Coagulation dynamics and platelet functions in obstructive jaundiced patients

Abstract

Even though there is a general assumption about the increased bleeding tendency in obstructive jaundiced patients, we could not demonstrate reduced clotting activity by measuring with either PFA or TEG. On the contrary we observed tendency for hypercoagulation independent of increased prothrombin times. The most probable cause of this effect is the increased activity of fibrin polymers on platelet membrane.

Association of serum neuron‐specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large‐artery atherosclerotic strokes

“…26 Kawle et al found that serum levels of NSE were an independent predictor of the outcome in IS patients. [29][30][31] Thus, high levels of NSE and bilirubin indicate severe brain injury and a poor prognosis, while patients with low-NSE concentrations might have a better neurological recovery. 28 Bilirubin is an important antioxidant.…”

Hemostasis and Thrombosis in Major Liver Resection

“…Vitamin K deficiency can cause prolongation of prothrombin time (PT) and activated partial thromboplastin time (aPTT), but other screening tests typically remain normal. 9 Even so, a study by Çakır et al 11 evaluated standard measures of coagulation as well as thromboelastography and platelet function using PFA-100 before and after relief of obstruction in 23 patients with obstructive jaundice mainly due to underlying malignancy. Although PT was prolonged in 56% of patients, this was not associated with an increase in bleeding risk as assessed by these functional assays.…”

Synthesis and Biocompatibility Studies of New Iminodiacetic Acid Derivatives

“…For instance, hypercoagulation has been detected among patients with obstructive jaundice. The authors reported a correlation between strength, elasticity and coagulation indices of the clot and increased concentrations of direct bilirubin [ 17 ]. Other studies also report a significant positive correlation between high bilirubin concentration and prolonged APTT and PT times, basic markers of coagulation efficacy [ 18 , 19 , 20 ].…”