CMTM3 as a Potential New Immune Checkpoint Regulator

Shen, Qian; Cong, Zhirong; Zhou, Ying; Teng, Yue; Gao, Jin; Tang, Weiyan

doi:10.1155/2022/2103515

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…CLEC11A is a protein-coding gene that signi cantly participates in the tumor microenvironment and immune cell communication and can predict protein survival in laryngeal squamous cell carcinoma (LSCC) (27). CMTM3 was associated with cell growth and migration in oral squamous cell carcinoma (28) and pancreatic cancer (29) and has roles in the tumor microenvironment and cancer immunotherapy (30). COLGALT1 was identi ed as a biomarker for predicting prognosis and immune responses for kidney renal clear cell carcinoma (31).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Lai,

Wang,

et al. 2023

Preprint

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Background Head and neck cancer (HNC) is the most common worldwide. Radiation therapy plays an important role in treating HNC. MicroRNAs (miRNAs) have been associated with tumor progression and radiosensitivity. However, their mechanisms remain largely unknown, and the evidence remains limited. This study aimed to identify miRNAs associated with the radiosensitivity of head and neck tumor cells, leading to the poor prognosis of patients with HNC receiving radiation therapy. The miRNA expression profiles and clinical information of patients with HNC were obtained from The Cancer Genome Atlas. The miRNAs were identified through an integrated bioinformatics analysis and validated through in vitro and in vivo studies. Results MiR-4776-5p was identified as a radiosensitizer and predictor of the prognosis of patients with HNC receiving radiotherapy. Eleven of 16 genes targeted by miR-4776-5p were found to regulate mechanisms related to radiosensitivity via functional annotation. Conclusion In this study, we identified a miRNA, miR-4776-5p, related to the clinical outcome of patients with HNSC receiving RT alone, which could be potentially selected as a miRNA-based therapeutic target to block radioresistant characteristics and lead to better treatment outcomes for HNC.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Lai,

Wang,

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…CLEC11A is a protein coding gene significantly participating in tumor microenvironment and immune cells' communication, and can predict the survival of protein in laryngeal squamous cell carcinoma (LSCC) [27] . CMTM3 is not only related to the cell growth and migration of oral squamous cell carcinoma [28] and pancreatic cancer [29], but also has the role in tumor microenvironment and cancer immunotherapy [30]. COLGALT1 has been reported as a biomarker for predicting prognosis and immune responses for kidney renal clear cell carcinoma [31].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Lai

Wang

Lin

et al. 2022

Preprint

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Head and neck cancer is the leading cancer worldwide. Radiation therapy plays important role of treatment for head and neck cancer. MicroRNAs have been shown to be related to tumor progression and radiosensitivity. However, the mechanisms are still largely unknown and evidence are still limited. In the current study, we sought to identify the miRNA related the radiosensi-tivity of head and neck tumor cell, which leading to the disappointed prognosis of patients with head and neck cancer receiving radiation therapy. The miRNA expression profiles and clinical information of patients with head and neck cancer were obtained from The Cancer Genome Atlas. The identification of miRNA was carried out through an integrated bioinformatics analysis. The miRNA identified in previous approach was validated through in vitro and in vivo studies. MiR-4776-5p was finally identified as the role of radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy. 11 of 16 genes targeted by the miR-4776-5p have been discovered to regulate the mechanisms related to radiosensitivity using functional annotation.

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CMTM3 regulates neutrophil activation and aggravates sepsis through TLR4 signaling

Xue,

Xiao,

Zhao

et al. 2024

EMBO Rep

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Regulation of neutrophil activation plays a significant role in managing sepsis. CKLF-like MARVEL transmembrane domain containing (CMTM)3 is a membrane protein involved in immune response. Here, we find that CMTM3 expression is elevated in sepsis and plays a crucial role in mediating the imbalance of neutrophil migration. Cmtm3 knockout improves the survival rate of septic mice, mitigate inflammatory responses, and ameliorate organ damage. Mechanistically, the deletion of Cmtm3 reduced the expression of Toll-like receptor 4 (TLR4) on neutrophils, leading to a decrease in the expression of C-X-C motif chemokine receptor 2 (CXCR2) on the cell membrane. This resulted in a reduced migration of neutrophils from the bone marrow to the bloodstream, thereby attenuating their recruitment to vital organs. Our findings suggest that targeting CMTM3 holds promise as a therapeutic approach to ameliorate the dysregulation of neutrophil migration and multi-organ damage associated with sepsis.

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CMTM3 as a Potential New Immune Checkpoint Regulator

Cited by 5 publications

References 28 publications

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

CMTM3 regulates neutrophil activation and aggravates sepsis through TLR4 signaling

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