Codonopsis lanceolata and Nelumbo nucifera Gaertn. root extracts for functional food: metabolic profiling by MS, FTIR and fluorescence and evaluation of cytotoxicity and anti-obesity properties on 3T3-L1 cell line

Boo, Hee-Ock; Kim, Hag-Hyun; Barasch, Dinorah; Nemirovski, Alina; Lee, Moon-Soon; Gorinstein, Shela; Ku, Yang Gyu

doi:10.1007/s00217-016-2782-1

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…It has been widely reported that the roots of these two species can be used for preventing diseases including inflammation, obesity, and cancer [3,4,5]. In addition, as a high-class vegetable, C. lanceolata has been consumed as food for several centuries, especially in ancient Korea [6,7]. Nowadays, new medicinal compounds continue to be reported from these two species, and their medicinal mechanisms have been demonstrating [3,8,9].…”

Section: Introductionmentioning

confidence: 99%

Night Temperature Affects the Growth, Metabolism, and Photosynthetic Gene Expression in Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

Ren

Jeong

2019

Plants

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Astragalus membranaceus and Codonopsis lanceolata are two important medical herbs used in traditional Oriental medicine for preventing cancer, obesity, and inflammation. Night temperature is an important factor that influences the plug seedling quality. However, little research has focused on how the night temperature affects the growth and development of plug seedlings of these two medicinal species. In this study, uniform plug seedlings were cultivated in three environmentally controlled chambers for four weeks under three sets of day/night temperatures (25/10 °C, 25/15 °C, or 25/20 °C), the same relative humidity (75%), photoperiod (12 h), and light intensity (150 μmol·m−2·s−1 PPFD) provided by white LEDs. The results showed that night temperature had a marked influence on the growth and development of both species. The night temperature of 15 °C notably enhanced the quality of plug seedlings evidenced by the increased shoot, root, and leaf dry weights, stem diameter, and Dickson’s quality index. Moreover, a night temperature of 15 °C also stimulated and increased contents of primary and secondary metabolites, including soluble sugar, starch, total phenols and flavonoids. Furthermore, the 15 °C night temperature increased the chlorophyll content and stomatal conductance and decreased the hydrogen peroxide content. Analysis of the gene expression showed that granule-bound starch synthase (GBSS), ribulose bisphosphate carboxylase large chain (RBCL), and ferredoxin (FDX) were up-regulated when the night temperature was 15 °C. Taken together, the results suggested that 15 °C is the optimal night temperature for the growth and development of plug seedlings of A. membranaceus and C. lanceolata.

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Section: Introductionmentioning

confidence: 99%

Night Temperature Affects the Growth, Metabolism, and Photosynthetic Gene Expression in Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

Ren

Jeong

2019

Plants

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“…Moreover, these agents have a wide range of pharmacological effects, such as strengthening the spleen, benefiting the lungs, nourishing the blood, and promoting the production of body fluids 3 , 5 , 7 , 8 . People in countries such as China, Japan, North Korea, South Korea, and the United States also use it as a food ingredient 9 , 10 . Owing to these health benefits, the demand for Codonopsis Radix has increased globally, stimulating the large-scale cultivation of C. pilosula , especially in Gansu Province 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Improvement in the quality and productivity of Codonopsis pilosula seedlings by dazomet soil fumigation

Wang,

Chen,

Guo

et al. 2024

Sci Rep

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Dazomet is a dry powder formulation that releases toxic gas containing methyl isothiocyanate, which controls soil-borne pests and weeds, improving crop yields when applied to moist soils. To explore the efficacy of dazomet fumigation in the cultivation of the perennial herb Codonopsis pilosula, four typical cultivars (G1, G2, W1 and TCK) in Gansu Province were selected for seedling cultivation after soil fumigation (F) by dazomet, and non-fumigated soil was used as a control (CK). The experiments took 2 years to complete. The functional diversity of the soil enzymes and microorganisms, seedling emergence and physiological characteristics, and the quality and yield of Codonopsis seedlings and Radix were assessed. The results showed that the seed emergence rate, seedling re-green rate and several antioxidant enzymatic activities improved in the treatments involving soil fumigation with dazomet, and membrane lipid peroxidation in the seedlings decreased. On average, compared with those of the respective controls, the root viability and yield of the seedlings of the tested cultivars also increased by 34.87% and 42.4%, respectively, and the incidence of root rot in the seedlings was reduced by 83.9%, compared with their respective controls. After harvest, the yield increased by 23.9%, the incidence of root rot decreased by 61.3%, increase in yield and a 61.3% reduction in incidence, and the medicinal materials were determined to be safe and residue-free. The effects of fumigation were cultivar-specific and were especially prominent in G2. Therefore, soil fumigation with dazomet could improve the quality and productivity of Codonopsis pilosula seedlings. Taken together, these findings suggest that when herbs are bred by seedling transplantation, especially cultivars of good quality but poor resistance or species with rare germplasm resources, soil fumigation provides a way to improve cultivation effectiveness and, more importantly, ensures the probability of successfully breeding the species.

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“…These two species have a long history of being used as medicine to treat many diseases including cancer, obesity, and inflammation in Asian countries [1,2]. In addition to having its medicinal values, C. lanceolata has been consumed as a high-class vegetable in Asian countries, especially in ancient Korea [3,4]. In recent years, more and more researchers have shown an increased interest in these two species, since more and more phytochemicals have been identified and applied in medicine for treating diseases [5,6].…”

Section: Introductionmentioning

confidence: 99%

Manipulating the Difference between the Day and Night Temperatures Can Enhance the Quality of Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

2019

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Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f. are two famous medical species in Korea, China, and Japan, mainly used for treating diseases including cancer, obesity, and inflammation. Manipulation of the difference between the day and night temperatures (DIF) is an efficient horticultural practice to regulate the growth and development of vegetables in a glasshouse. However, little research has focused on how the DIF influences the plug seedling quality of medicinal plants. In this study, uniform plug seedlings were cultivated in three environmentally controlled chambers under an average daily temperature of 20 °C with negative (−10 °C), zero, or positive (+10 °C) DIFs, and the same relative humidity (75%), photoperiod (12 h), and light intensity (150 μmol·m−2·s−1 photosynthetic photon flux density with white LEDs). The results showed that the DIF had a noticeable effect on the growth, development, and morphology of A. membranaceus and C. lanceolata plug seedlings. The positive DIF (+10 °C) significantly increased the biomass (shoot, root, and leaf), stem diameter, and Dickson’s quality index, indicating an enhanced plug seedling quality. Moreover, the contents of primary and secondary metabolites, including soluble sugar, starch, total phenols and flavonoids, were higher with higher DIFs, where the maximum values were found at 0 °C or +10 °C DIF. Furthermore, the increases in the chlorophyll content and stomatal conductance were obtained in a positive DIF, indicating that a positive DIF was favorable to photosynthesis. An analysis of the gene expression showed that a positive DIF (+10 °C) up-regulated the expression of photosynthetic genes, including GBSS, RBCL, and FDX. In conclusion, the results of this study recommend a positive DIF (+10 °C) for enhancing the quality of A. membranaceus and C. lanceolata plug seedlings.

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Codonopsis lanceolata and Nelumbo nucifera Gaertn. root extracts for functional food: metabolic profiling by MS, FTIR and fluorescence and evaluation of cytotoxicity and anti-obesity properties on 3T3-L1 cell line

Cited by 7 publications

References 35 publications

Night Temperature Affects the Growth, Metabolism, and Photosynthetic Gene Expression in Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

Night Temperature Affects the Growth, Metabolism, and Photosynthetic Gene Expression in Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

Improvement in the quality and productivity of Codonopsis pilosula seedlings by dazomet soil fumigation

Manipulating the Difference between the Day and Night Temperatures Can Enhance the Quality of Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

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