Clubbing

Gibb, Charlotte; Smith, Philip J.; Miller, R F

doi:10.12968/hmed.2013.74.sup11.c170

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…A Lovibond or profile angle between the skin proximal to the cuticle and proximal takeoff of the nail exceeding 180°, a hyponychial angle between the skin proximal to the cuticle and distal nail exceeding 192°, and a phalangeal depth ratio (between the DPD and IPD) greater than 1 are all considered diagnostic of clubbing (30). The Schamroth sign (or Schamroth window test) is defined as the loss of the diamond-shaped window between two juxtaposed nailbeds (31). Additionally, the digital index is computed by first measuring the perimeter of each finger at the DIP joint and at the nail bed and then adding the 10 nail bed-to-distal interphalangeal ratios.…”

Section: Clinical Presentation Of Hoamentioning

confidence: 99%

Hypertrophic Osteoarthropathy: Clinical and Imaging Features

Yap¹,

Skalski²,

Patel³

et al. 2017

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Hypertrophic osteoarthropathy (HOA) is a medical condition characterized by abnormal proliferation of skin and periosteal tissues involving the extremities and characterized by three clinical features: digital clubbing (also termed Hippocratic fingers), periostosis of tubular bones, and synovial effusions. HOA can be a primary entity, known as pachydermoperiostosis, or can be secondary to extraskeletal conditions, with different prognoses and management implications for each. There is a high association between secondary HOA and malignancy, especially non-small cell lung cancer. In such cases, it can be considered a form of paraneoplastic syndrome. The most prevalent secondary causes of HOA are pulmonary in origin, which is why this condition was formerly referred to as hypertrophic pulmonary osteoarthropathy. HOA can also be associated with pleural, mediastinal, and cardiovascular causes, as well as extrathoracic conditions such as gastrointestinal tumors and infections, cirrhosis, and inflammatory bowel disease. Although the skeletal manifestations of HOA are most commonly detected with radiography, abnormalities can also be identified with other modalities such as computed tomography, magnetic resonance imaging, and bone scintigraphy. The authors summarize the pathogenesis, classification, causes, and symptoms and signs of HOA, including the genetics underlying the primary form (pachydermoperiostosis); describe key findings of HOA found at various imaging modalities, with examples of underlying causative conditions; and discuss features differentiating HOA from other causes of multifocal periostitis, such as thyroid acropachy, hypervitaminosis A, chronic venous insufficiency, voriconazole-induced periostitis, progressive diaphyseal dysplasia, and neoplastic causes such as lymphoma. RSNA, 2016.

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Section: Clinical Presentation Of Hoamentioning

confidence: 99%

Hypertrophic Osteoarthropathy: Clinical and Imaging Features

Yap¹,

Skalski²,

Patel³

et al. 2017

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“…It is usually associated to digital clubbing (Benedek, 1993;Gibb et al, 2013), but it is still discussed whether HOA and digital clubbing are the same entity in different evolutive stages (Pineda et al, 1985), or different diseases (Sarkar et al, 2012). Chronic hypoxemia leads to increased levels of platelet-derived growth factor (PDGF) and vascular-endothelial growth factor (VEGF; Silveira et al, 2000), which can also be autonomously secreted by neoplastic tissue (as angiogenic factors).…”

Section: Hypertrophic Osteoarthropathy (Hoa)mentioning

confidence: 99%