Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

Mukherjee, Arijit; Rogers, Robin D.; Myerson, Allan S.

doi:10.1039/c8ce00859k

Cited by 46 publications

(42 citation statements)

References 31 publications

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“…Parameters for controlling polymorphism in LAG are many, and include liquid polarity, anion choice (in ionic liquids), and η . Theoretical work has begun to offer explanations for mechanochemical interconversion of polymorphs, relating it to changes in polymorph stabilities on particle size reduction .…”

Section: Flavors Of Mechanochemistrymentioning

confidence: 99%

Mechanochemistry for Synthesis

2019

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Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers not only a possibility to eliminate the need for bulk solvent use, and reduce the generation of waste, but it also unlocks the door to a different reaction environment in which synthetic strategies, reactions and molecules previously not accessible in solution, can be achieved. This Minireview examines the potential of mechanochemistry in chemical and materials synthesis, by providing a cross‐section of the recent developments in using ball milling for the formation of molecules and materials based on covalent and coordination bonds.

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Section: Flavors Of Mechanochemistrymentioning

confidence: 99%

Mechanochemistry for Synthesis

2019

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“…[13] The last decade has witnessed an immense interest in translating reactions from solution to the solid state, which propelled mechanochemistry among the most promising fields of chemical science with "the potential to change the world", as recognized by the International Union for Pure and Applied Chemistry (IUPAC) in 2019. [14] Following the discoveries of controlling the solid-state reactivity by adding liquid or solid additives, such as liquid-(LAG) [15] or ion-and liquid-assisted grinding (ILAG), [16] polymer-assisted grinding (POLAG), [17] or ionic-liquid-assisted grinding (IL-AG), [18] the introduction of new methodologies such as liquid-assisted resonant acoustic mixing (LA-RAM) [19] or mechanochemically-assisted solid-state photocatalysis (MASSPC), [20] or by measuring the temperature effects during ball milling, [21] mechanochemistry has emerged as a means of doing chemical reactions in a safe, efficient, and green manner. [22] Development of advanced in situ monitoring techniques, [23] alongside ex situ measurements, [24] has greatly contributed to understanding of mechanochemical reactions on a microscopic level.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Solid‐State Hydrolysis of Waste Polyethylene Terephthalate by Mechanochemical Milling and Vapor‐Assisted Aging

Štrukil

2020

ChemSusChem

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Despite significant methodological and technological advancements in chemical recycling of synthetic polymers, an efficient and quantitative conversion of post-consumer polyethylene terephthalate (PET) into terephthalic acid (TPA) under ambient conditions of temperature and pressure still remains a challenge. In this respect, the application of mechanochemistry and multiple advantages offered by solid-state ball milling and vapor-assisted aging have remained insufficiently explored. To further expand their potential, the implementation of organic solvent-free milling as a superior methodology for successful alkaline depolymerization of waste PET (e. g., bottles and textile) into TPA monomer in near-quantitative yields was reported herein. The solid-state alkaline PET hydrolysis was also shown to proceed in excellent yields under aging conditions in humid environment or in the presence of alcohol vapors. Moreover, the performance of mechanochemical ball milling and aging in the gram-scale depolymerization of PET into TPA was demonstrated.

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“…Due to the complexity of solvent-based techniques, solid-state synthesis of pharmaceutical co-crystals is often preferred as it is more efficient to modify the physicochemical properties (such as melting point, solubility, compressibility, stability) of the API ( 82 – 85 ). Solid-state techniques include grinding methods such as neat grinding in mills, liquid assisted, or polymer assisted grinding ( 86 – 88 ). The grinding methods eliminate the need for the knowledge of the solubility of the co-crystal materials.…”

Section: Recent Innovation Formulations Via Hot-mementioning

confidence: 99%

Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing

Tan

Davis

Miller³

et al. 2020

AAPS PharmSciTech

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Thermal processing has gained much interest in the pharmaceutical industry, particularly for the enhancement of solubility, bioavailability, and dissolution of active pharmaceutical ingredients (APIs) with poor aqueous solubility. Formulation scientists have developed various techniques which may include physical and chemical modifications to achieve solubility enhancement. One of the most commonly used methods for solubility enhancement is through the use of amorphous solid dispersions (ASDs). Examples of commercialized ASDs include Kaletra®, Kalydeco®, and Onmel®. Various technologies produce ASDs; some of the approaches, such as spray-drying, solvent evaporation, and lyophilization, involve the use of solvents, whereas thermal approaches often do not require solvents. Processes that do not require solvents are usually preferred, as some solvents may induce toxicity due to residual solvents and are often considered to be damaging to the environment. The purpose of this review is to provide an update on recent innovations reported for using hot-melt extrusion and KinetiSol® Dispersing technologies to formulate poorly water-soluble APIs in amorphous solid dispersions. We will address development challenges for poorly water-soluble APIs and how these two processes meet these challenges.

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Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

Abstract: Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs.

Cited by 46 publications

References 31 publications

Mechanochemistry for Synthesis

Mechanochemistry for Synthesis

Highly Efficient Solid‐State Hydrolysis of Waste Polyethylene Terephthalate by Mechanochemical Milling and Vapor‐Assisted Aging

Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing

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