Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Kolářová, Lenka; Prokeš, Lubomı́r; Kučera, Lukáš; Hampl, Aleš; Peña‐Méndez, Eladia María; Vaňhara, Petr; Havel, Josef

doi:10.1007/s13361-016-1567-x

Cited by 33 publications

(20 citation statements)

References 33 publications

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“…The phosphorus clusters detected were in agreement with previous results of Bulgakov et al and Sladkova et al Previously, we reported that phosphorus clusters can provide a wide range of masses and are highly promising as a calibrants for complex samples, e.g. biological fluids or peptide mixtures, and, moreover, they can even serve as a suitable matrix . An overview of the intensity distribution of the clusters is shown in Figure .…”

Section: Resultssupporting

confidence: 91%

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Laser ablation synthesis of carbon–phosphides from graphene/nanodiamond–phosphorus composite precursors: Laser desorption ionisation time‐of‐flight mass spectrometry

Mandal

Vaňhara

Havel

2019

Rapid Comm Mass Spectrometry

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Rationale Carbon–phosphides are new and promising strategic materials with applications e.g. in optoelectronics. However, their chemistry and methods of synthesis are not completely understood, and only a limited number of C–P clusters have been detected up to now. Laser ablation synthesis (LAS) or laser desorption ionisation (LDI) has great potential to generate CmPn clusters in the gas phase and to act as the basis for the development of new technology. Methods The LAS of carbon phosphides using mixtures of nano‐carbon sources (graphene, nanodiamonds) with phosphorus allotropes (red, black, and phosphorene) was examined. Since phosphorene is not commercially available, it was synthesised. A reflectron time‐of‐flight mass spectrometer was used to produce and identify the C–P clusters. A transmission electron microscope was used to characterise the prepared composites. Results LDI of various carbon–phosphorus composites generated a range of carbon–phosphides. From graphene–red phosphorus, CmP+ (m = 3–47), CmP2+ (m = 2–44), CmP3+ (m = 1–42), CmP4+ (m = 1–39), CmP5+ (m = 1–37), CmP6+ (m = 1–34), CmP7+ (m = 1–31), CmP8+ (m = 1–29), CmP9+ (m = 1–26), CmP10+ (m = 1–24), CmP11+ (m = 1–21), and CmP12+ (m = 1–19) clusters were detected, while nanodiamond composites with red/black phosphorus and with phosphorene yielded C24P5 + 2n+ (n = 0–28), C24P5 + 2n+ (n = 0–16), and C24P5 + 2n+ (n = 0–14) clusters, respectively. In total, over 300 new carbon–phosphide clusters were generated. Conclusions The novel series of carbon–phosphide clusters generated from graphene or nanodiamond composites with red/black phosphorus or with phosphorene demonstrated rich carbon–phosphide chemistry that might inspire the development of novel nano‐materials with specific properties.

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Section: Resultssupporting

confidence: 91%

“…biological fluids or peptide mixtures, and, moreover, they can even serve as a suitable matrix. 25 An overview of the intensity distribution of the clusters is shown in Figure 4. All spectra were accumulated using 1000 profiles (laser shots).…”

Section: Mass Spectra Of Phosphorus Allotropesmentioning

confidence: 99%

Laser ablation synthesis of carbon–phosphides from graphene/nanodiamond–phosphorus composite precursors: Laser desorption ionisation time‐of‐flight mass spectrometry

Mandal

Vaňhara

Havel

2019

Rapid Comm Mass Spectrometry

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“…Spectra were recorded using the reflectron in positive and negative ion mode in the m/z ranges of 100–400, 250–1200, and 800–3500. Calibration was carried out using red phosphorus clusters . A stainless steel sample target was used, containing 384 sample spots with a diameter of 2.8 mm.…”

Section: Methodssupporting

confidence: 90%

Gallium selenide clusters generated via laser desorption ionisation quadrupole ion trap time‐of‐flight mass spectrometry

Pečínka¹,

Prokeš

Havel³

2019

Rapid Comm Mass Spectrometry

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Rationale Gallium selenide thin films important for electronics and phase‐change materials are prepared via pulsed laser deposition (PLD); however, there are no studies concerning the analysis of gallium selenide clusters formed in the gas phase. Laser desorption ionisation (LDI) combined with time‐of‐flight mass spectrometry (TOF‐MS) has great potential to generate charged GamSen clusters, to analyse them and thus to develop new materials. Methods LDI of Ga‐Se mixtures using a pulsed laser (337 nm nitrogen) was used to generate gallium‐selenide clusters. Mass spectra were recorded (in positive and negative ion mode) on a TOF mass spectrometer equipped with a quadrupole ion trap and reflectron mass analyser. Results Ga‐Se mixtures were found to be suitable for laser ablation synthesis (LAS) of gallium selenide clusters, although their composition was strongly dependent on the laser energy. The effect of laser energy on the stoichiometry of the generated clusters was established. In total, over 100 gallium selenide GamSen clusters were generated and identified from Ga‐Se mixtures. LDI of Ga2Se3 crystals showed almost the same clusters up to m/z 1000 with lower intensities, whereas no clusters from Ga2Se3 were observed above m/z 1000. Conclusions A family of over 100 gallium selenide clusters, generated and identified for the first time, shows rich and complex chemistry. Some of the clusters represent new compounds that have the potential to be used in the development of advanced materials.

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“…Overlapping MS peaks are common in complex samples like biological tissues when analyzed without a previous chromatographic separation stage. This results in a reduction of mass accuracy for TOF instruments preventing to obtain mass errors in the range of 5 ppm as described for non-overlapping MS signals[39].…”

Section: Results: Msi Of Animal Tissues With Gold-sputtered Layersmentioning

confidence: 99%

Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications

et al. 2018

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Mass spectrometry imaging (MSI) is a molecular imaging technique that maps the distribution of molecules in biological tissues with high spatial resolution. The most widely used MSI modality is matrix-assisted laser desorption/ionization (MALDI), mainly due to the large variety of analyte classes amenable for MALDI analysis. However, the organic matrices used in classical MALDI may impact the quality of the molecular images due to limited lateral resolution and strong background noise in the low mass range, hindering its use in metabolomics. Here we present a matrix-free laser desorption/ionization (LDI) technique based on the deposition of gold nanolayers on tissue sections by means of sputter-coating. This gold coating method is quick, fully automated, reproducible, and allows growing highly controlled gold nanolayers, necessary for high quality and high resolution MS image acquisition. The performance of the developed method has been tested through the acquisition of MS images of brain tissues. The obtained spectra showed a high number of MS peaks in the low mass region (m/z below 1000 Da) with few background peaks, demonstrating the ability of the sputtered gold nanolayers of promoting the desorption/ionization of a wide range of metabolites. These results, together with the reliable MS spectrum calibration using gold peaks, make the developed method a valuable alternative for MSI applications.

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Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Cited by 33 publications

References 33 publications

Laser ablation synthesis of carbon–phosphides from graphene/nanodiamond–phosphorus composite precursors: Laser desorption ionisation time‐of‐flight mass spectrometry

Laser ablation synthesis of carbon–phosphides from graphene/nanodiamond–phosphorus composite precursors: Laser desorption ionisation time‐of‐flight mass spectrometry

Gallium selenide clusters generated via laser desorption ionisation quadrupole ion trap time‐of‐flight mass spectrometry

Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications

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