Coconut Water and Milk Modulate Intravascular Haemolysis and Hepatotoxicity Via Oxido-Inflammatory Mechanism in Rats

Abstract

Phenylhydrazine (C6H5NHNH2; PHZ) is a redox derivative of hydrazine with wide applicability in chemical-based industries. Exposure to PHZ can be established via oral, inhalation, and dermal routes 1 . Its use as a pharmacological agent against polycythaemia vera qualifies it as a toxicological agent of haemolysis in healthy animals. Beyond its hematological toxicities, PHZ forms several intermediates such as phenyldiazene and heme adducts such as N-alkylprotoporphyrin IX which act as free radicals ultimately damaging the liver through oxidative stress. Hence, PHZ has been used in several experimental conditions to induce both hematological and hepatological injuries in oxidative and inflammation-mediated pathophysiology. 2,3