Abstract-During the last few years, Wireless Body Area Networks (WBANs) have emerged into many application domains, such as medicine, sport, entertainments, military, and monitoring. This emerging networking technology can be used for e-health monitoring. In this paper, we review the literature and investigate the challenges in the development architecture of WBANs. Then, we classified the challenges of WBANs that need to be addressed for their development. Moreover, we investigate the various diseases and healthcare systems and current state-ofthe-art of applications and mainly focus on the remote monitoring for elderly and chronically diseases patients. Finally, relevant research issues and future development are discussed.