Coagulation disorders in dogs with hepatic disease

Prins, Marrit; Schellens, C.J.M.M.; Leeuwen, M.W. van; Rothuizen, J.; Teske, Erik

doi:10.1016/j.tvjl.2009.05.009

Cited by 68 publications

(97 citation statements)

References 38 publications

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“…Increased activity of fibrinolytic system has been associated with DIC [2,42] . Our results were in line with previous studies [2,21,[42][43][44][45] . Some authors [46][47][48] reported that the level of fibrinogen might increase in the first period of DIC due to an inflamatory response; and then this level might decrease because of fibrinolisis.…”

Section: Discussionsupporting

confidence: 94%

“…Some authors [46][47][48] reported that the level of fibrinogen might increase in the first period of DIC due to an inflamatory response; and then this level might decrease because of fibrinolisis. In contrast, other researchers [19,45] reported a significant decrease in fibrinogen level. In this study, a significant increase in fibrinogen level in the dogs with sepsis was observed.…”

Section: Discussioncontrasting

confidence: 56%

See 1 more Smart Citation

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Ok¹,

Er²,

Yıldız³

et al. 2015

Kafkas Univ Vet Fak Derg

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The aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), interferon γ (INF-γ), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1ß, TNF-α, INF-γ, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1ß and TNF-α parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC). Keywords:

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Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 56%

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Ok¹,

Er²,

Yıldız³

et al. 2015

Kafkas Univ Vet Fak Derg

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“…There was a significant decrease (P<0.01) in platelet count in all the dogs of hepatobiliary disorders as compared with healthy control (3.27 ±0.13 x10 5 /µL).Similar findings were reported by Prins et al, (2010) and Tantary et al, (2014), who recorded reduced platelet levels in chronic hepatitis or cirrhosis and hepatobiliary disorders affected dogs. These findings are in agreement with Brovida and Rothuizen (2008), who stated that qualitative and quantitative platelet defects accompany hepatobiliary diseases in dogs.…”

Section: Resultssupporting

confidence: 86%

“…These findings are in agreement with Brovida and Rothuizen (2008), who stated that qualitative and quantitative platelet defects accompany hepatobiliary diseases in dogs. Several mechanisms have been suggested for thrombocytopenia in patients with liver diseases, which include increased platelet sequestration in the spleen as a result of congestive spleenomegaly, reduced production of thrombopoietin by the liver, increased platelet breakdown due to auto antibodies and increased consumption resulting from low grade disseminated intravascular coagulopathy (Prins et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Coagulation Profile in Hepatobiliary Disorders Affected Dogs

Lakshmi¹,

Padmaja²,

Nagaraj³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…Prins et al suggested that these coagulopathies are the result of a decreased production rather than an increased consumption of clotting factors (Prins et al 2010). In all our 10 dogs with coagulopathy at baseline, coagulation parameters returned to normal after 1 week of prednisolone treatment.…”

Section: Discussionmentioning

confidence: 50%

A retrospective study of oral prednisolone treatment in canine chronic hepatitis

Favier

Poldervaart

Ingh³

et al. 2013

Veterinary Quarterly

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Background: Only one study reports prednisone to prolong survival in dogs with chronic hepatitis irrespective of the causative agent. The aim of this retrospective study was to investigate the effects of prednisolone treatment on survival, clinicopathological variables, and histological grade and stage of idiopathic chronic hepatitis in 36 dogs. Animals and methods: Medical records were reviewed of 36 prednisolone-treated dogs (median age: 8.6 years; range: 2.0-14.6 years) with chronic hepatitis not associated with primary copper accumulation. Clinicopathological results were analyzed pair-wise for 20 dogs, before and after oral prednisolone administration (1 mg/kg BW/day). Dogs were treated for at least 6 weeks, and for an additional 6 weeks if hepatitis was still present at rebiopsy. Follow-up data pertaining to clinical outcome and survival time (Kaplan-Meier estimate procedure) were analyzed. Results: At the follow-up, 11 dogs were in complete remission, 8 dogs had recurrent clinical signs, and 17 dogs had residual disease. Despite treatment, 20 dogs died of hepatitis-related causes. Dogs without cirrhosis survived significantly longer than dogs with cirrhosis. Prednisolone treatment normalized coagulopathies associated with chronic idiopathic hepatitis within one week in all 10 dogs that had coagulopathies at initial diagnosis. Conclusions: Our findings suggest that prednisolone has, in part, beneficial effects on hepatic inflammation and that it may, at least in some cases, limit the progression of fibrosis, which emphasizes the importance of early diagnosis and treatment. We did not see any benefit of prednisolone treatment for dogs with cirrhosis. We could document a highly favorable effect of prednisolone treatment on the coagulopathy associated with canine chronic idiopathic hepatitis.

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Coagulation disorders in dogs with hepatic disease

Cited by 68 publications

References 38 publications

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Coagulation Profile in Hepatobiliary Disorders Affected Dogs

A retrospective study of oral prednisolone treatment in canine chronic hepatitis

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