2022
DOI: 10.1093/pnasnexus/pgac191
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Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

Abstract: Increased oxidative stress underlies a variety of diseases, including diabetes. Here we show that the cobalamin/vitamin B12 analog cobinamide is a strong and multi-faceted antioxidant, neutralizing superoxide, hydrogen peroxide, and peroxynitrite, with apparent rate constants of 1.9 × 108, 3.7 × 104, and 6.3 × 106 M−1 s−1, respectively for cobinamide with the cobalt in the + 2 oxidation state. Cobinamide with the cobalt in the + 3 oxidation state yielded apparent rate constants of 1.1 × 108 and 8.0 × 102 M−1 s… Show more

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Cited by 7 publications
(5 citation statements)
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“…The cobinamide-treated mice appeared normal and gained weight just as untreated mice, similar to our previous results in Prkg1 R177Q/+ mice and diabetic mice. 35 , 36 The only laboratory abnormality in the cobinamide-treated mice was an increase in peripheral blood monocytes, reaching significance in the mutant mice; the clinical implications of this are unclear, particularly because we found no increase in monocytic infiltration into the aorta. In rats, we found cobinamide had a serum half-life of ∼11 hours after oral administration.…”
Section: Discussionmentioning
confidence: 67%
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“…The cobinamide-treated mice appeared normal and gained weight just as untreated mice, similar to our previous results in Prkg1 R177Q/+ mice and diabetic mice. 35 , 36 The only laboratory abnormality in the cobinamide-treated mice was an increase in peripheral blood monocytes, reaching significance in the mutant mice; the clinical implications of this are unclear, particularly because we found no increase in monocytic infiltration into the aorta. In rats, we found cobinamide had a serum half-life of ∼11 hours after oral administration.…”
Section: Discussionmentioning
confidence: 67%
“… 47 This is consistent with our previous results in mice treated with similar cobinamide concentrations in the drinking water. 36 …”
Section: Discussionmentioning
confidence: 99%
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“…Since rotenone can increase oxidative stress in cells ( Fig. 1 B), it seems possible that an agent which neutralizes reactive oxygen species could be useful in treating rotenone poisoning [ 4 , 7 , [32] , [33] , [34] ]. Testing of such agents in animal models would appear indicated.…”
Section: Discussionmentioning
confidence: 99%