Cloud point, fluorimetric and 1H NMR studies of ibuprofen-polymer systems

Khan, Iqrar Ahmad; Anjum, Kahkashan; Pulikkal, Ajmal Koya; Qadeer, Atiytul; Kabir-ud-Din, †

doi:10.1016/j.molstruc.2013.10.043

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…Influence of six polymers viz. HEC, HPMC, PEG, PVP, NaCMC and DxS on solution properties of the amphiphilic drug IBF has been reported by Khan et al [15]. Amongst the polymers used by them, only HPMC showed clouding behavior.…”

Section: Polymer-amphiphile Interactionsmentioning

confidence: 80%

“…The PEO-PPO-PEO triblock polymers interact with the ionic surfactants [7][8][9][10][11]. Hydroxypropyl methyl cellulose (HPMC) is a pharmaceutically important polymer (2) containing both the hydrophobic and hydrophilic structural units [12][13][14][15]. In formulations, it either serves as a part of regulating system, as a neutral substance to provide adequate flow properties, or as an adsorbent for the drug.…”

Section: Polymersmentioning

confidence: 99%

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Polymer-Amphiphile Interactions: An Overview

Panda

Kamil

2017

Eurasian Chem. Tech. J.

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Interactions between the polymers and amphiphiles in aqueous solutions have generated considerable interest among researchers because of the widespread applications, relatively complex behavior and improved physicochemical properties of the mixtures. Numerous studies on the surfactant-polymer systems have been carried out in recent years and the number of scientific reports has considerably increased. Various applications of polymers in different areas and many works concerning the amphiphiles are being published every year. Usually, the mixed systems containing polymers and amphiphiles show solution properties different from those of individual solutions due to interaction between the components. The present review article mainly focuses on the behaviour of polymers in aqueous solutions, in the absence or presence of amphiphiles, such as surfactants, drugs, etc. It also summarizes effect of the nature of amphiphiles on aggregation properties of polymers in aqueous solution, and interaction of conventional as well as gemini surfactants with polymers.

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Section: Polymer-amphiphile Interactionsmentioning

confidence: 80%

Section: Polymersmentioning

confidence: 99%

Polymer-Amphiphile Interactions: An Overview

Panda

Kamil

2017

Eurasian Chem. Tech. J.

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“…The chemical shifts are denoted in Table S2 , and the detailed chemical shift spectrum is represented in Figure S1 . The 1 H NMR spectra of pure IBU displayed peaks at 0.86 (6H, 2CH 3 ), 1.34 (3H, CH 3 ), 1.81 (1H, CH), 2.41 (2H, CH 2 ), 3.63 (1H, CH), 7.11 and 7.19 (4H, aromatic), and 12.24 ppm (1H, COOH) were observed [ 51 ]. The chemical shifts were observed in all the formulations, although the carboxylic acid proton peak at 12.24 ppm was not detected in all the formulations (IBU–HPβ-CD, IBU-PVP VA-64, and TIC), which might be due to the hydrogen bond formation with both HPβ-CD and PVP VA-64.…”

Section: Resultsmentioning

confidence: 99%

Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug Solubility via Hot-Melt Extrusion: A Quality by Design Approach

Munnangi,

Youssef,

Narala

et al. 2023

Pharmaceutics

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Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes to improve the solubility and dissolution of ibuprofen (IBU). Molecular docking confirmed IBU’s hosting in Hydroxypropyl-β-cyclodextrin (HPβ-CD), while phase solubility revealed its complex stoichiometry and stability. In addition, an 11 mm twin-screw co-rotating extruder with PVP VA-64 as an auxiliary substance aided the complex formation and extrusion. Using QbD and the Box–Behnken design, we studied variables (barrel temperature, screw speed, and polymer concentration) and their impact on solubility and dissolution. The high polymer concentration and high screw speeds positively affected the dependent variables. However, higher temperatures had a negative effect. The lowest barrel temperature set near the Tg of the polymer, when combined with high polymer concentrations, resulted in high torques in HME and halted the extrusion process. Therefore, the temperature and polymer concentration should be selected to provide sufficient melt viscosities to aid the complex formation and extrusion process. Studies such as DSC and XRD revealed the amorphous conversion of IBU, while the inclusion complex formation was demonstrated by ATR and NMR studies. The dissolution of ternary inclusion complexes (TIC) produced from HME was found to be ≥85% released within 30 min. This finding implied the high solubility of IBU, according to the US FDA 2018 guidance for highly soluble compounds containing immediate-release solid oral dosage forms. Overall, the studies revealed the effect of various process parameters on the formation of CD inclusion complexes via HME.

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“…This observation suggests that in the aggregate phase formed by these ILs, the APIs (SA, Par, and Ibu) should interact on the aggregate surface, as already reported in the literature for other IL + API systems. , The Δδ (δ bonded – δ free ) represents the variation in the chemical shifts of the analyzed nuclei. The APIs signals were attributed according to refs. − …”

Section: Resultsmentioning

confidence: 99%

Heteroassembly Ability of Dicationic Ionic Liquids and Neutral Active Pharmaceutical Ingredients

et al. 2018

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Extensive investigation of interactions and aggregation properties of IL + API systems is necessary to apply ionic liquids (ILs) with different hydrophobic characteristics to drug delivery or in active pharmaceutical ingredient (API) formulations. Therefore, this study aims to investigate the heteroassembly between dicationic ILs ([BisOct(MIM) 2 ][2X], in which X is Br or BF 4 , and [BisOct(BnIM) 2 ][2Br]), both in the absence and the presence of neutral APIs (salicylic acid, ibuprofen, and paracetamol) with different functional groups. Isothermal titration calorimetry results demonstrate that IL–API associations occur at very low concentrations of IL. These results were reinforced by electrospray ionization mass spectrometry with variable collision-induced dissociation, in which the IL dication interactions with APIs were detected. The strength of the dication–API interaction was determined from E cm,1/2 data. The aggregation parameters (cac, Δ G agg ° , and K ) between ILs and APIs were evaluated by conductivity. The 1 H NMR data showed that differences in chemical shifts provided relevant insights about interaction sites in both components.

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Cloud point, fluorimetric and 1H NMR studies of ibuprofen-polymer systems

Cited by 12 publications

References 29 publications

Polymer-Amphiphile Interactions: An Overview

Polymer-Amphiphile Interactions: An Overview

Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug Solubility via Hot-Melt Extrusion: A Quality by Design Approach

Heteroassembly Ability of Dicationic Ionic Liquids and Neutral Active Pharmaceutical Ingredients

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