CMDH4 encodes a protein that is required for lead tolerance in Arabidopsis

Yang, Libo; Fan, Tingting; Guan, Lingxia; Ren, Yongbing; Han, Yi; Liu, Quoqing; Liu, Yongsheng; Cao, Shuqing

doi:10.1007/s11104-016-3078-8

Cited by 9 publications

(3 citation statements)

References 60 publications

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“…ABC transporter of the mitochondria 3 (ATM3) [260][261][262], acyl-CoA-binding protein [263], and leucine-rich repeat2 (LRR2) and ethylene-insensitive 2 (EIN2) [264] are also important to regulate Pb transportation to the exterior of the cell [19,265]. A cytosol-localized malate dehydrogenase (CMDH4) protein functions as regulation of Pb tolerance mechanisms [19,266]. Pb is easily affected by GSH reductase in the plant cell [267].…”

Section: Biotechnological and Genetic Approachesmentioning

confidence: 99%

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Kumar

Pinto

Chaturvedi

et al. 2020

IJERPH

631

229

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Lead (Pb) toxicity has been a subject of interest for environmental scientists due to its toxic effect on plants, animals, and humans. An increase in several Pb related industrial activities and use of Pb containing products such as agrochemicals, oil and paint, mining, etc. can lead to Pb contamination in the environment and thereby, can enter the food chain. Being one of the most toxic heavy metals, Pb ingestion via the food chain has proven to be a potential health hazard for plants and humans. The current review aims to summarize the research updates on Pb toxicity and its effects on plants, soil, and human health. Relevant literature from the past 20 years encompassing comprehensive details on Pb toxicity has been considered with key issues such as i) Pb bioavailability in soil, ii) Pb biomagnification, and iii) Pb- remediation, which has been addressed in detail through physical, chemical, and biological lenses. In the review, among different Pb-remediation approaches, we have highlighted certain advanced approaches such as microbial assisted phytoremediation which could possibly minimize the Pb load from the resources in a sustainable manner and would be a viable option to ensure a safe food production system.

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Section: Biotechnological and Genetic Approachesmentioning

confidence: 99%

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Kumar

Pinto

Chaturvedi

et al. 2020

IJERPH

631

229

View full text Add to dashboard Cite

show abstract

“…Previous data also supported the higher production of H 2 O 2 in T. aestivum (10) and T. triangulae (53); Armeria maritima (61); Coronopus The EuroBiotech Journal didymus (14). Arabidopsis mutants showed Pb hypersensivity and elevated levels of H 2 O 2 compared to wild type plants (62).…”

Section: Discussionmentioning

confidence: 54%

Defense manifestations of enzymatic and non-enzymatic antioxidants in Ricinus communis L. exposed to lead in hydroponics

Kiran

Prasad

2019

The EuroBiotech Journal

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Lead (Pb) is a major inorganic pollutant with no biological significance and has been a global concern. Phytotoxicity of lead induces toxic effects by generating reactive oxygen species (ROS), which inhibits most of the cellular processes in plants. Hydro-ponic experiments were performed with Ricinus communis to investigate the toxicity and antioxidant responses by exposing to different concentrations of lead (0, 200 and 400 µM) for 10 days. Pb stress caused a significant increase in electrolyte leakage, non-enzymatic antioxidants (phenols and flavonoids) and a decrease in the elemental profile of the plant. Histochemical visualization clearly indicates the significant increase of H2O2 production in dose-dependent manner under Pb stress. Likewise, an increase in catalase, guaiacol peroxidase and superoxide dismutase activity was also evident. Ascorbate peroxidase and MDAR, on the other hand, responded biphasically to Pb treatments showing a decrease in concentration. The decline in redox ratio GSH/GSSG was imposed by the indirect oxidative stress of Pb. Hence these findings showed the ameliorative potential of R. communis to sustain Pb toxicity under oxidative stress.

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“…Likewise, as a proof-of-concept for potential transfer to crop species, it has been demonstrated that overexpression of MDH1 from Stylosanthes guianensis participates in Mn (5-800 µM MnSO 4 ) detoxification by improving malate synthesis and exudation in Arabidopsis roots, thus lowering plant Mn concentrations in plants exposed to Mn stress [69]. Additionally, in the same plant model, cytosolic MDH (CMDH4) is required for Pb tolerance, enhancing the transcription of PDR12 required for Pb efflux [70].…”

Section: Malic Acidmentioning

confidence: 99%

Increasing Heavy Metal Tolerance by the Exogenous Application of Organic Acids

Vega

Delgado

Handford

2022

IJMS

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Several metals belong to a group of non-biodegradable inorganic constituents that, at low concentrations, play fundamental roles as essential micronutrients for the growth and development of plants. However, in high concentrations they can have toxic and/or mutagenic effects, which can be counteracted by natural chemical compounds called chelators. Chelators have a diversity of chemical structures; many are organic acids, including carboxylic acids and cyclic phenolic acids. The exogenous application of such compounds is a non-genetic approach, which is proving to be a successful strategy to reduce damage caused by heavy metal toxicity. In this review, we will present the latest literature on the exogenous addition of both carboxylic acids, including the Kreb’s Cycle intermediates citric and malic acid, as well as oxalic acid, lipoic acid, and phenolic acids (gallic and caffeic acid). The use of two non-traditional organic acids, the phytohormones jasmonic and salicylic acids, is also discussed. We place particular emphasis on physiological and molecular responses, and their impact in increasing heavy metal tolerance, especially in crop species.

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CMDH4 encodes a protein that is required for lead tolerance in Arabidopsis

Cited by 9 publications

References 60 publications

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Defense manifestations of enzymatic and non-enzymatic antioxidants in Ricinus communis L. exposed to lead in hydroponics

Increasing Heavy Metal Tolerance by the Exogenous Application of Organic Acids

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