Coagulation Studies, Factor V Leiden, and Anticardiolipin Antibodies in 40 Cases of Cerebral Venous Thrombosis

Abstract

Although present in a number of CVT cases, acquired (anticardiolipin) or congenital varieties of thrombophilia (factor V Leiden being the most frequent) are almost invariably associated with other predisposing factors. This suggests that (1) these abnormalities should be looked for in patients with CVT, whether a cause is found or not, and (2) their presence should not deter the search for other potential causes. The detection of such abnormalities has major practical consequences on the long-term management of patients to prevent further thrombotic episodes.

Factor V Leiden Mutation Is a Risk Factor for Cerebral Venous Thrombosis

“…This leads to a relative risk for FVL of 2.55. Our results are in the range of previously published, smaller series (ie, 10% to 25%), [21][22][23][24][25][26] and confirm FVL as a risk factor for CVT.…”

“…28 In only 3 of the previously discussed patients with CVT and FVL, a history of previous venous thrombosis had been reported. 12,21 Quite contrary, in our cohort, patients with the FVL mutation had antecedent DVT significantly more frequently (62.5%) than FVL-negative patients (PϽ0.005).…”

“…19 Also in 1997, another 4 patients with sinus thrombosis after dural puncture were described with either the FVL mutation or APC resistance. 20 Furthermore, 6 studies based on 12 to 40 patients with CVT found prevalences of FVL ranging from 10% to 25% [21][22][23][24][25][26] (Table 1). All patients with CVT described in these reports were heterozygous for the FVL mutation.…”

Trombose de seio dural: relato de caso

“…ceptivos orais, traumatismo cranioencefálico, lesão d i reta dos seios ou veia jugular, procedimentos neuro c i r ú rgicos, punção lombar e de várias outras circ u n s t â n c i a s 1 , 2 , 8 , 9 . Condições pro t rombóticas here d i t á-rias, como fator V de Leiden, deficiência das pro t e í n a s C e S e antitrombina III contribuem com 10% a 15% dos casos de TSD 10,11 . O tratamento da TSD visa a recanalizar o seio tro mbosado, o que pode ser obtido com terapia anticoagulante ou trombolítica.…”

“…Condições pro t rombóticas here d i t á-rias, como fator V de Leiden, deficiência das pro t e í n a s C e S e antitrombina III contribuem com 10% a 15% dos casos de TSD 10,11 . O tratamento da TSD visa a recanalizar o seio tro mbosado, o que pode ser obtido com terapia anticoagulante ou trombolítica.…”