Coagulation Changes in Sickle Cell Disease in Early Childhood

Babiker, M. A.; Ashong, E.F.; Bahakim, Hassan M.; Gader, A. M. A.

doi:10.1159/000205981

Cited by 14 publications

(8 citation statements)

References 11 publications

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“…Blood samples for coagulation assays and platelet aggregation were collected and processed as already described [4,7]. Methods for prothrombin time, partial thromboplastin time, thrombin time, reptilase time, plasma fibrinogen, ATIII and platelet aggregation were described previously [4,7].…”

Section: Methodsmentioning

confidence: 99%

Haemostatic measurements in childhood nephrotic syndrome

et al. 1991

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Blood coagulation and platelet aggregation were assessed in children with nephrotic syndrome who were divided into the following groups: (1) relapse without treatment: (2) relapse on steroids; (3) early remission; (4) late remission and (5) steroid resistant. The renal histological findings were also recorded. Plasma anti-thrombin III (ATIII) levels were markedly reduced in groups 1 and 2, below normal in group 3 and were normal in groups 4 and 5. There was significant urinary loss of ATIII in groups 1 and 2 as well as in group 5. Plasma fibrinogen fluctuations exhibited the expected negative correlations with plasma ATIII. Reptilase time showed significant prolongation in groups 1, 2 and 3, and was near normal in groups 4 and 5. Platelet aggregation in response to arachidonic acid exhibited aggregation followed by disaggregation in groups 1, 2, 4 and 5, and was normal in group 3. Hyperaggregation in response to decreasing doses of ADP was noted in all patient groups as well as controls with no relationship to serum albumin levels. Aggregation responses to collagen and ristocetin were normal. It is concluded that: 1. The fluctuations in ATIII levels in childhood nephrotic syndrome are determined by the response to steroids and not by the renal histology per se. 2. An acquired fibrin polymerization defect (dysfibrinogenaemia) and an abnormality of the prostaglandin pathway of platelet activation, both reversible, are yet other haemostatic abnormalities in childhood nephrosis. 3. The discrepancies in the literature on haemostatic parameters, specially ATIII in childhood nephrosis, would not have arisen if their fluctuation in relation to steroid therapy as well as the renal histological features of nephrotic syndrome had been documented simultaneously.

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Section: Methodsmentioning

confidence: 99%

Haemostatic measurements in childhood nephrotic syndrome

et al. 1991

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“…13,14,29 The similarity in levels of APTT between subjects and controls in this study is in keeping with the reports of Babiker. 21 In contrast, Fiekumo and Shokunbi 28 found prolonged APTT amongst SCA patients. This may be due to the reduced levels of factor Xa in the population they studied.…”

Section: Resultsmentioning

confidence: 92%

“…21,22 However, subjects enrolled into aforementioned studies were of different age group compared to the population being reported in this study. The small sample size in the study by Richardson may also contribute to the discrepancy observed.…”

Section: Resultsmentioning

confidence: 99%

A study of antithrombin 111 in sickle cell anaemia patients in steady state and during vaso-0cclusive crisis in North-Eastern Nigeria

Ladu¹,

Abjah²

2013

AJSIR

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Sickle cell anaemia (SCA) is a genetic disorder which can be complicated by haemolytic, vasoocclusive and thrombotic processes. Antithrombin III (ATIII) is a naturally occurring anticoagulant with anti inflammatory properties. The objective of this study was to determine the level of ATIII in individuals with SCA and to assess its role in vaso-occlusive crisis. This was an observational cross sectional study in which 60 adult HbSS (34 in steady state and 26 in vaso-occlusive crisis) subjects and 60 apparently healthy adults matched for sex and age served as controls. Haemoglobin (Hb) electrophoresis of subjects and controls was determined using Hb electrophoresis. Nine and a half (9.5) milliliters of blood, divided into two aliquots of 4.5mls (in 0.5mls of tri sodium citrate for coagulation studies) and 5mls (in EDTA containing bottle for full blood count) was obtained. Quantitative assessment of antithrombin III by chromogenic assay with Factor Xa was carried out using Diachrom ATIII test kit. Prothrombin time(PT), activated partial thromboplastin time(APTT), haematocrit, total white blood cells (WBC) and platelets count were assessed using standard protocol. SPSS (version 13 for windows) was used for data analysis. A p value of <0.05 was considered significant. The subjects were made up of 33(55%) males and 27(45%) females, with a mean age of 22.52(5.21) years whilst the controls consisted of 34(56.7%) males and 26(43.3%) females with a mean age of 22.85 (4.20). HbS subjects had a significantly lower ATIII levels compared with controls (p=0.009). Levels of ATIII that was found in SCA patients in steady state and in vaso-occlusive crisis did not differ significantly (p=0.468). Haematocrit was significantly lower in HbS than controls (p=0.000), whereas total WBC count (p=0.000), absolute platelet count (p=0.003), and Prothrombin time (0.008) were significantly higher in the HbS subjects. ATIII levels did not differ significantly between steady state and vasoocclusive crisis, suggesting that ATIII does not play an active role in pathogenesis of vasoocclusive crisis.

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“…Blood sam ples were collected with the minimum of venous sta sis into citrate tubes (9 vol blood: 1 vol citrate) on three occasions: (1) I day before starting the drug therapy; (2) on the last day of drug therapy, and (3) 5 days after cessation of therapy. The blood samples were processed as detailed recently by our laboratory [5,6]. Samples for coagulation assays were centri fuged at 4°C at 1,500 g for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Interaction between Nabumetone – a New Non-Steroidal Anti-Inflammatory Drug – and the Haemostatic System ex vivo

Balla

Momen²,

Arfaj³

et al. 1990

Pathophysiol Haemos Thromb

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Twenty-six healthy volunteers were given the non-steroidal anti-inflammatory drug nabumetone (1 g/day p.o.) for 10 days. Platelet aggregation tests in response to adenosine diphosphate, adrenaline, collagen, arachidonic acid, and ristocetin and bleeding time and coagulation screening tests were performed on three occasions: (1) before drug therapy; (2) on the last day of drug therapy, and (3) 5 days after the end of therapy. No significant changes were noted in platelet aggregation, bleeding time, or the coagulation screening tests, except for a significant drop in fibrinogen during therapy and for 1 week after stopping the drug. The lack of any antiplatelet action and minimal effects on the coagulation parameters recommend the drug as a suitable antirheumatic in patients with bleeding disorders. The hypofibrinogenaemic action requires further studies.

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Coagulation Changes in Sickle Cell Disease in Early Childhood

Cited by 14 publications

References 11 publications

Haemostatic measurements in childhood nephrotic syndrome

Haemostatic measurements in childhood nephrotic syndrome

A study of antithrombin 111 in sickle cell anaemia patients in steady state and during vaso-0cclusive crisis in North-Eastern Nigeria

Interaction between Nabumetone – a New Non-Steroidal Anti-Inflammatory Drug – and the Haemostatic System ex vivo

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