Coatings Based on Two-Dimensionally Ordered Linear Chain Carbon for Protection of Titanium Implants from Microbial Colonization

Tapalski, D. V.; Тапальский, Д. В.; Николаев, Н. С.; Ovsyankin, A. V.; Овсянкин, А В; Kochakov, V. D.; Golovina, Elena A.; Матвеенков, М. В.; Сухорукова, М В; Козлов, Р С

doi:10.21823/2311-2905-2019-25-2-111-120

Cited by 5 publications

(1 citation statement)

References 25 publications

(26 reference statements)

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“…В лабораторных условиях была доказана способность такого покрытия к полному предотвращению формирования микробных биопленок антибиотикорезистентными штаммами S. aureus и P. aeruginosa с ранее выявленной высокой способностью к пленкообразованию. Покрытия были сформированы методом ионно-стимулированной конденсации углерода в вакууме на поверхностях титановых пластин [17].…”

Section: Treatment Of Periprosthetic Infection With Silver-doped Implunclassified

Treatment of Periprosthetic Infection with Silver-Doped Implants Based on Two-Dimensionally Ordered Linear Chain Carbon

Николаев

Lyubimova²,

Любимова³

et al. 2019

Traumatology and Orthopedics of Russia

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Relevance. Formation of pan-resistance microorganisms, microbial biofilms on implants and recurrent infection rate stimulate the search for optimal prosthesis materials for treatment of periprosthetic infection (PJI). Purpose of the study — to compare the efficiency of two stage PJI treatment with simultaneous implantation of a spacer in combination with implants with silver-doped coatings based on two-dimensionally ordered linear chain carbon (TDOLCC+Ag) during the first stage and the conventional revision with a spacer only. Materials and methods. The study included 72 patients with PJI of the knee (n = 42) and hip (n = 30) joints. Control group (conventional revision) consisted of 35 patients and the main group (TDOLCC+Ag coated implant incorporated in a spacer) — 37 patients. Mean age of the patients was 61 years. Temporary components were replaced by the final components during revision at the second stage. Evaluation methods: clinical, X-ray, laboratory, microbiological and follow up history. Results. Inflammation markers and synovial fluid cytosis in the groups at the first revision stage featured equal high base values. During the second stage leucocyte count and cytosis reached normal values, ESR decreased twofold in both groups, CRP decreased five times in the main group. Throat and nasal swabs demonstrated growth of Staphylococcus aureus at 24,3-32,4% in both groups. The leading inducer of PJI was staphylococcal flora with MRSA share of 7,1% and MRSE — from 62,5 to 66,7%. End-points of evaluating treatment outcomes were revision spacer implantation at the second stage of sanation and recurrent PJI. Control group featured implantation of more revision spacers (5) as compared to the main group (1) after the treatment. Two recurrent PJIs were reported for the control group in 11 months while no recurrent infection was reported for the main group. Conclusion. The study demonstrated statistically significant improvement in the outcomes of PJI treatment by spacers with implants coated by TDOLCC+Ag as compared to the conventional treatment option.

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Section: Treatment Of Periprosthetic Infection With Silver-doped Implunclassified

Treatment of Periprosthetic Infection with Silver-Doped Implants Based on Two-Dimensionally Ordered Linear Chain Carbon

Николаев

Lyubimova²,

Любимова³

et al. 2019

Traumatology and Orthopedics of Russia

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Effect of Heating Procedure and Annealing Temperature on Transmission Spectra of sp1-Carbon Films Synthesized by the Ion-Plasma Method

et al. 2022

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Treating Periprosthetic Joint Infection With Silver-Impregnated Carbon-Coated Spacers: Mid-Term Outcomes

Malyuchenko,

Nikolaev,

Yakovlev

et al. 2023

Traumatology and Orthopedics of Russia

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The aim of the study to evaluate the antibacterial activity and biological compatibility of alloy coatings based on two-dimensionally ordered linear chain carbon (TDOLCC) and medium-term results of treatment of periprosthetic infection with their use. Materials and Methods. Coatings based on TDOLCC were synthesized using alloying additions like nitrogen (TDOLCC+N) and silver (TDOLCC+Ag) on the surfaces of titanium plates and polystyrene plates by the ion-stimulated carbon condensation in a vacuum. The authors examined the superficial bactericidal activity of the coatings and its resistance to mechanical effects. The rate of formation of microbial biofilms by clinical isolates with multiple and extreme resistance to antibiotics was assessed by staining the samples with a solution of crystal violet. The cytotoxic effect of the coatings was evaluated in relation to the primary culture of fibroblasts and keratinocyte cells of the HaCaT line. Results. The authors observed pronounced superficial bactericidal effect of TDOLCC+Ag coating in respect of microorganisms of several taxonomic groups independently of their resistance to antibacterial drugs. TDOLCC+Ag coating proved capable to completely prevent microbial biofilm formation by antibiotic resistant clinical isolates of S. aureus and P. aeruginosa. Silvercontaining coating demonstrated mechanical resistance and preservation of close to baseline level of superficial bactericidal activity even after lengthy abrasion treatment. TDOLCC based coatings did not cause any cytotoxic effects. Structure of monolayers formed in cavities coated by TDOLCC+N and TDOLCC+Ag was indistinguishable from the monolayers in cavities of control plates. Conclusions. The high anti-film activity of DU LCC+Ag coatings was proved in experiment and clinical practice at the follow-up stage. The use of a spacer with a test coating allows you to quickly eliminate the inflammatory process, significantly reduce the number of relapses of PJI in cases of CS and TB infections, and reduce the number of hospital stay days. Evaluation of the mid-term results of PJI treatment gives grounds to predict active protection of the implant surface from colonization by microorganisms and the formation of microbial biofilms, which, together with drug antibiotic prophylaxis, provides a good therapeutic and prophylactic effect on the recurrence of periprosthetic infection.

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Coatings Based on Two-Dimensionally Ordered Linear Chain Carbon for Protection of Titanium Implants from Microbial Colonization

Cited by 5 publications

References 25 publications

Treatment of Periprosthetic Infection with Silver-Doped Implants Based on Two-Dimensionally Ordered Linear Chain Carbon

Treatment of Periprosthetic Infection with Silver-Doped Implants Based on Two-Dimensionally Ordered Linear Chain Carbon

Effect of Heating Procedure and Annealing Temperature on Transmission Spectra of sp1-Carbon Films Synthesized by the Ion-Plasma Method

Treating Periprosthetic Joint Infection With Silver-Impregnated Carbon-Coated Spacers: Mid-Term Outcomes

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