary climate change, with subsequent rapid diversification appearing to be driven by their ability to take advantage of environmental opportunities. This study demonstrates the composite origin of a mega-diverse biota.

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“…Bakterie Clostridium septicum je popisována jako patogen, který obvykle vyvolává infekce ve spojitosti s nádorovým onemocněním gastrointestinálního traktu [4][5][6] a nespecifi ckým střevním zánětem [13,14]. Virulenci bakterie zvyšují toxiny, které vedou k nekróze tkání, diseminované intravaskulární koagulaci nebo hemolýze [13]. Jistou úlohu hraje i imunosupresivní léčba a cyklická neutropenie, vyšší riziko se uvádí u diabetiků [6,13].…”

Section: Diskuse a Závěrunclassified

“…Virulenci bakterie zvyšují toxiny, které vedou k nekróze tkání, diseminované intravaskulární koagulaci nebo hemolýze [13]. Jistou úlohu hraje i imunosupresivní léčba a cyklická neutropenie, vyšší riziko se uvádí u diabetiků [6,13]. V literatuře lze nalézt méně než 30 kasuistik pojednávajících o aortální disekci, kdy kauzálním patogenem byla C. septicum, obvykle u starších polymorbidních pacientů s kolorektálním karcinomem [15], nicméně byl zazname-…”

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Acute purulent pericarditis caused by Clostridium septicum

et al. 2018

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Akutní purulentní perikarditida je život ohrožující onemocnění s vysokou mortalitou. Incidence je nízká, přibližně 1 % všech případů perikarditidy. V západních zemích jsou nejčastějšími patogeny stafylokoky, streptokoky a pneumokoky, zatímco s mykobateriální etiologií se lze častěji setkat v rozvojových zemích. Popisujeme případ 71letého muže s cirhózou jater, u něhož došlo k rozvoji akutní purulentní perikarditidy. Toto onemocnění vyvolala grampozitivní bakterie druhu Clostridium septicum, která se běžně vyskytuje u infekcí asociovaných s nádory gastrointestinálního traktu. Přes dlouhodobou cílenou léčbu antibiotiky vedla infekce k rozvoji endokarditidy, která si vyžádala urgentní náhradu aortální chlopně.

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Clostridium septicum Causing Sepsis With Severe Disseminated Intravascular Coagulation in a Patient With Crohn's Disease

Cited by 7 publications

References 4 publications

Foudroyant Course of an ExtensiveClostridium septicumGas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon

Foudroyant Course of an ExtensiveClostridium septicumGas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon

Evolutionary persistence inGunneraand the contribution of southern plant groups to the tropical Andes biodiversity hotspot

Acute purulent pericarditis caused by Clostridium septicum

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