Clusterin antisense complexed with chitosan for controlled intratumoral delivery

Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery

“…27 An intratumoral injection of chemotherapeutic agents is potentially a more effective alternative to systemic administration, because direct delivery of the anticancer drug to the target may improve both the stability and the efficacy of anticancer drugs. 28 Such targeted delivery would be expected to provide a high local concentration of agents, reducing systemic drug levels and thereby decreasing the incidence of side effects compared with traditional treatments.…”

In vivo efficacy of paclitaxel-loaded injectable in situ-forming gel against subcutaneous tumor growth

“…However, local recurrence of tumors generally occurs near the site of the previous surgical excision. Intratumoral injection of anticancer agents has been proposed by several investigators as one treatment option for preventing this phenomenon (Pawar et al, 2004;Ranganath and Wang, 2008;Springate et al, 2008;Lee et al, 2009). An important feature of a successful engineering solution employing intratumoral injection is the development of a drug depot at the injected site.…”

The use of nanocrystalline cellulose for the binding and controlled release of drugs

“…Other workers have described the use of chitosan, a positively charged insoluble polysaccharide, as a binding agent for the controlled release of negatively charged antisense oligonucleotide (ASO) drugs. 15,16 In such studies, the chitosan/ASO complexes were used either alone or dispersed in a polymeric vehicle for the treatment of cancer.…”

“…Such methods rely on a charge interaction between the positive charge on amine groups of each sugar residue in chitosan with negatively charged drugs such as antisense o ligonucleotides. 15,16 The high positive and negative charges on chitosan and oligonucleotides respectively, allow for a strong binding interaction between the carrier and the drug so that phosphate counterions tend to release a weakly bound fraction rapidly and a tightly bound fraction very slowly. 16 Nanocrystalline cellulose (NCC) is extracted from lignocellulosics by acidic extraction methods resulting in the formation of nanodimensional cellulose rods, termed crystallites, with a very high surface to volume ratio.…”

“…15,16 The high positive and negative charges on chitosan and oligonucleotides respectively, allow for a strong binding interaction between the carrier and the drug so that phosphate counterions tend to release a weakly bound fraction rapidly and a tightly bound fraction very slowly. 16 Nanocrystalline cellulose (NCC) is extracted from lignocellulosics by acidic extraction methods resulting in the formation of nanodimensional cellulose rods, termed crystallites, with a very high surface to volume ratio. 17 Due to its large surface area, high aspect ratio, and tremendous stiffness and strength, NCC is actively being investigated as a nanocomposite material.…”