Cobalamin, Microbiota and Epigenetics

Jory, Joan

doi:10.1007/978-3-319-55530-0_47

Cited by 2 publications

(2 citation statements)

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“…Cobalamin (vitamin B12) affects methylation reactions by serving as a cofactor for the enzyme methionine synthase (MS), which catalyzes the conversion of homocysteine (hCYS) to methionine ( Figure 1 ). Small intestinal bacterial overgrowth affects vitamin B12 host availability by converting cobalamin to host-inaccessible cobalamin corrinoids (Jory, 2019 ). The method by which morphine-induced expansion of pathogenic bacteria and decreased abundance of Bifidobacterium and L actobacillus affects the levels of the B-complex group of vitamins has to be determined to fully understand the role of morphine-induced expansion of dysbiotic bacteria in DNA modulation and histone methylation.…”

Section: Gut Microbial Metabolism and Opioid-induced Alterations In D...mentioning

confidence: 99%

The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome

Kolli,

Roy

2023

Front. Microbiol.

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The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also implicated in the development of tolerance. Recently, it has been shown that opioid use results in microbial dysbiosis, leading to gut barrier disruption, which drives systemic inflammation, impacting the perception of pain, the development of analgesic tolerance, and behavioral outcomes. In this review, we highlight the potential role of microbiota and microbial metabolites in mediating the epigenetic modifications induced by opioid use.

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Section: Gut Microbial Metabolism and Opioid-induced Alterations In D...mentioning

confidence: 99%

The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome

Kolli,

Roy

2023

Front. Microbiol.

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“…1 ), which is required for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis and acts as an intracellular superoxide scavenger. 3…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

Ngoepe

Clayton

2021

Pharmaceutical Fronts

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Medicinal inorganic chemistry involving the utilization of metal-based compounds as therapeutics has become a field showing distinct promise. DNA and RNA are ideal drug targets for therapeutic intervention in the case of various diseases, such as cancer and microbial infection. Metals play a vital role in medicine, with at least 10 metals known to be essential for human life and a further 46 nonessential metals having been involved in drug therapies and diagnosis. These metal-based complexes interact with DNA in various ways, and are often delivered as prodrugs which undergo activation in vivo. Metal complexes cause DNA crosslinking, leading to the inhibition of DNA synthesis and repair. In this review, the various interactions of metal complexes with DNA nucleic acids, as well as the underlying mechanism of action, were highlighted. Furthermore, we also discussed various tools used to investigate the interaction between metal complexes and the DNA. The tools included in vitro techniques such as spectroscopy and electrophoresis, and in silico studies such as protein docking and density-functional theory that are highlighted for preclinical development.

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Cobalamin, Microbiota and Epigenetics

Cited by 2 publications

References 83 publications

The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome

The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome

Metal Complexes as DNA Synthesis and/or Repair Inhibitors: Anticancer and Antimicrobial Agents

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