Abstract:Evidence suggests that there may be racial differences in risk factors associated with the development of Alzheimer's disease and related dementias (ADRD). Using whole genome sequencing analysis, we identified the combination of 3 pathogenic variants at the heterozygous state (UNC93A: rs7739897 and WDR27: rs61740334; rs3800544) in a Peruvian family with a strong clinical history of ADRD. Remarkably, the combination of these variants was present in two generations of affected individuals but absent in healthy m… Show more
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