Coexisting systemic lupus erythematosus and ankylosing spondylitis: a case report and review of the literature

Mh, Kook; Hg, Yoo; Mj, Hong; Wh, Yoo

doi:10.1177/0961203311428461

Cited by 9 publications

(11 citation statements)

References 7 publications

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“…These two autoimmune rheumatologic diseases, which have a different aetiopathogenesis as well as diverse clinical and genetic characteristics, are rarely seen together. To the best of our knowledge, there are only 8 reported cases of the coexistence of SLE and AS in the English literature (3)(4)(5)(6)(7)(8)(9)(10). Here, we report another case with the coexistence of these two diseases.…”

Section: Introductionmentioning

confidence: 77%

Coexistence of systemic lupus erythematosus and ankylosing spondylitis: another case report and review of the literature

Tarhan¹,

Argın²,

Can³

et al. 2014

Eur J Rheum

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The coexistence of systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) is very rare, and, to the best of our knowledge, there are only 8 reported cases in the English literature. Here, we present another case with the coexistence of these two diseases, and review the clinical and laboratory features of the previously reported cases. A 55 year-old female patient, with a diagnosis of SLE with locomotor, skin, renal and hematopoietic system involvement, which had been confirmed by relevant autoantibody positivity, and hypocomplementemia and biopsyproven membranous lupus nephritis, was referred to our clinic suffered from typical inflammatory low-back pain after eight years of follow-up. Sacroiliac magnetic resonance imaging (MRI) confirmed the presence of bilateral active sacroiliitis with bone marrow oedema. HLA-B27 was positive and bilateral calcaneal spurs were also detected by conventional radiography. Therefore, the additional diagnosis of AS was made, eight years after the diagnosis of SLE. Inflammatory low-back pain typically responded to treatment with non-steroidal anti-inflammatory drugs. Including the present case, most of the reported cases of the coexistence of SLE and AS are female, and SLE generally precedes the occurrence of AS. The present case is also notable as the patient had both MRI confirmation of bilateral active sacroiliitis and HLA-B27 positivity. The coexistence of these two diseases with different genetic backgrounds in the same patient is much lower than expected based upon their prevalence in the general population. Although it has been suggested that the very rare combination of the susceptibility genes of each disease may explain the rarity of coexistence, epidemiological data concerning the genetic risks for the coexistence of SLE and AS are not available.

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Section: Introductionmentioning

confidence: 77%

Coexistence of systemic lupus erythematosus and ankylosing spondylitis: another case report and review of the literature

Tarhan¹,

Argın²,

Can³

et al. 2014

Eur J Rheum

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“…Previously, 10 adult patients with SLE and SpA have been reported (Table 1). [5][6][7][8][9][10][11][12][13] Among them, eight patients (80%) had malar rash, seven (70%) had hematologic involvement, four (40%) had renal involvement and three (30%) had discoid rash revealing SLE. [5][6][7][8][9][10][11][12][13] All patients fulfilled the American Collage of Disease criteria for SLE.…”

Section: Discussionmentioning

confidence: 99%

“…Up to date, only 10 adult patients with SLE and SpA have been described (Table 1). [5][6][7][8][9][10][11][12][13]…”

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confidence: 99%

Coexistence of Juvenile Systemic Lupus Erythematosus and Juvenile Spondyloarthropathy: A Case Report and Review of the Literature

et al. 2020

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Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organ systems. Musculoskeletal (MS) involvement occurs in either during the disease course in 70-95% of SLE patients or as an initial finding in nearly 50% of the cases. 1,2 MS involvement may vary from myalgia, arthralgia, non-erosive arthritis, myositis, tenosynovitis to contractures and avascular necrosis. 2 However, coexistence of sacroiliitis 3,4 or spondyloarthropathy (SpA) is really scarce. 5 In this article, we reported a patient presenting with juvenile SLE and SpA and discussed the clinical and laboratory findings by the literature review. To the best of our knowledge, this is the first pediatric case with coexistence of juvenile SLE and SpA. CASE REPORT A 16-year-old Syrian female patient was admitted to our hospital with low-back pain present for two months. She was born by vaginal delivery at 39 weeks as the second child of consanguineous parents (first cousins). She had initially presented to a local medical center with fever, rash, fatigue, oral ulcers and pancytopenia a year before. She was diagnosed with SLE. Prednisolone (1 mg/kg) and hydroxychloroquine therapy was administered. One year later, she was referred to our hospital due to complaints of low-back pain worsening in the morning and after a long resting period during the last two months. She also suffered from morning stiffness lasting two-three hours and heel pain. On physical

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“…4 So far, only 9 cases of coexistence of SLE and AS have been reported. [5][6][7][8][9][10][11][12][13] In this report, we describe another case of such coexistence.…”

Section: Co-existence Of Systemic Lupus Erythematosus and Ankylosing mentioning

confidence: 99%

“…5,8 However, in 5 reported cases, symptoms of AS preceded those of SLE by several years, duration ranging from 4 years to 17 years. 7,9,10,12,13 Figure 3: T1WI hypo (3a), T2WI and STIR (3b) hyper intense signal changes are seen within subchondral marrow of both (more on left) sacroiliac joints with destruction of overlying articular cartilage resulting reduction of joint spaces ough sacroilitis may be a rare manifestation of SLE, its presence along with in ammatory back pain may be suggestive of an additional diagnosis. In a report by Nassonova et al, it was shown that 22 out of 43 male patients with SLE had radiological sacroilitis and 7 had ankylosis of sacroiliac joint.…”

Section: Case Summarymentioning

confidence: 99%

Co-existence of Systemic Lupus Erythematosus and Ankylosing Spondylitis - A Case Report

et al. 2019

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Co-existence of systemic lupus erythematosus and ankylosing spondylitis is not common. In this report, we present a 24-year-old woman with both the entities diagnosed in the course of time. Initially she presented with malar rash, photosensitivity, oral ulcer and polyarthritis. Her ANA and anti-Smith antibody were positive, but ant-ds DNA was negative. With these features, she was diagnosed as a case of systemic lupus erythematosus. Few months later, she was diagnosed with ankylosing spondylitis on the basis of inflammatory back pain and bilateral sacroilitis. Bangladesh Med J. 2017 Sep; 46 (3): 100-103

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Coexisting systemic lupus erythematosus and ankylosing spondylitis: a case report and review of the literature

Cited by 9 publications

References 7 publications

Coexistence of systemic lupus erythematosus and ankylosing spondylitis: another case report and review of the literature

Coexistence of systemic lupus erythematosus and ankylosing spondylitis: another case report and review of the literature

Coexistence of Juvenile Systemic Lupus Erythematosus and Juvenile Spondyloarthropathy: A Case Report and Review of the Literature

Co-existence of Systemic Lupus Erythematosus and Ankylosing Spondylitis - A Case Report

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