Coagulation factor VII gene polymorphisms and cardiovascular diseases in Iranian population

Ramzi, Mani; Cohan, Nader; Yavarian, Majid; Jahromi, Mehdi Roshannia; Beigi, Mohammadali Babaie; Fakhraee, Farzaneh; Masoomi, Rahim

doi:10.1016/j.jicc.2012.12.004

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…They showed that there was no significant difference about these polymorphisms between patients and controls. Likewise, Ramzi et al [20] reported a similar result in their study. They tried to identify the role of factor VII-401 G/T and HVR4 polymorphisms in CAD.…”

Section: Discussionsupporting

confidence: 73%

“…It was reported that -323rd nucleotide polymorphism in promoter has no biological activity [9]. Effects of the -401 G/T and -402 G/A polymorphisms over CAD and cerebrovascular diseasewere investigated in limited number of studies [17][18][19][20]. Kang et al [17] reported that activated factor VII (FVIIa) level and factor VII coagulant activity (FVIIc) were higher in the AMI patients.…”

Section: Discussionmentioning

confidence: 99%

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Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population

Dönmez

Koca

İçen

et al. 2019

The European Research Journal

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Objectives: Factor VII has a crucial role in the extrinsic coagulation pathway and initiates the thrombus formation. Some studies showed that high plasma factor VII level was related to increased acute myocardial infarction (AMI) risk. But, some studies were reported opposite findings. Some polymorphisms can change the factor VII level. There is limited information about factor VII polymorphisms in southern Turkey population. Our aim was to determine the frequencies of Factor VII-401 and-402 polymorphisms and their relation to AMI in southern Turkey area. Methods: We enrolled 83 patients with AMI and 71 healthy subjects. Routine laboratory tests and factor VII-401 and-402 polymorphisms were determined from blood samples. Factor VII-401 and-402 polymorphisms were analyzed by LightCycler device using Real-Time PCR technique. Results: Family history of coronary artery disease and smoking frequencies were higher in patients group (p < 0.001 and p = 0.013, respectively). Patients had higher LDL cholesterol (p = 0.011) level, and lower HDL cholesterol (p = 0.025) level compared to healthy subjects. Factor VII-401 and-402 polymorphism genotypes were not significantly different in both groups. Also allele frequencies were similar in both groups. Conclusion: Factor VII-401 and-402 polymorphisms do not seem to increase AMI risk in southern Turkey.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population

Dönmez

Koca

İçen

et al. 2019

The European Research Journal

View full text Add to dashboard Cite

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Analysis of the contribution of polymorphisms of hemostasis system genes and folate cycle genes to the genetic presposition to the development of thrombosis in patients with Ph-negative myeloproliferative neoplasia in the Republic of Uzbekistan

Berger,

Assesorova,

Makhmudova

2024

МиЭ

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Thrombotic complications often complicate the course of the underlying disease in patients with chronic myeloproliferative neoplasia. However, a thromboembolic condition is not observed in all patients.The aim of the study was to assess the carriage frequency of polymorphic genes of the blood coagulation system and folate metabolism genes and the contribution of genetic variants to the development of thrombosis in patients with chronic Ph-negative myeloproliferative neoplasia (CMPN).Materials and methods. Molecular genetic testing for the presence of genetic variants with an assessment of their frequency of occurrence and allelic load was carried out in 142 patients with CMPN. We studied polymorphisms of the folate cycle genes – A2756G (Asp919Gly) of the MTR gene, C677T (Ala22Val) of the MTHFR gene, A66G (ILe22Met) of the MTRR gene (rs1801394), as well as mutations of the genes of blood coagulation factors – G(455)A of the FGB gene, G20210A of the F2 gene, G10976A (Arg353Gln) of the F7 gene, G1691A (Arg506Gln) of the F5 gene. The study was carried out using real-time polymerase chain reaction (PCR); The biological material for the test was whole blood.Results and discussion. The study showed that only 6 out of 50 (12%) patients with thrombotic complications had no changes in the genes studied, while 88% of patients had one or another genotypic variant, which may indicate a high probability of involvement of a hereditary genetic factor in the development of hypercoagulability and thrombotic complications in patients with chronic MPN.Conclusions. A comprehensive study of the role, interaction and operating conditions of genes that control blood coagulation processes in patients with Ph-negative chronic MPN will make it possible to understand the causes of hemostatic system disorders and develop effective measures to prevent thrombotic complications in this category of patients.

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Coagulation factor VII gene polymorphisms and cardiovascular diseases in Iranian population

Cited by 2 publications

References 16 publications

Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population

Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population

Analysis of the contribution of polymorphisms of hemostasis system genes and folate cycle genes to the genetic presposition to the development of thrombosis in patients with Ph-negative myeloproliferative neoplasia in the Republic of Uzbekistan

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