Coenzyme Q10 and Heart Failure

Sharma, Abhinav; Fonarow, Gregg C.; Butler, Javed; Ezekowitz, Justin A.; Felker, G. Michael

doi:10.1161/circheartfailure.115.002639

Cited by 123 publications

(73 citation statements)

References 58 publications

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“…In humans, CoQ 10 deficiency has been implicated in various diseases involving muscle and neural development, with the severity of the disease correlated with the acuteness of the CoQ 10 shortfall [18]. These diseases may manifest in conditions such as central nervous system (CNS) dysfunction, myopathy or cardiomyopathy, among others [19–22]. The oxidative damage associated with impaired CoQ 10 function has also been implicated in numerous clinical phenotypes [18, 23–25].…”

Section: Introductionmentioning

confidence: 99%

Cellular factories for coenzyme Q10 production

et al. 2017

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Coenzyme Q10 (CoQ10), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ10 is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ10, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ10 production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ10 production, and discuss some of the potential novel areas for future research.

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Section: Introductionmentioning

confidence: 99%

Cellular factories for coenzyme Q10 production

et al. 2017

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“…Ubiquinone Q10 plays a significant role in ATP production in mitochondria through the electron transport chain and possible reduction in oxidative stress. 35 …”

Section: Discussionmentioning

confidence: 99%

A Serum Small Molecule Biosignature of Radiation Exposure from Total Body Irradiated Patients

Laiakis¹,

Pannkuk²,

Chauthe³

et al. 2017

J. Proteome Res.

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The potential for radiological accidents and nuclear terrorism has increased the need for the development of new rapid biodosimetry methods. In addition, in a clinical setting the issue of an individual’s radiosensitivity should be taken into consideration during radiotherapy. We utilized metabolomics and lipidomics to investigate changes of metabolites in serum samples following exposure to total body ionizing radiation in humans. Serum was collected prior to irradiation, at 3–8 h after a single dose of 1.25–2 Gy, and at 24 h with a total delivered dose of 2–3.75 Gy. Metabolomics revealed perturbations in glycerophosphocholine, phenylalanine, ubiquinone Q2, and oxalic acid. Alterations were observed in circulating levels of lipids from monoacylglycerol, triacylglycerol, phosphatidylcholine, and phosphatidylglycerol lipid classes. Polyunsaturated fatty acids were some of the most dysregulated lipids, with increased levels linked to proinflammatory processes. A targeted metabolomics approach for eicosanoids was also employed. The results showed a rapid response for proinflammatory eicosanoids, with a dampening of the signal at the later time point. Sex differences were observed in the markers from the untargeted approach but not the targeted method. The ability to identify and quantify small molecules in blood can therefore be utilized to monitor radiation exposure in human populations.

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“…When considering drug interactions, since CoQ10 has some structural similarity to vitamin K, it may increase the metabolism of warfarin through selective interaction with cytochrome P450 enzymes (A. Sharma, Fonarow, Butler, Ezekowitz, & Felker, 2016). As a consequence, CoQ10 may reduce the response to warfarin, causing difficulties in achieving adequate anticoagulation in patients taking CoQ10 and warfarin.…”

Section: Safety and Precautionsmentioning

confidence: 99%

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Arenas-Jal

Suñé-Negre

García-Montoya

2020

Comp Rev Food Sci Food Safe

142

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World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050. Although noncommunicable diseases such as cardiovascular and neurodegenerative diseases, cancer, and diabetes are among the top 10 global causes of death, they can be prevented by risk factor reduction, early detection, and adequate treatment. Since a healthy diet along with dietary supplementation could play an important role to reduce morbidity and cut off its associated health care costs, research in the food and nutrition area is required to find solutions to global challenges affecting health. As a result of the healthy living trend, dietary supplements category is growing fast, leading to an urgent need for dietitians, physicians, and policy makers to broaden the scientific evidence on the efficacy and safety of a wide range of active ingredients. Coenzyme Q10 (CoQ10), as the third most consumed dietary supplement, and as a potential candidate for the treatment of various noncommunicable diseases that are among the global top 10 causes of death, has gained interest over years. Scientific evidence regarding mainly CoQ10 efficacy and safety, as well as formulation challenges, is addressed in this review.

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Coenzyme Q10 and Heart Failure

Cited by 123 publications

References 58 publications

Cellular factories for coenzyme Q10 production

Cellular factories for coenzyme Q10 production

A Serum Small Molecule Biosignature of Radiation Exposure from Total Body Irradiated Patients

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

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