Clotting Tests and other Tests of the Haemostatic Mechanism in Cirrhosis of the Liver and their Diagnostic Significance

Abstract

Because of the important role played by the liver in the synthesis of the plasma proteins, investigations of changes in the plasma protein pattern are used in the diagnosis of liver dysfunction. Some of the blood coagulation factors are proteins with specific activities which can be relatively easily and rapidly analyzed. Quantitative analyses of blood coagulation factors have therefore been utilized as liver function tests. The following clotting factors are more or less decreased in parenchymatous diseases of the liver: factor I (fibrinogen), factor I1 (prothrombin), factor V (proaccelerin), factor VII (proconvertin), factor IX (Christmas factor) and factor X (Stuart factor) (1,2,3,5,6,7,8,9,12,13,14,16,18,19,21,22). Factor VII, or factor V I I complex (factor V I I + factor X), has been found by most recent authors to diminish earlier and to a greater degree than the other clotting factors (1,2,5,6,8,12,23,33). The thromboplastin generation test, reflecting the combined activity of factors V, VIII, IX, and X

Diagnosis and Assessment of Bleeding Tendency in Chronic Liver Failure Using Three Simple Coagulation Tests

“…In the present study the prothrombin time (PT), which is sensitive to variations of the levels of fibrinogen, prothrombin, factors V, VII and X, showed good correlation with the serum albumen concentration, though it was also found to be normal in 37 % of the non-bleeders and two of the patients who bled. An abnormal -Bengtsen (1962) and agrees with the results of Coccheri (personal communication) and Owren (1969) with Normotest (which is a standardized, commercial version of the PaP test). The superiority of the PaP in the present work is presumably related to its special sensitivity within the range of concentrations of the three relevant clotting factors found in patients with chronic liver disease.…”

Coagulation Profile in Liver Diseases: A Study of 300 Cases in a Tertiary Care Hospital in Uttarakhand, India

“…In the present study, BT is prolonged in 34% (102/300) patients, which agrees with the study of Hedenberg and Korsan-Bengtsen. 9 The CT can remain normal even in the presence of severe individual factor deficiency. 10 In the present study, abnormal prolongation of CT was observed in only 32 (10.6%) out of 300 patients.…”

Coagulation profile in liver diseases: A study of 250 cases in a tertiary care hospital

“…Present study ~ 188 ~ Hedenberg and Korsan-Bengtsen [12] 19 1967 Spector and Corn [9] 47.5 2005 Arif et al [14] 77.5 2014 Shah and Jansari [2] 62 2016 Bhatia et al [1] 39.3 2020…”