Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration

Feng, Chun; Xue, Jie; Yu, Xiaopeng; Zhai, Dong; Lin, Rongcai; Zhang, Meng; Xia, Lunguo; Wang, Xiaoya; Yao, Qingqiang; Chang, Jiang; Wu, Chengtie

doi:10.1016/j.actbio.2020.11.010

Cited by 59 publications

(36 citation statements)

References 75 publications

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“…Previously, the failure of implants to heal large bone defects was often attributed to insufficient bone healing, mainly due to insufficient vascularization. 51 The formation of a functional vascular system is critical for the delivery of nutrients, removal of byproducts and gas exchange. Previously, Kandhare et al 52 revealed that naringin promoted angiogenesis and inhibited endothelial apoptosis in rats with diabetic foot ulcers.…”

Section: Discussionmentioning

confidence: 99%

Naringin‐inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord‐derived mesenchymal stem cell‐based bone regeneration

Zhao

et al. 2021

Cell Proliferation

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Large bone defects caused by fracture, tumour resection and bone infection are common, debilitating clinical conditions with a substantial clinical burden. 1,2 Annually in China, over 6 million patients experience bone defects caused by trauma or various bone diseases. 3 Autologous bone grafts, allografts and artificial bone grafts are the preferred treatments for large bone defects. 4 Autologous bone grafts are the gold standard for treating bone defects. However, the bone supply is limited, and a second surgical site is required. 5 Allografts are at risk of infection and immune rejection. 6 Limitations of artificial bone grafts include osteoconductive activity, which restricts their clinical application. 7 In general, the current treatments for large bone defects remain inadequate. 8

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Section: Discussionmentioning

confidence: 99%

Naringin‐inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord‐derived mesenchymal stem cell‐based bone regeneration

Zhao

et al. 2021

Cell Proliferation

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“…Gonzalez Ocampo et al also proved nHAs promoted the cell spreading, ALP activity and matrix mineralization of human osteoblasts seeded on kappa-carrageenan ( Figure 2 c) [ 28 ]. Furthermore, nHA/polymer composites can promote bone regeneration in both calvarial defect ( Figure 2 e) [ 22 ] and long bone defect models [ 29 ]. Based on the inspiration from cortical bone and nacre, Feng et al fabricated a “brick and mortar” multilayer nHA-based scaffold, which induced not only osteogenesis, but excellent angiogenesis as well ( Figure 2 f,g) [ 29 ].…”

Section: Nano Hydroxyapatitesmentioning

confidence: 99%

“…Furthermore, nHA/polymer composites can promote bone regeneration in both calvarial defect ( Figure 2 e) [ 22 ] and long bone defect models [ 29 ]. Based on the inspiration from cortical bone and nacre, Feng et al fabricated a “brick and mortar” multilayer nHA-based scaffold, which induced not only osteogenesis, but excellent angiogenesis as well ( Figure 2 f,g) [ 29 ]. The effect of nHAs coating on metal-based nanomaterials will be briefly discussed in Section 4 .…”

Section: Nano Hydroxyapatitesmentioning

confidence: 99%

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Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration

Cui

Luo

et al. 2021

Nanomaterials

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Extensive bone defect repair remains a clinical challenge, since ideal implantable scaffolds require the integration of excellent biocompatibility, sufficient mechanical strength and high biological activity to support bone regeneration. The inorganic nanomaterial-based therapy is of great significance due to their excellent mechanical properties, adjustable biological interface and diversified functions. Calcium–phosphorus compounds, silica and metal-based materials are the most common categories of inorganic nanomaterials for bone defect repairing. Nano hydroxyapatites, similar to natural bone apatite minerals in terms of physiochemical and biological activities, are the most widely studied in the field of biomineralization. Nano silica could realize the bone-like hierarchical structure through biosilica mineralization process, and biomimetic silicifications could stimulate osteoblast activity for bone formation and also inhibit osteoclast differentiation. Novel metallic nanomaterials, including Ti, Mg, Zn and alloys, possess remarkable strength and stress absorption capacity, which could overcome the drawbacks of low mechanical properties of polymer-based materials and the brittleness of bioceramics. Moreover, the biodegradability, antibacterial activity and stem cell inducibility of metal nanomaterials can promote bone regeneration. In this review, the advantages of the novel inorganic nanomaterial-based therapy are summarized, laying the foundation for the development of novel bone regeneration strategies in future.

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“…To address these concerns and to advance the future of 3D printed BC scaffolds in the management of osteosarcoma, a progressions in materials, manufacturing techniques and clinical validations are necessary. The continuous exploration of new BC scaffolds formulations is ongoing with the goal of promoting stability, biomimicry and osteogenesis [ 87 , 88 ]. At the same time, the development of novel doping molecules to functionalize such scaffolds presents a robust field of research, with the objective to optimize the photothermal performance of the overall structure for efficient tumor removal [ 89 , 90 ].…”

Section: Challenges and Prospectsmentioning

confidence: 99%

Advances in 3D-Printed Surface-Modified Ca-Si Bioceramic Structures and Their Potential for Bone Tumor Therapy

et al. 2021

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Bioceramics such as calcium silicate (Ca-Si), have gained a lot of interest in the biomedical field due to their strength, osteogenesis capability, mechanical stability, and biocompatibility. As such, these materials are excellent candidates to promote bone and tissue regeneration along with treating bone cancer. Bioceramic scaffolds, functionalized with appropriate materials, can achieve desirable photothermal effects, opening up a bifunctional approach to osteosarcoma treatments—simultaneously killing cancerous cells while expediting healthy bone tissue regeneration. At the same time, they can also be used as vehicles and cargo structures to deliver anticancer drugs and molecules in a targeted manner to tumorous tissue. However, the traditional synthesis routes for these bioceramic scaffolds limit the macro-, micro-, and nanostructures necessary for maximal benefits for photothermal therapy and drug delivery. Therefore, a different approach to formulate bioceramic scaffolds has emerged in the form of 3D printing, which offers a sustainable, highly reproducible, and scalable method for the production of valuable biomedical materials. Here, calcium silicate (Ca-Si) is reviewed as a novel 3D printing base material, functionalized with highly photothermal materials for osteosarcoma therapy and drug delivery platforms. Consequently, this review aims to detail advances made towards functionalizing 3D-printed Ca-Si and similar bioceramic scaffold structures as well as their resulting applications for various aspects of tumor therapy, with a focus on the external surface and internal dispersion functionalization of the scaffolds.

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Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration

Cited by 59 publications

References 75 publications

Naringin‐inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord‐derived mesenchymal stem cell‐based bone regeneration

Naringin‐inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord‐derived mesenchymal stem cell‐based bone regeneration

Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration

Advances in 3D-Printed Surface-Modified Ca-Si Bioceramic Structures and Their Potential for Bone Tumor Therapy

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