Clusterin inhibits Aβ₄₂ aggregation through a “strawberry model” as detected by FRET‐FCS

Abstract

Alzheimer's disease (AD), the most common type of dementia among older people, is an irreversible, progressive neurodegenerative disease (Masliah et al., 1991;Scheltens et al., 2016;Wong et al., 1985). With an aging global population, AD is not only a chronic medical problem but also a social and economic matter.Although the exact etiology and pathogenesis of AD are poorly understood, the dominant proposal is still the amyloid hypothesis, which states that the aggregation of amyloid beta peptide