Co-infection by Salmonella enterica subsp. Enterica serovar typhimurium and Entamoeba dispar pathogenic strains enhances colitis and the expression of amoebic virulence factors

Oliveira, Fabrício Marcus Silva; Fernandes, Ana Claúdia de Carvalho; Sandes, S.H.C.; Prata, Luana Oliveira; Abatemarco, Mário; Silva, Cezar Augusto Vilela da; Campolina-Silva, Gabriel Henrique; Oliveira, Marcel Lorenzo de Jesus; Oliveira, Cleida A.; Neumann, Elizabeth; Nunes, Álvaro Cantini; Gomes, Maria Aparecida; Caliari, Marcelo Vidigal

doi:10.1016/j.micpath.2021.105010

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…Our group have been able to reproduce experimental lesions in animals inoculated with E. dispar, which associates with the host's original intestinal microbiota [26,[37][38][39][40][41][42][43]. Such data suggest that bacteria could transfer some type of virulence factor to trophozoites or otherwise favour the development of these lesions [37].…”

Section: Virulence Factors and Pathogenesismentioning

confidence: 84%

“…Following this reasoning, we investigated whether Salmonella typhimurium could induce changes in the amoebic virulence phenotype. In fact, we observed that S. typhimurium coinfection exacerbated amoebic colitis and intestinal inflammation, and the in-vitro association of S. typhimurium and E. dispar trophozoites contributed to the increased expression of amoebic virulence factors amoebapore A, CP5, and the CD59-like lectin [42].…”

Section: Virulence Factors and Pathogenesismentioning

confidence: 87%

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Amoebiasis and probiotics: perspectives on complementary treatment

Oliveira,

Prado,

Cruz

et al. 2023

Reviews and Research in Medical Microbiology

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Amoebiasis is a disease caused by the protozoan parasite Entamoeba histolytica that has a worldwide geographic distribution, with a higher prevalence in developing countries where social and sanitary conditions are considerably precarious. Amoebiasis can be accompanied by severe clinical manifestations such as amoebic colitis and amoebic liver abscess, aggravating the host's condition, with death as one of the consequences. Several health actions and pharmacological strategies have been made to prevent the infection and possible complications of this disease, and have achieved success in containing the disease in most patients. However, some medications such as metronidazole can also cause serious complications to the individual because of their potential hepatotoxic effect in addition to producing other side effects. Research directed towards an alternative and effective treatment for amebiasis has been conducted. The use of probiotics has been highlighted as a promising treatment against Entamoeba spp. In this review, we will address the prospects of using probiotics as a treatment for amoebiasis patients. In addition, we will provide information on the biology of Entameba spp.; the clinical manifestations of amoebiasis and a perspective of the use of Weissella paramesenteroides as a possible treatment.

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Section: Virulence Factors and Pathogenesismentioning

confidence: 84%

Section: Virulence Factors and Pathogenesismentioning

confidence: 87%

Amoebiasis and probiotics: perspectives on complementary treatment

Oliveira,

Prado,

Cruz

et al. 2023

Reviews and Research in Medical Microbiology

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“…Furthermore, Reyna-Fabian (2010) [35] showed that E. dispar in association with the gut microbiota could be potentially responsible for intestinal or liver tissue damage, like that observed in E. histolytica. More recently, Vilela da Silva et al ( 2021) reported new evidence about some E. dispar strains in that the cysteine proteinase 5 expression in E. dispar MCR, VEJ, and ADO strains, isolated in Brazil, show that S. typhimurium and E. dispar co-infection worsens amoebic colitis, possibly by increasing the expression of amoebic virulence factors [112]. However, great effort is still required to elucidate the factors that drove these interactions relevant to the development of the disease caused by E. dispar.…”

Section: Intestinal Ecosystem and Entamoeba Interactionsmentioning

confidence: 99%

Amoebiasis: Advances in Diagnosis, Treatment, Immunology Features and the Interaction with the Intestinal Ecosystem

Morán

Serrano-Vázquez

Rojas-Velázquez

et al. 2023

IJMS

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This review of human amoebiasis is based on the most current knowledge of pathogenesis, diagnosis, treatment, and Entamoeba/microbiota interactions. The most relevant findings during this last decade about the Entamoeba parasite and the disease are related to the possibility of culturing trophozoites of different isolates from infected individuals that allowed the characterization of the multiple pathogenic mechanisms of the parasite and the understanding of the host–parasite relationship in the human. Second, the considerable advances in molecular biology and genetics help us to analyze the genome of Entamoeba, their genetic diversity, and the association of specific genotypes with the different amoebic forms of human amoebiasis. Based on this knowledge, culture and/or molecular diagnostic strategies are now available to determine the Entamoeba species and genotype responsible for invasive intestinal or extraintestinal amoebiasis cases. Likewise, the extensive knowledge of the immune response in amoebiasis with the appearance of new technologies made it possible to design diagnostic tools now available worldwide. Finally, the understanding of the interaction between the Entamoeba species and the intestinal microbiota aids the understanding of the ecology of this parasite in the human environment. These relevant findings will be discussed in this review.

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