Cocaine Enhances Monocyte Migration Across the Blood-Brain Barrier

Fiala, Milan; Gan, Xiaohu; Zhang, L.; House, Steven; Newton, Thomas F.; Graves, Michael C.; Shapshak, Paul; Stins, Monique F.; Kim, K.-S.; Witte, Marlys H.; Chang, Sulie L.

doi:10.1007/978-1-4615-5347-2_22

Cited by 109 publications

(66 citation statements)

References 9 publications

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“…Cocaine has also been shown to cause endothelial dysfunction through its direct effect on microvascular endothelial cells and through indirect effects via the release of proinflammatory cytokines (21,(67)(68)(69). In the present study, we demonstrated down-modulation in the expression of TJPs in pECs on exposure to Tat and/or cocaine.…”

Section: Discussionsupporting

confidence: 62%

Effect of Cocaine on Human Immunodeficiency Virus–Mediated Pulmonary Endothelial and Smooth Muscle Dysfunction

Dhillon

Xue

et al. 2011

Am J Respir Cell Mol Biol

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Section: Discussionsupporting

confidence: 62%

Effect of Cocaine on Human Immunodeficiency Virus–Mediated Pulmonary Endothelial and Smooth Muscle Dysfunction

Dhillon

Xue

et al. 2011

Am J Respir Cell Mol Biol

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“…85,89 Indeed, cocaine exhibits cell-specific and concentration sensitive multimodal interactions with endothelial, immune, and neuroendocrine cells that strongly converge on BBB dysfunction and increased brain extravasation of reactive molecules and immune cells. 91,92 It should also be noted that intense hyperthermia associated with cocaine administration can also evoke potential BBB damage and brain edema. 89 Assessment of the complex pathophysiological effects of cocaine on BBB integrity revealed a spectrum of molecular pathways linked to endothelial dysfunction, as depicted by the schematic in Figure 3.…”

Section: Cocaine Abuse and Blood-brain Barrier Impairmentmentioning

confidence: 99%

“…95 A major consequence of cocaine-induced BBB inflammatory response and loss of barrier integrity is an increased infiltration of circulating immune cells. 91,93,94,96 It is well established that cocaine potentiates endothelial-monocyte interactions through dosedependent up-regulation of inflammatory mediators and cell adhesion molecules (such as ICAM-1, VCAM, and ALCAM) at the BBB endothelium. 86,91,96 Interestingly, cocaine-induced ALCAM expression involves the activation of s1 receptor-PDGF-b signaling axis.…”

Section: Cocaine Abuse and Blood-brain Barrier Impairmentmentioning

confidence: 99%

“…91,93,94,96 It is well established that cocaine potentiates endothelial-monocyte interactions through dosedependent up-regulation of inflammatory mediators and cell adhesion molecules (such as ICAM-1, VCAM, and ALCAM) at the BBB endothelium. 86,91,96 Interestingly, cocaine-induced ALCAM expression involves the activation of s1 receptor-PDGF-b signaling axis. 96 In addition, increased transcription of inflammatory signaling molecules by NF-kB activation and nuclear translocation could mediate cocaine-induced endothelial activation and monocyte transmigration across BBB.…”

Section: Cocaine Abuse and Blood-brain Barrier Impairmentmentioning

confidence: 99%

See 1 more Smart Citation

Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress

Sajja

Rahman

Cucullo

2015

J Cereb Blood Flow Metab

119

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Psychostimulants and nicotine are the most widely abused drugs with a detrimental impact on public health globally. While the long-term neurobehavioral deficits and synaptic perturbations are well documented with chronic use of methamphetamine, cocaine, and nicotine, emerging human and experimental studies also suggest an increasing incidence of neurovascular complications associated with drug abuse. Short-or long-term administration of psychostimulants or nicotine is known to disrupt blood-brain barrier (BBB) integrity/function, thus leading to an increased risk of brain edema and neuroinflammation. Various pathophysiological mechanisms have been proposed to underlie drug abuse-induced BBB dysfunction suggesting a central and unifying role for oxidative stress in BBB endothelium and perivascular cells. This review discusses drug-specific effects of methamphetamine, cocaine, and tobacco smoking on brain microvascular crisis and provides critical assessment of oxidative stress-dependent molecular pathways focal to the global compromise of BBB. Additionally, given the increased risk of human immunodeficiency virus (HIV) encephalitis in drug abusers, we have summarized the synergistic pathological impact of psychostimulants and HIV infection on BBB integrity with an emphasis on unifying role of endothelial oxidative stress. This mechanistic framework would guide further investigations on specific molecular pathways to accelerate therapeutic approaches for the prevention of neurovascular deficits by drugs of abuse.

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“…Cocaine may have a direct effect on the endothelium as well as pro-inflammatory effects when it accelerates HIV-associated dementia [123,124]. Nicotine, a major component in tobacco products, alters the transportation of glucose and ions at the BBB and decreases the expression of ZO-1, which increases BBB permeability [125].…”

Section: Diseases and Other Factors Affecting The Bbbmentioning

confidence: 99%