Cocaine- and amphetamine-regulated transcript peptide increases spatial learning and memory in rats

Upadhya, Manoj A.; Nakhate, Kartik T.; Kokare, Dadasaheb M.; Singru, Praful S.; Subhedar, Nishikant K.

doi:10.1016/j.lfs.2010.12.008

Cited by 47 publications

(26 citation statements)

References 66 publications

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“…Adcyap1, or Pacap, has been shown to facilitate learning (Telegdy and Kokavszky 2000), and Pacap mutants display impaired hippocampal LTP (Matsuyama et al 2003). Finally, Cart promotes spatial learning and memory in rats (Upadhya et al 2011). Although the ensemble of these observations is in line with our findings, and further supports that neuropeptides have a crucial role in modulating neuronal function, direct demonstrations of enhanced neuronal specificity (in tuning or RF profile) during up-regulation of specific neuropeptides are currently lacking.…”

supporting

confidence: 86%

Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex

et al. 2014

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Modulation of cortical network connectivity is crucial for an adaptive response to experience. In the rat barrel cortex, longterm sensory stimulation induces cortical network modifications and neuronal response changes of which the molecular basis is unknown. Here, we show that long-term somatosensory stimulation by enriched environment up-regulates cortical expression of neuropeptide mRNAs and down-regulates immediate-early gene (IEG) mRNAs specifically in the barrel cortex, and not in other brain regions. The present data suggest a central role of neuropeptides in the fine-tuning of sensory cortical circuits by long-term experience.

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confidence: 86%

Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex

et al. 2014

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“…At least for the 7 days UCS group, the crf increase observed here may be related to learning and memory (Radulovic et al, 1999) as there was a significant improvement in avoidance learning on day 3 compared with day 2. In support of this, expression levels of htr1ab (Ögren et al, 2008) and cart4 (Upadhya et al, 2011;Yermolaieva et al, 2001), shown to be involved in learning and memory as well, also significantly increased in the 7 days UCS group. This hypothesis is strengthened by the loading of these genes (along with crf-bp, which probably follows the expression pattern of crf) onto the same component in the PCA.…”

Section: Research Articlementioning

confidence: 62%

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Manuel

Gorissen

Zethof

et al. 2014

Journal of Experimental Biology

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Zebrafish (Danio rerio Hamilton) are increasingly used as a model to study the effects of chronic stress on brain and behaviour. In rodents, unpredictable chronic stress (UCS) has a stronger effect on physiology and behaviour during the active phase than during the resting phase. Here, we applied UCS during the daytime (active phase) for 7 and 14 days or during the night-time (resting phase) for 7 nights in an in-house-reared Tuebingen long-fin (TLF) zebrafish strain. Following UCS, inhibitory avoidance learning was assessed using a 3 day protocol where fish learn to avoid swimming from a white to a black compartment where they will receive a 3 V shock. Latencies of entering the black compartment were recorded before training (day 1; first shock) and after training on day 2 (second shock) and day 3 (no shock, tissue sampling). Fish whole-body cortisol content and expression levels of genes related to stress, fear and anxiety in the telencephalon were quantified. Following 14 days of UCS during the day, inhibitory avoidance learning decreased (lower latencies on days 2 and 3); minor effects were found following 7 days of UCS. Following 7 nights of UCS, inhibitory avoidance learning decreased (lower latency on day 3). Whole-body cortisol levels showed a steady increase compared with controls (100%) from 7 days of UCS (139%), to 14 days of UCS (174%) to 7 nights of UCS (231%), suggestive of an increasing stress load. Only in the 7 nights of UCS group did expression levels of corticoid receptor genes (mr, grα, grβ) and of bdnf increase. These changes are discussed as adaptive mechanisms to maintain neuronal integrity and prevent overload, and as being indicative of a state of high stress load. Overall, our data suggest that stressors during the resting phase have a stronger impact than during the active phase. Our data warrant further studies on the effect of UCS on stress axis-related genes, especially grβ; in mammals this receptor has been implicated in glucocorticoid resistance and depression.

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“…CART receptor or interaction partner has not been reported [102,103]. Using molecular genetics approaches we identified the first interaction protein for CART it is the mitochondrial protein SDH subunit B [11].…”

Section: Cart Has a Neurotrophic Role Via Mitochondria And Antioxidanmentioning

confidence: 99%

“…CART also increases SDH and mitochondrial complex II activities and ATP generation in both basal and ischemic conditions [11], suggesting the new mitochondrial mechanisms of CART's neurotrophic or neuroprotective role. Interestingly, in vivo study has shown that intracerebroventricularly injection of CART increases spatial learning and memory in rats subjected to the acquisition protocol in Morris water maze [103]. On the other hand, endogenous CART was upregulated in the frontal cortex, hypothalamus, amygdala, medulla oblongata and adrenal gland after the forced swim stress [104].…”

Section: Cart Has a Neurotrophic Role Via Mitochondria And Antioxidanmentioning

confidence: 99%

Recent progress and concerns in dementia: Distinguishing Alzheimer's disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid

Mao¹

2012

ABC

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Dementia is mainly a neurodegenerative disorder involved in several systems, including central nervous system, endocrinology/metabolism system and circulatory system. Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the most common forms of the dementia, accounting for 60% -80% and 10% -20% of all cases, respectively. DLB is defined by widespread neocortical, limbic and brainstem Lewy bodies but frequently accompanied by variable levels of AD pathology. This pathological and clinical overlap makes their differential diagnosis complicated. Recent advances in the identification of disease biomarkers now make it possible to detect and distinguish their pathology in the early or preclinical stage of the diseases, even in cognitively normal individuals. In addition to the key biomarkers (amyloid β or Aβ, tau and α-synuclein), neurotrophins such as cocaineand amphetamine-regulated transcript (CART) have also drawn attention due to their expressions and functions. This article summarizes the progress in the definition, pathology and diagnosis of dementia, with a focus on potential biochemical markers in the cerebrospinal fluid (CSF) in the differential diagnosis of the main forms of dementia. To prediction or early diagnosis of dementia, the role of specific and sensitive CSF biomarkers seems to be crucial in a routine clinical setting. The concerns and challenges in the biomarker field are also discussed.

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Cocaine- and amphetamine-regulated transcript peptide increases spatial learning and memory in rats

Cited by 47 publications

References 66 publications

Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex

Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Recent progress and concerns in dementia: Distinguishing Alzheimer's disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid

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