Clozapine Response and Adverse Effects in Nine Brain-Injured Patients

Michals, Marcia L.; Crismon, M. Lynn; Roberts, Shannon L.; Childs, Allen

doi:10.1097/00004714-199306000-00008

Cited by 71 publications

(20 citation statements)

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“…The observation of Michals et al (1993) suggests that this risk may be increased among patients with TBI, although the very small number of patients described in that report makes this cautionary note preliminary at best. The effect of clozapine on post-traumatic cognitive impairments in this population is also not clear from these reports, but its substantial anticholinergic properties are worrisome in this regard.…”

Section: Treatment Of Post-traumatic Psychosismentioning

confidence: 80%

“…However, there is at present a dearth of reports with which to guide selection of atypical antipsychotic agents in this population. Michals et al (1993) used clozapine to treat nine brain-injured patients with psychotic symptoms or outbursts of rage and aggression that had failed to respond to other medications. Three of these patients demonstrated marked improvements in aggression and/or psychosis, three demonstrated decreased agitation and auditory hallucinations, and an adequate duration of treatment was not achieved in three patients.…”

Section: Treatment Of Post-traumatic Psychosismentioning

confidence: 99%

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Psychosis following traumatic brain injury

Arciniegas

Harris

Brousseau

2003

International Review of Psychiatry

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Psychosis is a relatively infrequent but potentially serious and debilitating consequence of traumatic brain injury (TBI), and one about which there is considerable scientific uncertainty and disagreement. There are several substantial clinical, epidemiological, and neurobiological differences between the post-traumatic psychoses and the primary psychotic disorders. The recognition of these differences may facilitate identification and treatment of patients whose psychosis is most appropriately regarded as post-traumatic. In the service of assisting psychiatrists and other mental health clinicians in the diagnosis and treatment of persons with post-traumatic psychoses, this article will review post-traumatic psychosis, including definitions relevant to describing the clinical syndrome, as well as epidemiologic, neurobiological, and neurogenetic factors attendant to it. An approach to evaluation and treatment will then be offered, emphasizing identification of the syndrome of post-traumatic psychosis, consideration of the differential diagnosis of this condition, and careful selection and administration of treatment interventions.

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Section: Treatment Of Post-traumatic Psychosismentioning

confidence: 80%

Section: Treatment Of Post-traumatic Psychosismentioning

confidence: 99%

Psychosis following traumatic brain injury

Arciniegas

Harris

Brousseau

2003

International Review of Psychiatry

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“…Clozapine is not frequently used because of its unfavorable side effect profile. One series found it effectively controlled agitation in three of nine patients, but resulted in seizures in two patients [121]. Quetiapine was found to reduce irritability and aggression in seven subjects in a 6-week open-label, flexible-dose study [122].…”

Section: Lithiummentioning

confidence: 99%

Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review

Chew

Zafonte²

2009

JRRD

163

103

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Abstract-Pharmacological management of neurobehavioral disorders following traumatic brain injury (TBI) is common practice. However, the evidence available to guide this practice remains sparse. This review summarizes, in brief, the state of knowledge, organized via a time continuum from injury as well as by symptom complex. The areas of neuroprotection, hypoarousal, attention and memory deficits, aggression, agitation, depression, and mania are reviewed. The literature was searched with PubMed on the terms "traumatic brain injury" or "brain injury" with "pharmacology" (and the symptoms according to which this review is arranged). Additional searches were conducted with the specific symptoms as search terms, crossed with the therapeutic agents or drug classes discussed. Where a paucity of prospective data exists, case reports and retrospective studies are included. Studies to date have yielded minimal positive evidence for enhancing function, memory, and behavior after TBI. No single agent likely will become sentinel in the recovery process, and combination therapy in the acute and postacute settings are required. A need exists to further define the role of psychopharmacology in postacute TBI medicine and the specific characteristics of subpopulations who might benefit.

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“…Well succeeded treatments using risperidone (Schreiber et al 1998) and olanzapine (Arciniegas et al 2003;Warden et al 2006) were reported, as well as the association between risperidone with galantamine (Bennouna et al 2005). The use of clozapine was also described (Michals et al 1993), but the side effects' profi le can be adverse.…”

Section: Treatmentmentioning

confidence: 99%

Psychiatric disorders and traumatic brain injury

Schwarzbold¹,

Diaz²,

Martins

et al. 2008

NDT

101

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Psychiatric disorders after traumatic brain injury (TBI) are frequent. Researches in this area are important for the patients' care and they may provide hints for the comprehension of primary psychiatric disorders. Here we approach epidemiology, diagnosis, associated factors and treatment of the main psychiatric disorders after TBI. Finally, the present situation of the knowledge in this fi eld is discussed.

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Clozapine Response and Adverse Effects in Nine Brain-Injured Patients

Cited by 71 publications

References 0 publications

Psychosis following traumatic brain injury

Psychosis following traumatic brain injury

Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review

Psychiatric disorders and traumatic brain injury

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