CNS Involvement in Children With Newly Diagnosed Non-Hodgkin’s Lymphoma

Sandlund, John T.; Murphy, Sharon B.; Santana, Víctor M.; Behm, Frederick G.; Jones, Dana; Berard, Costan W.; Furman, Wayne L.; Ribeiro, Raul C.; Crist, William M.; Greenwald, Carol; Chen, Gang; Walter, Andrew W.; Pui, Ching Hon

doi:10.1200/jco.2000.18.16.3018

Cited by 35 publications

(23 citation statements)

References 17 publications

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“…Although the abdominal and bone marrow involvement resembled more closely the American form 14,23 , bone lesions and CNS invasion, which are less often encountered in the sporadic form 16,18 , are more similar to the findings of African BL 8 .…”

Section: Discussionmentioning

confidence: 55%

Oral Burkitt's lymphoma in children: the Moroccan experience

Otmani¹,

Khattab²

2008

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 55%

Oral Burkitt's lymphoma in children: the Moroccan experience

Otmani¹,

Khattab²

2008

International Journal of Oral and Maxillofacial Surgery

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“…Other clinically aggressive lymphomas such as lymphoblastic and Burkitt-type lymphomas reportedly involve the CNS in 7-13% of cases at diagnosis and in 16.5-39% during the course of disease (23,24). However, because current clinical staging protocols and evaluations of MCL patients do not routinely include CSF examination as do the protocols for other aggressive lymphomas, the data needed to accurately characterize the true incidence of CSF involvement in MCL are not currently available.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Involvement in Mantle Cell Lymphoma

et al. 2002

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Mantle cell lymphoma (MCL) is an aggressive neoplasm that is incurable by standard therapy. Patients often present with high-stage disease (Stages III-IV) and frequently have involvement at multiple extranodal sites. Although the gastrointestinal tract, spleen, lung, pleura, bone marrow, and peripheral blood are among the most commonly involved tissues, MCL may also disseminate to so-called sanctuary sites including the central nervous system. Despite this, current clinical evaluations do not routinely include assessment of the cerebrospinal fluid (CSF) for lymphomatous infiltrates at presentation, and moreover, only few authors have specifically examined CSF involvement in MCL. In this study, we reviewed the medical records of 108 patients with MCL seen at three centers over a 5-year period to determine the rate of CSF sampling and the frequency of CSF involvement by MCL. The clinical and cytologic characteristics associated with CSF involvement were also studied. Central nervous system (CNS) signs and/or symptoms prompted CSF sampling in 25/108 patients (23%). Specific radiographic abnormalities were present in 9/25 patients (36%). CSF involvement by MCL was identified in 10 of the 25 CSF-sampled patients (40%) by morphology (3 patients), flow cytometry alone (1 patients), or both (6 patients). The CSF-positive cases included two blastoid variants. The CSF cytology of the nine morphologically positive cases was pleomorphic, and prominent cytoplasmic granules were observed in two cases. The overall rate of CSF involvement by MCL among the cohort was 9%, which is comparable to that reported in other selected studies examining this issue.

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“…The incidence of leptomeningeal disease at diagnosis ranges from 3.7% to 25%, and it is related to several factors, such as the different histological subtypes, the involvement of particular sites of disease (ie, testis, bone marrow, Waldeyer ring, or retroperitoneal masses), and an increased serum lactate dehydrogenase (LDH) level. [1][2][3][4][5][6][7][8][9][10][11] Moreover, the overall incidence of CNS recurrence with or without intrathecal prophylaxis is around 5%. 3,[12][13][14][15] Since the beginning of the acquired immune deficiency syndrome (AIDS) epidemic, a close association between human immunodeficiency virus (HIV) infection and high-grade NHL has been reported.…”

mentioning

confidence: 99%

Phase 2 study of intrathecal, long‐acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus‐related non‐Hodgkin lymphoma

Spina

Chimienti

Martellotta

et al. 2010

Cancer

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BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) develop central nervous system (CNS) progression or recurrence during the course of their disease. Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown activity in lymphomatous meningitis, but there are limited data for prophylaxis. METHODS: Between May 2006 and December 2008, a phase 2 study of intrathecal liposomal cytarabine was performed at the dose of 50 mg in 30 patients with HIV-NHL, with the aim of evaluating feasibility and activity for prophylaxis. RESULTS: Liposomal cytarabine was well tolerated, with headache grade I to III being the most frequent side effect in 40% of patients. With a median followup of 10.5 months, only 1 (3%) patient developed a combined systemic and meningeal recurrence. The use of liposomal cytarabine allowed significant reduction of the number of lumbar injections in comparison to the standard schedules (around 50%), improving the quality of life of patients and reducing the professional exposure risk. CONCLUSIONS: In this first study on prophylaxis of lymphomatous meningitis in HIV-NHL, liposomal cytarabine seems safe and active; it reduces by approximately 50% the number of lumbar punctures, and exposure risk for health staff as well.

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CNS Involvement in Children With Newly Diagnosed Non-Hodgkin’s Lymphoma

Abstract: A greater tumor burden at diagnosis adversely influences the treatment outcome of children with NHL and CNS disease at diagnosis, suggesting a need for ongoing improvement in both systemic and CNS-directed therapy.

Cited by 35 publications

References 17 publications

Oral Burkitt's lymphoma in children: the Moroccan experience

Oral Burkitt's lymphoma in children: the Moroccan experience

Cerebrospinal Fluid Involvement in Mantle Cell Lymphoma

Phase 2 study of intrathecal, long‐acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus‐related non‐Hodgkin lymphoma

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