Cobalamin deficiency presenting as obsessive compulsive disorder: case report

Sharma, Vivek R.; Biswas, Devdutta

doi:10.1016/j.genhosppsych.2011.11.006

Cited by 11 publications

(8 citation statements)

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“…This suggests that obsessive–compulsive symptoms can be a marker for vitamin B12 deficiency and predicts more well-known symptoms of it. Sharma and Biswas reported a case of a middle-aged male patient presenting with OCD, low levels of serum vitamin B12, and a positive family history of vitamin B12 deficiency who responded well to methylcobalamin replacement 18. Based on this, they suggested a possible etiological role of vitamin B12 in OCD 18.…”

Section: Discussionmentioning

confidence: 97%

“…Sharma and Biswas reported a case of a middle-aged male patient presenting with OCD, low levels of serum vitamin B12, and a positive family history of vitamin B12 deficiency who responded well to methylcobalamin replacement 18. Based on this, they suggested a possible etiological role of vitamin B12 in OCD 18. Atmaca et al reported that serum folate values were significantly lower in OCD patients than controls, while homocysteine concentrations were higher in patients compared to controls 16…”

Section: Discussionmentioning

confidence: 99%

“…Observations on the antidepressant effects of folate supplementation may support the importance of these nutrients in psychopathology 13,14. Although comorbidity of depressive and anxiety disorders is common, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders – especially in obsessive–compulsive disorder (OCD) 15–18. OCD shows a prevalence of 1%–3% globally, and it follows a chronic course with increased rates of comorbidity.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder

Türksoy¹,

Bilici

Yalçıner³

et al. 2014

NDT

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It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline, and dementia. Current literature shows that some psychiatric disorders, mainly affective and psychotic ones, can be related to the levels of vitamin B12, folate, and homocysteine. These results can be explained by the importance of vitamin B12, folate, and homocysteine in carbon transfer metabolism (methylation), which is required for the production of serotonin as well as for other monoamine neurotransmitters and catecholamines. Earlier studies focused on the relationship between folate deficiency, hyperhomocysteinemia, and depressive disorders. Although depressive and anxiety disorders show a common comorbidity pattern, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders – especially in obsessive–compulsive disorder (OCD). This study aimed to measure the levels of vitamin B12, folate, and homocysteine specifically in order to see if eventual alterations have an etiopathogenetic significance on patients with OCD. Serum vitamin B12, folate, and homocysteine concentrations were measured in 35 patients with OCD and 22 controls. In addition, the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Yale–Brown Obsessive Compulsive Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety were conducted for each patient. It was found that vitamin B12 levels were decreased and homocysteine levels were increased in some OCD patients. Homocysteine levels were positively correlated with Yale–Brown compulsion and Yale–Brown total scores. In conclusion, findings of this study suggest that some OCD patients might have vitamin B12 deficiency and higher homocysteine levels.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder

Türksoy¹,

Bilici

Yalçıner³

et al. 2014

NDT

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“…Based on reports that different patterns of exploratory activity can be considered reliable indicators of anxiety (48)(49)(50), we can also compare our results with clinical trials that analyse the connection between impaired one-carbon metabolism and anxiety disorders, such as obsessive-compulsive disorder (23,24,26).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it has been reported that patients with depression had lower serum levels of folate and vitamin B 12 (21,22). Additionally, numerous anxiety disorders are related to impaired one-carbon metabolism (23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Methionine-Enriched and Vitamins (Folate, Pyridoxine and Cobalamine)-Deficient Diet on Exploratory Activity in Rats - A Brief Report

Mijailović

Selaković

Joksimović

et al. 2017

Serbian Journal of Experimental and Clinical Research

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Th e aim of this study was to evaluate the impact of increased homocysteine levels induced by methionine nutritional overload (twice as standard) and defi ciency of the vitamins folate, pyridoxine and cobalamine, which plays an important role in homocysteine metabolism in anxiety-related behaviour, expressed by means of exploratory activity in rats. Twenty-three male Wistar albino rats (4 weeks old, 100±15 g body weight) were divided into three groups: control (n=8), methionine-enriched (Meth+, 7.7 g of methionine/kg chow, n=7) and methionine-enriched vitamin-defi cient (Meth+Vit-, 7.7 g of methionine/kg chow, defi cient in folate, pyridoxine and cobalamine -0.08, 0.01 and 0.01 mg/kg, n=8). All animals had free access to food and water for 30 days. Behavioural testing was performed using the elevated plus maze (EPM) test. Standard parameters for vertical exploratory activity, the number of rearings and the number of head-dippings, as well as the total exploratory activity (summarizing overall exploratory activity in the EPM) were signifi cantly reduced following 30 days of methionine nutritional overload (p<0.05, p<0.05 and p<0.01, respectively). A methionine-enriched diet coupled with a reduction in some B vitamins resulted in a more pronounced decline in exploratory drive observed in the EPM test compared to the control (p<0.01). Th e decline in total exploratory activity associated with vitamin defi ciency was signifi cant compared to the Meth+ group (p<0.05). Th e results of this study highlight the important role of homocysteine in the modulation of exploratory activity in rats. Decreased exploratory drive induced by both a methionine-enriched and vitamin-defi cient diet could be attributed to an anxiogenic eff ect of hyperhomocysteinemia.

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Nutrition and Psychiatric Disorders: Focus on Schizophrenia

Mansour

2022

Nutritional Neurosciences

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Cobalamin deficiency presenting as obsessive compulsive disorder: case report

Cited by 11 publications

References 9 publications

Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder

Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder

The Effects of Methionine-Enriched and Vitamins (Folate, Pyridoxine and Cobalamine)-Deficient Diet on Exploratory Activity in Rats - A Brief Report

Nutrition and Psychiatric Disorders: Focus on Schizophrenia

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Cobalamin deficiency presenting as obsessive compulsive disorder: case report

Cited by 11 publications

References 9 publications

Vitamin B12, folate, and homocysteine levels in patients with obsessive&ndash;compulsive disorder

Vitamin B12, folate, and homocysteine levels in patients with obsessive&ndash;compulsive disorder

The Effects of Methionine-Enriched and Vitamins (Folate, Pyridoxine and Cobalamine)-Deficient Diet on Exploratory Activity in Rats - A Brief Report

Nutrition and Psychiatric Disorders: Focus on Schizophrenia

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Product

Resources

About

Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder

Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder