Co-Registered Molecular Logic Gate with a CO-Releasing Molecule Triggered by Light and Peroxide

Abstract

Co-registered molecular logic gates combine two different inputs and outputs, such as light and matter. We introduce a biocompatible CO-releasing molecule (CORM, A) as Mn(I) tricarbonyl complex with the ligand 5-(dimethylamino)-N, N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L). CO release is chaperoned by turn-on fluorescence and can be triggered by light (405 nm) as well as with hydrogen peroxide in aqueous phosphate buffer. Complex A behaves as a logic "OR" gate via co-registering the inputs of irradiation (light) and peroxide (matter) into the concomitant outputs fluorescence (light) and CO (matter). Cell viability assays confirm the low toxicity of A toward different human cell lines. The CORM has been used to track the inclusion of A into cancer cells.

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

“…Although the use of photoCORMs achieved controllable CO delivery to some extent, a crucial challenge remains in accurately monitoring the location and extent of CO release in vivo . Researchers have designed a novel photoCORMs that, in addition to releasing CO, could act as an imageable reporter allowing visualization of location and extent of CO release . As a paradigm, Carrington et al synthesized a luminescent rhenium(I) complex, [Re(H 2 O)(CO) 3 (pbt)](CF 3 SO 3 ) (pbt = 2‐(2‐pyridyl)‐benzothiazole).…”

“…Therefore, both the photoCORMs and the CO delivery step in cells can be tracked using confocal fluorescence microscopy. Recently, Gandra et al constructed a stable Mn(I) tricarbonyl complex with turn‐on fluorescence response upon release of CO, which has been utilized to track and confirm CO delivery in cellular matrices. Overall, the controlled release of CO from a few selected photoCORMs under light illumination was shown to play a beneficial therapeutic role in cancer and bacterial infection .…”

“…Compared with external stimuli‐induced CO release, the release of CO triggered by specific pathologic microenvironment (such as H 2 O 2, glutathione, cysteine, pH and enzyme) is not limited by the penetration depth and thus is more advantageous to tissue‐specific CO therapy …”

“…In addition to the controllability of CO release, the real‐time monitoring of CO release is also highly desirable but remains a great challenge . Previous studies have indicated that photoCORMs can be structurally designed as an imageable reporter to visualize the location and extent of CO release . Recently, the emergence of fluorescent nanomaterials has also become a good alternative to realize real‐time monitoring of CO release.…”

A Quadruple‐Hydrogen‐Bonded Supramolecular Binder for High‐Performance Silicon Anodes in Lithium‐Ion Batteries

“…In addition, the low discharge voltage and better safety enable silicon to be one of the most promising candidate of anodic material for new LIBs with high energy density and long cycling life . However, silicon undergoes extreme volume expansion/shrink (420%) during the repeated lithiation/delithiation process, causing extensive fracturing and fragmentation, followed by the deterioration of electrical contact with the bulk electrode, resulting in the rapid decrease of capacity and poor cycling stability . Although the nanosizing strategies of Si could accommodate the volume variation at nanoscale, the improvement of cycling stability is still limited due to the irreversible damage of electrode during the repeated charge/discharge cycles .…”