Coding-Complete Genome Sequence of Yada Yada Virus, a Novel Alphavirus Detected in Australian Mosquitoes

Batovska, Jana; Buchmann, Jan P.; Holmes, Edward C.; Lynch, Stacey E.

doi:10.1128/mra.01476-19

Cited by 14 publications

(17 citation statements)

References 17 publications

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“…A striking insight into the importance of macrodomains comes from the recent emergence of a new, insect-specific group of alphaviruses, in addition to the known vertebrainfecting and aquatic alphaviruses. The host range of these viruses appears to be restricted to the former vectors, including mosquitos of the Aedes, Anopheles and Culex genera [91][92][93][94][95]. Sequence comparison of members of this group with closely related alphaviruses of the western equine encephalitis complex revealed specific loss of catalytically important residues within the macrodomain (figure 6; electronic supplementary material, figure S6).…”

Section: Phylogenetic Analysis Of the Ligand-binding Pocketmentioning

confidence: 99%

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

et al. 2020

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Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation. This brought them into focus as promising therapeutic targets, albeit the close homology to some of the human macrodomains raised concerns regarding potential cross-reactivity and adverse effects for the host. Here, we evaluate the structure and function of the macrodomain of SARS-CoV-2, the causative agent of COVID-19. We show that it can antagonize ADP-ribosylation by PARP14, a cellular (ADP-ribosyl)transferase necessary for the restriction of coronaviral infections. Furthermore, our structural studies together with ligand modelling revealed the structural basis for poly(ADP-ribose) binding and hydrolysis, an emerging new aspect of viral macrodomain biology. These new insights were used in an extensive evolutionary analysis aimed at evaluating the druggability of viral macrodomains not only from the Coronaviridae but also Togaviridae and Iridoviridae genera (causing diseases such as Chikungunya and infectious spleen and kidney necrosis virus disease, respectively). We found that they contain conserved features, distinct from their human counterparts, which may be exploited during drug design.

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Section: Phylogenetic Analysis Of the Ligand-binding Pocketmentioning

confidence: 99%

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

et al. 2020

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“…Unlike ISFVs, only a few insect-specific alphaviruses (ISAV) have been discovered so far: Eilat virus (EILV), Taï Forest alphavirus (TAFV), Mwinilunga virus (MWAV), Agua Salud virus (ASALV) and Yada Yada virus (YYV) [49][50][51][52][53]. TAFV was discovered in the Taï national park in the Ivory Coast in Culex decens mosquitoes [49].…”

Section: Insect-specific Virusesmentioning

confidence: 99%

“…ASALV and YYV are the most recently discovered ISAVs. ASALV was isolated from a pool of Culex mosquitoes in Central Panama, and YYV was isolated from Anopheles annulipes mosquitoes in Australia [51,53]. EILV, the first ISAV described, was isolated from a pool of Anopheles coustani mosquitoes collected near Jerusalem in 1984 [54].…”

Section: Insect-specific Virusesmentioning

confidence: 99%

Superinfection Exclusion in Mosquitoes and Its Potential as an Arbovirus Control Strategy

Lauréti

Paradkar

Fazakerley

et al. 2020

Viruses

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The continuing emergence of arbovirus disease outbreaks around the world, despite the use of vector control strategies, warrants the development of new strategies to reduce arbovirus transmission. Superinfection exclusion, a phenomenon whereby a primary virus infection prevents the replication of a second closely related virus, has potential to control arbovirus disease emergence and outbreaks. This phenomenon has been observed for many years in plants, insects and mammalian cells. In this review, we discuss the significance of identifying novel vector control strategies, summarize studies exploring arbovirus superinfection exclusion and consider the potential for this phenomenon to be the basis for novel arbovirus control strategies.

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“…We focus this Review on alphaviruses that are relevant to humans and other mammalian hosts. We note that there are other alphaviruses not covered in this Review, including ones that target fish that may have a large economic impact (32,33) and insect-specific alphaviruses (e.g., Eilat and Yada Yada viruses) (34,35).…”

Section: Introductionmentioning

confidence: 99%

Entry receptors — the gateway to alphavirus infection

Zimmerman¹,

Holmes²,

Kafai³

et al. 2023

Journal of Clinical Investigation

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Coding-Complete Genome Sequence of Yada Yada Virus, a Novel Alphavirus Detected in Australian Mosquitoes

Cited by 14 publications

References 17 publications

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

Superinfection Exclusion in Mosquitoes and Its Potential as an Arbovirus Control Strategy

Entry receptors — the gateway to alphavirus infection

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