Coating rice with mulberry leaves rich in deoxynojirimycin ameliorates hyperglycemia and dyslipidemia in C57BL/KsJdb/dbmice

Abstract

BACKGROUND/OBJECTIVESMulberry leaf (ML) has been shown to have an inhibitory effect on α-glucosidase, and suppresses postprandial hyperglycemia, which may be related to its deoxynojirimycin (DNJ) content. This study was conducted to investigate the hypoglycemic and dyslipidemic effects of rice coated with ML rich in DNJ in a type 2 diabetes mouse model.MATERIALS/METHODSThe mice were divided into four groups (n = 8 each): non-diabetic normal control (NC); diabetic control (DM-C), fed with 10% polished rice powder (DM-R); and fed with 10% polished rice powder coated with DNJ-rich ML (DM-DNJR).RESULTSSupplementation with DNJR for six weeks decreased levels of fasting blood glucose, plasma insulin, triglyceride, total cholesterol, and blood glycosylated hemoglobin; conversely, levels of glucagon-like peptide-1 and high-density lipoprotein-cholesterol showed an increase in the same treatment. In addition, weights of mesenteric, epididymal, and total adipose tissues decreased with DNJR supplementation, when compared with diabetic control db/db mice, while maltase, lactase, and sucrase activity in the small intestine were inhibited. The anti-diabetic effects were marginally greater in the DM-DNJR group than in the DM-R group.CONCLUSIONSThese results suggest that rice coated with ML rich in DNJ can reduce hyperglycemia and hyperlipidemia in db/db mice, and may prove useful for individuals with diabetes.

Mulberry extract as an ecofriendly anticoccidial agent: in vitro and in vivo application

“…Jejunal infection with E. papillata in mice results in oxidative damage and serious local and systemic inflammatory responses (Dkhil et al, 2013). M. nigra is a plant that possesses anti-inflammatory (Yildirim et al, 2019), antioxidant (Lee et al, 2018), and antiparasitic (Ercisli & Orhan, 2007) activity. The leaves of black mulberry contain flavonoids, ascorbic, and phenolics (Iqbal et al, 2012;Chen et al, 2016).…”

Chemical Constituents, Antioxidant, and α-Glucosidase Inhibitory Activities of Different Fermented Gynostemma Pentaphyllum Leaves and Untargeted Metabolomic Measurement of the Metabolite Variation

“…Fermentation has been found to significantly increase the TPC and TFC in common buckwheat and Tartary buckwheat. However, with prolonged fermentation, the rutin content in fermented common buckwheat slightly reduces, which leads to a further reduction in the TFC [ 27 ]. In general, for FGPL, the TPC and TFC could increase to different degrees after a short-term fermentation, but they decreased throughout the fermentation.…”

Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway

“…22 It is known for its antidiabetic effects that are mediated by inhibiting the activity of α-glucosidase and regulating the expression of certain mRNAs and proteins. 23 Recently, 1-deoxynojirimycin has been the focus of attention because of its therapeutic effects against diabetes 24 and hyperlipidemia 25 and its cardioprotective 26 and anticancer effects. 27 Cancer cells are well known to use glycolysis as a source of energy and require more glucose (energy) than normal cells.…”