Cobalt Ferrite Nanoparticles as Multifunctional Cross-Linkers in PAAm Ferrohydrogels

Messing, Renate; Frickel, Natalia; Belkoura, L.; Strey, R.; Rahn, Helene; Odenbach, Stefan; Schmidt, Annette

doi:10.1021/ma102708b

Cited by 134 publications

(159 citation statements)

References 29 publications

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“…9 Permanent linkage to the network also prevents nanoparticles from diffusing out of the gel, thereby limiting the loss of responsive materials and the potential toxic effects in biomedical applications. 62 These covalent NP-gels provide a system with better-defined coupling between nanoparticles and polymer matrix and thus open a way for better understanding of material structure-property relationship and subsequent modification for improved drug delivery properties.…”

Section: Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

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Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

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Section: Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

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“…Messing et al [9] reported on the transfer of CoFe 2 O 4 nanoparticles from nonpolar to aqueous media, while at the same time, the surface was functionalized so that the nanoparticles functioned as cross-linkers in a poly(acryl amide) gel. Establishing the function of the nanoparticles as cross-linkers was demonstrated by leakage experiments and by dissolution of the particles upon which the hydrogel fully disintegrated.…”

Section: Introductionmentioning

confidence: 99%

Frequency-Dependent Magnetic Susceptibility of Magnetite and Cobalt Ferrite Nanoparticles Embedded in PAA Hydrogel

Berkum

Dee

Philipse

et al. 2013

IJMS

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Chemically responsive hydrogels with embedded magnetic nanoparticles are of interest for biosensors that magnetically detect chemical changes. A crucial point is the irreversible linkage of nanoparticles to the hydrogel network, preventing loss of nanoparticles upon repeated swelling and shrinking of the gel. Here, acrylic acid monomers are adsorbed onto ferrite nanoparticles, which subsequently participate in polymerization during synthesis of poly(acrylic acid)-based hydrogels (PAA). To demonstrate the fixation of the nanoparticles to the polymer, our original approach is to measure low-field AC magnetic susceptibility spectra in the 0.1 Hz to 1 MHz range. In the hydrogel, the magnetization dynamics of small iron oxide nanoparticles are comparable to those of the particles dispersed in a liquid, due to fast Néel relaxation inside the particles; this renders the ferrogel useful for chemical sensing at frequencies of several kHz. However, ferrogels holding thermally blocked iron oxide or cobalt ferrite nanoparticles show significant decrease of the magnetic susceptibility resulting from a frozen magnetic structure. This confirms that the nanoparticles are unable to rotate thermally inside the hydrogel, in agreement with their irreversible fixation to the polymer network.

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“…In reality, it can for example be tuned during synthesis by the way of embedding the magnetic particles in the polymer matrix. For instance, rotations of elongated magnetic particles [38] are hindered when compared to spheres, and magnetic particles that are actually part of the network due to chemical surface functionalization [6,7] experience permanent restoring torques under reorientation [8].…”

Section: Impact Of Orientational Memorymentioning

confidence: 99%

Tunable dynamic response of magnetic gels: Impact of structural properties and magnetic fields

et al. 2014

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Ferrogels and magnetic elastomers feature mechanical properties that can be reversibly tuned from outside through magnetic fields. Here we concentrate on the question how their dynamic response can be adjusted. The influence of three factors on the dynamic behavior is demonstrated using appropriate minimal models: first, the orientational memory imprinted into one class of the materials during their synthesis; second, the structural arrangement of the magnetic particles in the materials; and third, the strength of an external magnetic field. To illustrate the latter point, structural data are extracted from a real experimental sample and analyzed. Understanding how internal structural properties and external influences impact the dominant dynamical properties helps to design materials that optimize the requested behavior.

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Cobalt Ferrite Nanoparticles as Multifunctional Cross-Linkers in PAAm Ferrohydrogels

Cited by 134 publications

References 29 publications

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Frequency-Dependent Magnetic Susceptibility of Magnetite and Cobalt Ferrite Nanoparticles Embedded in PAA Hydrogel

Tunable dynamic response of magnetic gels: Impact of structural properties and magnetic fields

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