2006
DOI: 10.1159/000095059
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Co-Localization of Susceptibility Loci for Psoriasis (PSORS4) and Atopic Dermatitis (ATOD2) on Human Chromosome 1q21

Abstract: Psoriasis (PS) is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation and altered differentiation. Atopic dermatitis (ATOD) is a chronic inflammatory, pruritic and eczematous disease frequently associated with respiratory atopy. These diseases are associated with distinct immunologic abnormalities and represent typical examples of complex diseases triggered by both genetic and environmental factors, as demonstrated by independent twin studies. Genome wide linkage studies have … Show more

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Cited by 33 publications
(22 citation statements)
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“…The chromosome 1q21-q23 was found to harbor a susceptibility locus for several autoimmune diseases including SLE [10], psoriasis, and atopic dermatitis [11]. However, because of the clustering of Fc␥R II/III and FCRL genes and extended blocks of linkage disequilibrium (LD) within the gene clusters, it is difficult to resolve a true disease-associated gene variant(s) in this genomic region.…”
Section: Mapping Of the Fcrl3 To Chromosome 1q21-q22mentioning
confidence: 99%
“…The chromosome 1q21-q23 was found to harbor a susceptibility locus for several autoimmune diseases including SLE [10], psoriasis, and atopic dermatitis [11]. However, because of the clustering of Fc␥R II/III and FCRL genes and extended blocks of linkage disequilibrium (LD) within the gene clusters, it is difficult to resolve a true disease-associated gene variant(s) in this genomic region.…”
Section: Mapping Of the Fcrl3 To Chromosome 1q21-q22mentioning
confidence: 99%
“…This locus is of special interest for PsV, because it comprises the epidermal differentiation complex, a group of genes expressed in the upper strata of the epidermis. Although several genes at PSORS4-e.g., LOR, LCE1C, PGLYRP, SPRR genes, PRR9 genes, and IVL-have been suggested to account for psoriasis susceptibility (Giardina et al, 2006;Chen et al, 2009;Liu et al, 2008;Kainu et al, 2009), very recently, a CNV within the late cornified envelope (LCE) gene cluster was identified by a genome-wide scan using pooled DNAs. The deletion of two LCE genes (LCE3C and LCE3B) was shown to be at higher frequency in 1,426 psoriasis patients from several European countries than in controls and to be associated with psoriasis in a large family-based cohort (de Cid et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…While several genes at PSORS4 (for example, LOR , LCE1C , PGLYRP , SPRR genes, PRR9 genes and IVL ) have been proposed to account for psoriasis susceptibility,1518 very recently, a copy number variation (CNV) within the late cornified envelope ( LCE ) gene cluster was identified by a genome-wide scan using pooled DNAs. The deletion of 2 late cornified envelope genes ( LCE3C and LCE3B ) was shown to be enriched in 1426 patients with psoriasis and to be associated in a large family-based cohort 19.…”
Section: Introductionmentioning
confidence: 99%