Coccidioidomycosis prostatitis associated with prostate cancer

Coccidioidomycosis of the prostate: a determination of incidence, report of 4 cases, and treatment recommendations

“…Previously, only case report data has been published. [8][9][10][11][12][13][14][15][16][17] Our study confirms the rarity of this diagnosis as we found an incidence of the disease in 0.1% of men coming to our hospitals for prostate biopsies of suspected carcinoma or treatment of disorders requiring removal of prostate tissue (i.e. BPH, carcinoma).…”

“…7 To date, eleven confirmed clinical cases of prostate coccidioidomycosis have been reported in the literature (Table 1). [8][9][10][11][12][13][14][15][16][17] Nine cases were diagnosed antemortem and two cases were diagnosed postmortem. Definitive diagnoses were made by histopathologic examination of prostate tissue.…”

How to diagnose and treat fungal infections in chronic prostatitis

“…Risk factors include steroid use, chemotherapy, malignancy, and seropositive for HIV [41,42]. Coccidioides immitis granulomas have been found in the prostate, seminal vesicles, and lymph nodes of patients who underwent radical prostatectomy and bilateral pelvic lymphadenectomy for adenocarcinoma [43,44]. In one patient, coccidioides infection was the cause of prostate adherence to surrounding tissue and palpable lymphadenopathy [44].…”

“…Coccidioides immitis granulomas have been found in the prostate, seminal vesicles, and lymph nodes of patients who underwent radical prostatectomy and bilateral pelvic lymphadenectomy for adenocarcinoma [43,44]. In one patient, coccidioides infection was the cause of prostate adherence to surrounding tissue and palpable lymphadenopathy [44]. Prostatic infection generally is a manifestation of multifocal or systemic disease; hence, systemic therapy with intravenous amphotericin B or the imidazoles, or both, is advocated [45].…”

How to diagnose and treat fungal infections in chronic prostatitis

“…Following inhalation of the arthroconidia, an asymptomatic and transient pulmonary infection may develop. Coccidioides immitis granulomas have been found in the prostate, seminal vesicles, and lymph nodes of patients who underwent radical prostatectomy and bilateral pelvic lymphadenectomy for adenocarcinoma [43,44]. Most patients may develop a low-grade respiratory infection; it has been estimated that less than 1% of patients have extra-pulmonary manifestations that include the meninges, bone, joints, skin, and soft tissue.…”