Co‐initiating function of silk peptide in free radical photopolymerization

Nan, Xuying; Huang, Yi; Shao, Jianzhong; Yan, Huiqiong; Wu, Mingshu; Yao, Yuhua

doi:10.1002/pen.24833

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Of note, many amino acids and nucleotides, the structural building blocks for proteins and DNA, respectively, contain tertiary amine functional groups and may act as synergists in Type II photopolymerization reactions. 13,36,37 For example, Kim and Chu investigated the use of the amino acid arginine, in combination with riboflavin to polymerize hydrogels. They worked to optimize the ratios of riboflavin and arginine to increase the physical stability of the resulting hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the polymerization effectiveness and biocompatibility of bio‐sourced, visible light‐based photoinitiator systems

Wendland,

Conway,

Worthington

2024

J Biomedical Materials Res

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The use of photopolymerization is expanding across a multitude of biomedical applications, from drug delivery to bioprinting. Many of these current and emerging photopolymerization systems employ visible light, as motivated by safety and energy efficiency considerations. However, the “library” of visible light initiators is limited compared with the wealth of options available for UV polymerization. Furthermore, the synthesis of traditional photoinitiators relies on diminishing raw materials, and several traditional photoinitiators are considered emerging environmental contaminants. As such, there has been recent focus on identifying and characterizing biologically sourced, visible light‐based photoinitiator systems that can be effectively used in photopolymerization applications. In this regard, several bio‐sourced molecules have been shown to act as photoinitiators, primarily through Type II photoinitiation mechanisms. However, whether bio‐sourced molecules can also act as effective synergists in these reactions remains unknown. In this study, we evaluated the effectiveness of bio‐sourced synergist candidates, with a focus on amino acids, due to their amine functional groups, in combination with two bio‐sourced photoinitiator molecules: riboflavin and curcumin. We tested the effectiveness of these photoinitiator systems under both violet (405 nm) and blue (460–475 nm) light using photo‐rheology. We found that several synergist candidates, namely lysine, arginine, and histidine, increased the polymerization effectiveness of riboflavin when used with both violet and blue light. With curcumin, we found that almost all tested synergist candidates slightly decreased the polymerization effectiveness compared with curcumin alone under both light sources. These results show that bio‐sourced molecules have the potential to be used as synergists with bio‐sourced photoinitiators in visible light photopolymerization. However, more work must be done to fully characterize these reactions and to investigate more synergist candidates. Ultimately, this information is expected to expand the range of available visible light‐based photoinitiator systems and increase their sustainability.

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Section: Introductionmentioning

confidence: 99%

Evaluating the polymerization effectiveness and biocompatibility of bio‐sourced, visible light‐based photoinitiator systems

Wendland,

Conway,

Worthington

2024

J Biomedical Materials Res

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“…Silk peptide is a biocompatible peptide, which can initiate free radical photopolymerization in the presence of camphorquinone. However, its initiation efficiency as co‐initiator is unsatisfactory [ 11 ] .…”

Section: Introductionmentioning

confidence: 99%

Glycine ester ionic liquid as new co‐initiator used in initiating radical and cationic photopolymerization

Nan

Luo

et al. 2022

Polymer Engineering & Sci

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Ionic liquids using amino acid ester as cations is a new generation of green ionic liquids. It is found for the first time that they can be used as co-initiators to initiate radical photopolymerization in the presence of commercial type II sensitizer, camphorquinone (CQ) under mild irradiation conditions. To intensively investigate this new function, we synthesized a series of glycine ester ionic liquids by a very simple method, and then evaluated their performance as co-initiators in radical photopolymerization. The polymerization studies show that their coinitiation abilities depend strongly on the structures of N-terminal substituents and ester groups, as well as the type of anion moiety. And the pH values of the formula also have a heavy influence on their performances. More interestingly, when a small amount of hydroxyethyl acrylate (HEA) was added, under irradiation this multicomponent system composed of CQ, ionic liquids when anion moiety is PF 6 À , BF 4 À or SbF 6 À , and HEA, can release H + to initiate cationic polymerization. These facts demonstrated that the investigated glycine ester ionic liquids can be considered as valid, environmentally friendly alternatives to toxic aromatic amines co-initiators. Besides, the corresponding photoinitiation mechanism is suggested.

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Dark polymerization of acrylamide induced by tyrosine-containing peptide

Nan

Sun

et al. 2020

Polym. Bull.

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Co‐initiating function of silk peptide in free radical photopolymerization

Cited by 5 publications

References 27 publications

Evaluating the polymerization effectiveness and biocompatibility of bio‐sourced, visible light‐based photoinitiator systems

Evaluating the polymerization effectiveness and biocompatibility of bio‐sourced, visible light‐based photoinitiator systems

Glycine ester ionic liquid as new co‐initiator used in initiating radical and cationic photopolymerization

Dark polymerization of acrylamide induced by tyrosine-containing peptide

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